Entity Details

Primary name TBK1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UHD2
EntryNameTBK1_HUMAN
FullNameSerine/threonine-protein kinase TBK1
TaxID9606
Evidenceevidence at protein level
Length729
SequenceStatuscomplete
DateCreated2005-12-20
DateModified2021-06-02

Ontological Relatives

GenesTBK1

GO terms

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GOName
GO:0002218 activation of innate immune response
GO:0003676 nucleic acid binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006468 protein phosphorylation
GO:0006954 inflammatory response
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0009615 response to virus
GO:0016032 viral process
GO:0016239 positive regulation of macroautophagy
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0019903 protein phosphatase binding
GO:0032479 regulation of type I interferon production
GO:0032480 negative regulation of type I interferon production
GO:0032481 positive regulation of type I interferon production
GO:0032727 positive regulation of interferon-alpha production
GO:0032728 positive regulation of interferon-beta production
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0042802 identical protein binding
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043231 intracellular membrane-bounded organelle
GO:0044565 dendritic cell proliferation
GO:0045087 innate immune response
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0050830 defense response to Gram-positive bacterium
GO:0051219 phosphoprotein binding
GO:0051607 defense response to virus
GO:0060340 positive regulation of type I interferon-mediated signaling pathway
GO:0071345 cellular response to cytokine stimulus
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1901214 regulation of neuron death
GO:1904417 positive regulation of xenophagy

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR041087 TANK binding kinase 1, ubiquitin-like domainDomainDomain
IPR041309 TANK-binding kinase 1, coiled-coil domain 1DomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule

