Entity Details

Primary name GDF2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UK05
EntryNameGDF2_HUMAN
FullNameGrowth/differentiation factor 2
TaxID9606
Evidenceevidence at protein level
Length429
SequenceStatuscomplete
DateCreated2001-02-21
DateModified2021-06-02

Ontological Relatives

GenesGDF2

GO terms

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GOName
GO:0001503 ossification
GO:0001525 angiogenesis
GO:0001569 branching involved in blood vessel morphogenesis
GO:0001570 vasculogenesis
GO:0001649 osteoblast differentiation
GO:0001937 negative regulation of endothelial cell proliferation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0005125 cytokine activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0006879 cellular iron ion homeostasis
GO:0008083 growth factor activity
GO:0008156 negative regulation of DNA replication
GO:0010596 negative regulation of endothelial cell migration
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0016525 negative regulation of angiogenesis
GO:0030308 negative regulation of cell growth
GO:0030509 BMP signaling pathway
GO:0030513 positive regulation of BMP signaling pathway
GO:0032757 positive regulation of interleukin-8 production
GO:0032924 activin receptor signaling pathway
GO:0043537 negative regulation of blood vessel endothelial cell migration
GO:0045603 positive regulation of endothelial cell differentiation
GO:0045766 positive regulation of angiogenesis
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048514 blood vessel morphogenesis
GO:0051216 cartilage development
GO:0060389 pathway-restricted SMAD protein phosphorylation
GO:0060395 SMAD protein signal transduction
GO:0061036 positive regulation of cartilage development
GO:0070062 extracellular exosome
GO:0071773 cellular response to BMP stimulus
GO:2000279 negative regulation of DNA biosynthetic process

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR001111 TGF-beta, propeptideDomainDomain
IPR001839 Transforming growth factor-beta, C-terminalDomainDomain
IPR015615 Transforming growth factor-beta-relatedFamilyFamily
IPR017948 Transforming growth factor beta, conserved siteSiteConserved site
IPR029034 Cystine-knot cytokineFamilyHomologous superfamily

Diseases

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