Entity Details

Primary name C5AR2_HUMAN
Entity type UniProt
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Details

AccessionQ9P296
EntryNameC5AR2_HUMAN
FullNameC5a anaphylatoxin chemotactic receptor 2
TaxID9606
Evidenceevidence at protein level
Length337
SequenceStatuscomplete
DateCreated2002-03-05
DateModified2021-06-02

Ontological Relatives

GenesC5AR2

GO terms

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GOName
GO:0002430 complement receptor mediated signaling pathway
GO:0004875 complement receptor activity
GO:0004878 complement component C5a receptor activity
GO:0004930 G protein-coupled receptor activity
GO:0005886 plasma membrane
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0009925 basal plasma membrane
GO:0016021 integral component of membrane
GO:0030449 regulation of complement activation
GO:0032677 regulation of interleukin-8 production
GO:0032715 negative regulation of interleukin-6 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0045177 apical part of cell
GO:0050679 positive regulation of epithelial cell proliferation
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0090024 negative regulation of neutrophil chemotaxis

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR000826 Formyl peptide receptor-relatedFamilyFamily
IPR001274 C5a1/C5a2 anaphylatoxin chemotactic receptorFamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain
IPR027809 C5a anaphylatoxin chemotactic receptor 2FamilyFamily

Diseases

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