Entity Details

Primary name YETS2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9ULM3
EntryNameYETS2_HUMAN
FullNameYEATS domain-containing protein 2
TaxID9606
Evidenceevidence at protein level
Length1422
SequenceStatuscomplete
DateCreated2006-01-10
DateModified2021-06-02

Ontological Relatives

GenesYEATS2

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex
GO:0017025 TBP-class protein binding
GO:0042393 histone binding
GO:0043966 histone H3 acetylation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0072686 mitotic spindle
GO:0140030 modification-dependent protein binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR005033 YEATSFamilyFamily
IPR038704 YEATS superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
615127 OMIMEpilepsy, familial adult myoclonic, 4 (FAME4)A form of familial myoclonic epilepsy, a neurologic disorder characterized by cortical hand tremors, myoclonic jerks and occasional generalized or focal seizures with a non-progressive or very slowly progressive disease course. Usually, myoclonic tremor is the presenting symptom, characterized by tremulous finger movements and myoclonic jerks of the limbs increased by action and posture. In a minority of patients, seizures are the presenting symptom. Some patients exhibit mild cognitive impairment. FAME4 inheritance is autosomal dominant. The disease is caused by variants affecting the gene represented in this entry.