Entity Details

Primary name AKA10_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO43572
EntryNameAKA10_HUMAN
FullNameA-kinase anchor protein 10, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length662
SequenceStatuscomplete
DateCreated2001-02-21
DateModified2021-06-02

Ontological Relatives

GenesAKAP10

GO terms

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GOName
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0007165 signal transduction
GO:0007596 blood coagulation
GO:0008104 protein localization
GO:0032991 protein-containing complex
GO:0051018 protein kinase A binding

Subcellular Location

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Subcellular Location
Cytoplasm
Membrane
Mitochondrion

Domains

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DomainNameCategoryType
IPR016137 RGS domainDomainDomain
IPR036305 RGS domain superfamilyFamilyHomologous superfamily
IPR037719 A-kinase anchor protein 10, PKA-binding (AKB) domainDomainDomain

Diseases

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Disease IDSourceNameDescription
115080 OMIMSudden cardiac death (SCD)Unexpected rapid death due to cardiovascular collapse in a short time period, generally within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as chest pain and cardiac arrhythmias, particularly ventricular tachycardia, can lead to the loss of consciousness and cardiac arrest followed by biological death. Disease susceptibility is associated with variants affecting the gene represented in this entry. Increased susceptibility to sudden cardiac death may be conferred by AKAP10 variants that are associated with markers of low vagus nerve sensitivity, e.g. fast basal heart rate and low heart rate variability.