Interactions

168 interactions

InteractorPartnerSourcesPublicationsLink
TBK1_HUMANTANK_HUMANBioGRID, HPRD, IntAct, MINT, UniProt10581243 14743216 17568778 17823124 18307994 21903422 21931555 21988832 23007157 23286385 24488098 25409927 27035970 29251827 29395067 30420664 30561431 31114588 details
TBK1_HUMANTBK1_HUMANBioGRID, HPRD, IntAct, MINT14560022 14743216 17599067 19656901 23286385 23453972 25939384 26915459 28871090 31534043 details
TBK1_HUMANNEMO_HUMANBioGRID, HPRD, IntAct14743216 20098747 21903422 23028469 26611359 28514442 30561431 details
TBK1_HUMANTBKB1_HUMANBioGRID, IntAct, MINT, UniProt14743216 17568778 21903422 21931555 23286385 27035970 29395067 30420664 details
TBK1_HUMANTRAF2_HUMANBioGRID, HPRD, IntAct10990461 14743216 20449947 20562859 21903422 23007157 27135603 28514442 29125880 30420664 30561431 32041822 details
TBK1_HUMANIRF3_HUMANBioGRID, HPRD, IntAct, MINT, UniProt12692549 15695821 15841462 16394098 17599067 18583960 18636086 19153231 19656901 20628368 21903422 22072751 22079989 22388039 23028469 24807708 25636800 25803835 28346439 30267576 31534043 32241891 details
TBK1_HUMANTRAF3_HUMANBioGRID, HPRD, IntAct17991829 20174559 22079989 22330071 22792062 22908223 23308279 23717208 23986588 24622840 24763515 26928339 27135603 28049150 29125880 29920243 31404116 32324863 32779804 33372174 33411856 details
TBK1_HUMANIKKE_HUMANBioGRID, IntAct, MINT17599067 21903422 25939384 29251827 30420664 31534043 32298923 details
TBK1_HUMANOPTN_HUMANBioGRID, IntAct, MINT18307994 20174559 21903422 23414517 25803835 25923723 26365381 27035970 27086836 27538435 27620379 29395067 30327196 31723608 32556086 details
TBK1_HUMANSTX11_HUMANBioGRID, IntAct21988832 28514442 details
TBK1_HUMANCACO2_HUMANBioGRID, IntAct19820708 21903422 28514442 30309841 details
TBK1_HUMANTRAF6_HUMANBioGRID28049150 29125880 30530224 details
TBK1_HUMANAZI2_HUMANBioGRID, HPRD, IntAct, UniProt14560022 14743216 17568778 21903422 21931555 23286385 27620379 29251827 29395067 30420664 details
TBK1_HUMANMIB2_HUMANBioGRID, IntAct21903422 details
TBK1_HUMANSQSTM_HUMANBioGRID25972374 27035970 32835772 details
TBK1_HUMANXIAP_HUMANBioGRID, IntAct16887178 22072751 details
TBK1_HUMANCYLD_HUMANBioGRID, MINT18636086 25923723 29755980 details
TBK1_HUMANATG9A_HUMANBioGRID, IntAct21903422 details
TBK1_HUMANPTPRD_HUMANBioGRID, MINT22305495 details
TBK1_HUMANIKBA_HUMANBioGRID, HPRD10783893 20449947 8601309 9721103 details
TBK1_HUMANAKT1_HUMANBioGRID21106850 28716898 details
TBK1_HUMANPBIP1_HUMANBioGRID24488098 details
TBK1_HUMANMAVS_HUMANBioGRID, HPRD, IntAct, UniProt16153868 21813773 21903422 23028469 24643253 25636800 28346439 29125880 29743353 32366851 32511263 33372174 details
TBK1_HUMANAGO2_HUMANBioGRID, IntAct21903422 details
TBK1_HUMANMRCKG_HUMANBioGRID, IntAct21903422 details
TBK1_HUMANPROS_HUMANBioGRID, IntAct21988832 details
TBK1_HUMANSTAT6_HUMANIntAct22000020 details
TBK1_HUMANTXLNA_HUMANBioGRID, IntAct21903422 28514442 29395067 details
TBK1_HUMANMIB1_HUMANBioGRID, IntAct21903422 31462741 details
TBK1_HUMANPAPD1_HUMANBioGRID, IntAct21903422 details
TBK1_HUMANPELI1_HUMANBioGRID21204785 26082489 details
TBK1_HUMANRN128_HUMANBioGRID27776110 details
TBK1_HUMANTRI23_HUMANBioGRID28871090 31189704 details
TBK1_HUMANNCK1_HUMANBioGRID, HPRD7706279 details
