Entity Details

Primary name ATS5_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UNA0
EntryNameATS5_HUMAN
FullNameA disintegrin and metalloproteinase with thrombospondin motifs 5
TaxID9606
Evidenceevidence at protein level
Length930
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesADAMTS5

GO terms

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GOName
GO:0004175 endopeptidase activity
GO:0004222 metalloendopeptidase activity
GO:0005178 integrin binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005788 endoplasmic reticulum lumen
GO:0006508 proteolysis
GO:0007520 myoblast fusion
GO:0008201 heparin binding
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0022617 extracellular matrix disassembly
GO:0030198 extracellular matrix organization
GO:0031012 extracellular matrix
GO:0042742 defense response to bacterium
GO:0044691 tooth eruption
GO:0050840 extracellular matrix binding
GO:0062023 collagen-containing extracellular matrix
GO:0120163 negative regulation of cold-induced thermogenesis

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000884 Thrombospondin type-1 (TSP1) repeatRepeatRepeat
IPR001590 Peptidase M12B, ADAM/reprolysinDomainDomain
IPR002870 Peptidase M12B, propeptideDomainDomain
IPR006586 ADAM, cysteine-rich domainDomainDomain
IPR010294 ADAM-TS Spacer 1DomainDomain
IPR013273 ADAMTS/ADAMTS-likeFamilyFamily
IPR013276 Peptidase M12B, ADAM-TS5FamilyFamily
IPR024079 Metallopeptidase, catalytic domain superfamilyFamilyHomologous superfamily
IPR036383 Thrombospondin type-1 (TSP1) repeat superfamilyFamilyHomologous superfamily
IPR041645 ADAM cysteine-rich domain 2DomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB03880 BatimastatDrugbanksmall molecule
DB06837 (2R)-N~4~-hydroxy-2-(3-hydroxybenzyl)-N~1~-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamideDrugbanksmall molecule
DB06945 N-hydroxy-4-({4-[4-(trifluoromethyl)phenoxy]phenyl}sulfonyl)tetrahydro-2H-pyran-4-carboxamideDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
ATS5_HUMANMMP13_HUMANHPRD11032846 details
ATS5_HUMANPGCA_HUMANHPRD11854269 details