Entity Details

Primary name TFR2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UP52
EntryNameTFR2_HUMAN
FullNameTransferrin receptor protein 2
TaxID9606
Evidenceevidence at protein level
Length801
SequenceStatuscomplete
DateCreated2002-02-11
DateModified2021-06-02

Ontological Relatives

GenesTFR2

GO terms

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GOName
GO:0004998 transferrin receptor activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006826 iron ion transport
GO:0006879 cellular iron ion homeostasis
GO:0006898 receptor-mediated endocytosis
GO:0006953 acute-phase response
GO:0008235 metalloexopeptidase activity
GO:0009897 external side of plasma membrane
GO:0010039 response to iron ion
GO:0031410 cytoplasmic vesicle
GO:0033572 transferrin transport
GO:0039706 co-receptor binding
GO:0045807 positive regulation of endocytosis
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0055072 iron ion homeostasis
GO:0071281 cellular response to iron ion
GO:0090277 positive regulation of peptide hormone secretion
GO:0140298 endocytic iron import into cell
GO:1903319 positive regulation of protein maturation
GO:1990712 HFE-transferrin receptor complex

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm

Domains

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DomainNameCategoryType
IPR003137 PA domainDomainDomain
IPR007484 Peptidase M28DomainDomain
IPR036757 Transferrin receptor-like, dimerisation domain superfamilyFamilyHomologous superfamily
IPR037324 Transferrin receptor protein 1/2, PA domainDomainDomain
IPR039373 Glutamate carboxypeptidase 2-likeFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB05260 Gallium nitrateDrugbanksmall molecule
DB06784 Gallium citrate Ga-67Swissprotsmall molecule
DB13257 Ferrous sulfate anhydrousDrugbanksmall molecule
DB15617 Ferric derisomaltoseDrugbanksmall molecule