TBK1_HUMANDDX3X_HUMANMINT18583960 details
TBK1_HUMANTF65_HUMANBioGRID, HPRD14560022 14743216 15489227 details
TBK1_HUMANTRI27_HUMANBioGRID16393995 29688809 details
TBK1_HUMANIRF7_HUMANBioGRID, MINT17599067 details
TBK1_HUMANA4_HUMANBioGRID21832049 details
TBK1_HUMANCIKS_HUMANBioGRID22851696 details
TBK1_HUMANRO52_HUMANBioGRID29667579 details
TBK1_HUMANNEDD4_HUMANBioGRID19953087 details
TBK1_HUMANSOCS3_HUMANBioGRID25939384 details
TBK1_HUMANSMCR8_HUMANBioGRID27103069 details
TBK1_HUMANMLP3B_HUMANBioGRID21617041 details
TBK1_HUMANRIPK1_HUMANBioGRID30420664 details
TBK1_HUMANCRTC1_HUMANBioGRID33411856 details
TBK1_HUMANMBP_HUMANBioGRID17599067 details
TBK1_HUMANKS6B1_HUMANBioGRID28716898 details
TBK1_HUMANTXLNG_HUMANBioGRID21903422 29395067 details
TBK1_HUMANSMUF1_HUMANBioGRID20804422 details
TBK1_HUMANTRAF5_HUMANBioGRID29125880 details
TBK1_HUMANBIP_HUMANIntAct14743216 details
TBK1_HUMANATPA_HUMANIntAct14743216 details
TBK1_HUMANRLA0L_HUMANIntAct14743216 details
TBK1_HUMANTCAM1_HUMANBioGRID, DIP, HPRD, IntAct, UniProt14530355 15841462 19416887 19656901 21903422 25736436 28049150 28747347 31511519 details
TBK1_HUMANSTING_HUMANBioGRID, DIP, HPIDb, IntAct18724357 19416887 19433799 21074459 21903422 22745133 23542348 24622840 28346439 28763789 29899553 30943264 31534043 32383759 33086059 33139700 details
TBK1_HUMANICOS_HUMANBioGRID, IntAct27135603 details
TBK1_HUMANTNR1A_HUMANBioGRID30420664 details
TBK1_HUMANPRP19_HUMANBioGRID29395067 details
TBK1_HUMANUBP15_HUMANBioGRID32814047 details
TBK1_HUMANRS18_HUMANIntAct14743216 details
TBK1_HUMANTCPH_HUMANIntAct14743216 details
TBK1_HUMANCALM2_HUMANIntAct14743216 details
TBK1_HUMANDTX4_HUMANBioGRID22388039 details
TBK1_HUMANWDR48_HUMANBioGRID29138248 details
TBK1_HUMANDCP1A_HUMANBioGRID29395067 details
TBK1_HUMANSIR2_HUMANBioGRID29395067 details
TBK1_HUMANPSMF1_HUMANBioGRID31114588 details
TBK1_HUMANHS90A_HUMANBioGRID, HPRD, IntAct14743216 16394098 20628368 22939624 details
TBK1_HUMANTNAP3_HUMANBioGRID, IntAct15661910 19615732 21885437 30561431 details
TBK1_HUMANTLR3_HUMANBioGRID21911421 27810922 details
TBK1_HUMANNCOA2_HUMANBioGRID16051665 details
TBK1_HUMANTAXB1_HUMANBioGRID21885437 28877469 31723608 details
TBK1_HUMANPATL1_HUMANBioGRID29395067 details
TBK1_HUMANSIKE1_HUMANHPRD16281057 details
TBK1_HUMANRL7_HUMANIntAct14743216 details
TBK1_HUMANRBCC1_HUMANBioGRID, IntAct20562859 30853401 details
TBK1_HUMANGSK3B_HUMANBioGRID26915459 details
TBK1_HUMANUBP1_HUMANBioGRID29138248 details
TBK1_HUMANZC12A_HUMANBioGRID29920243 details
TBK1_HUMANR144B_HUMANBioGRID31509299 details
TBK1_HUMANOBI1_HUMANBioGRID29395067 details
TBK1_HUMANCTBL1_HUMANBioGRID27035970 details
TBK1_HUMANYAP1_HUMANBioGRID28346439 details
TBK1_HUMANHSP7C_HUMANIntAct14743216 details
TBK1_HUMANGRP75_HUMANIntAct14743216 details
TBK1_HUMANUBC_HUMANMINT18636086 details
TBK1_HUMANUBB_HUMANIntAct24622840 details
TBK1_HUMANTCPQ_HUMANIntAct14743216 details
TBK1_HUMANTBA3D_HUMANIntAct14743216 details
TBK1_HUMANRL13_HUMANIntAct14743216 details
TBK1_HUMANTNFA_HUMANBioGRID15485837 27307491 27545878 30420664 details
TBK1_HUMANTRIM9_HUMANBioGRID26915459 details
TBK1_HUMANMTOR_HUMANBioGRID28716898 details
TBK1_HUMANRRAGD_HUMANBioGRID28716898 details
TBK1_HUMANRN214_HUMANBioGRID29395067 details
TBK1_HUMANTCPG_HUMANIntAct14743216 details
TBK1_HUMANWHRN_HUMANBioGRID, IntAct27173435 unassigned1312 details
TBK1_HUMANRIOK3_HUMANUniProt24807708 details
TBK1_HUMANTRAIP_HUMANBioGRID22945920 details
TBK1_HUMANUBP2_HUMANBioGRID25070846 details
TBK1_HUMANSMAG2_HUMANBioGRID29395067 details
TBK1_HUMANIRF5_HUMANHPRD15556946 15695821 details
TBK1_HUMANEXOC2_HUMANBioGRID24056301 28716898 details
TBK1_HUMANTNR6B_HUMANBioGRID29395067 details
TBK1_HUMANTTP_HUMANBioGRID29395067 details
TBK1_HUMANTBB5_HUMANIntAct14743216 details
TBK1_HUMANNALP4_HUMANBioGRID22388039 26407194 details
TBK1_HUMANDDX58_HUMANBioGRID23950712 details
TBK1_HUMANTRI14_HUMANBioGRID24379373 details
TBK1_HUMANRNF31_HUMANBioGRID30420664 details
TBK1_HUMANTSC2_HUMANBioGRID28716898 details
TBK1_HUMANCNTRL_HUMANBioGRID29395067 details
TBK1_HUMANDNJA1_HUMANBioGRID29395067 details
TBK1_HUMANDPCD_HUMANBioGRID29395067 details
TBK1_HUMANLG3BP_HUMANBioGRID, IntAct14743216 31404116 details
TBK1_HUMANTNIP1_HUMANBioGRID, IntAct21885437 30561431 details
TBK1_HUMANTLR9_HUMANBioGRID21911421 details
TBK1_HUMANTRI26_HUMANBioGRID26611359 details
TBK1_HUMANTNR6C_HUMANBioGRID29395067 details
TBK1_HUMANRUVB2_HUMANBioGRID, IntAct14743216 29395067 details
TBK1_HUMANIKKB_HUMANHPRD, IntAct14560022 21782231 details
TBK1_HUMANTLR4_HUMANBioGRID21911421 details
TBK1_HUMANRNF11_HUMANBioGRID23308279 details
TBK1_HUMANKSYK_HUMANBioGRID23962979 details
TBK1_HUMANHERP1_HUMANBioGRID28954889 details
TBK1_HUMANLZTS2_HUMANBioGRID29395067 details
TBK1_HUMANTNR6A_HUMANBioGRID29395067 details
TBK1_HUMANHS90B_HUMANHPRD, IntAct14743216 22939624 details
TBK1_HUMANRPTOR_HUMANBioGRID28716898 details
TBK1_HUMANEXOC7_HUMANBioGRID28716898 details
TBK1_HUMANGOGA3_HUMANBioGRID29395067 details
TBK1_HUMANNACC1_HUMANBioGRID31235549 details
TBK1_HUMAN1433E_HUMANBioGRID20462248 details
TBK1_HUMANSC16A_HUMANBioGRID31114588 details
TBK1_HUMANG3P_HUMANIntAct, MINT14743216 17599067 details
TBK1_HUMANRL11_HUMANIntAct14743216 details
TBK1_HUMANULK1_HUMANBioGRID28716898 details
TBK1_HUMANLEG3_HUMANBioGRID30404831 details
TBK1_HUMANUBE2S_HUMANBioGRID32814047 details
TBK1_HUMANDYRK2_HUMANBioGRID26407194 details
TBK1_HUMANCK5P2_HUMANBioGRID29395067 details
TBK1_HUMANTFG_HUMANBioGRID33411856 details
TBK1_HUMANRS5_HUMANIntAct14743216 details
TBK1_HUMANLDHB_HUMANIntAct14743216 details
TBK1_HUMANHNRPM_HUMANIntAct14743216 details
TBK1_HUMANTCPE_HUMANIntAct14743216 details
TBK1_HUMANTTC4_HUMANIntAct29251827 details
TBK1_HUMANSRC_HUMANBioGRID19419966 details
TBK1_HUMANTCPA_HUMANIntAct14743216 details
TBK1_HUMANTCPZ_HUMANIntAct14743216 details
TBK1_HUMANNONO_HUMANIntAct14743216 details
TBK1_HUMANTCPD_HUMANIntAct14743216 details
TBK1_HUMANM3K14_HUMANInnateDB23023393 details
TBK1_HUMANTOM70_HUMANBioGRID20628368 details
TBK1_HUMANMARF1_HUMANBioGRID29395067 details
TBK1_HUMANRUVB1_HUMANIntAct14743216 details
TBK1_HUMANDNJA2_HUMANBioGRID29395067 details
TBK1_HUMANIFIT3_HUMANBioGRID21813773 details
TBK1_HUMANESR1_HUMANBioGRID26186972 details
TBK1_HUMANPRKN_HUMANBioGRID29903906 details
TBK1_HUMANTBB4A_HUMANIntAct14743216 details
TBK1_HUMANTCPB_HUMANIntAct14743216 details
TBK1_HUMANRS8_HUMANIntAct14743216 details
TBK1_HUMANSFPQ_HUMANIntAct14743216 details
TBK1_HUMANTBA3C_HUMANIntAct14743216 details
TBK1_HUMANMEX3B_HUMANBioGRID29395067 details