Entity Details

Primary name SOCS5_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO75159
EntryNameSOCS5_HUMAN
FullNameSuppressor of cytokine signaling 5
TaxID9606
Evidenceevidence at protein level
Length536
SequenceStatuscomplete
DateCreated2002-04-16
DateModified2021-06-02

Ontological Relatives

GenesSOCS5

GO terms

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GOName
GO:0005154 epidermal growth factor receptor binding
GO:0005829 cytosol
GO:0005942 phosphatidylinositol 3-kinase complex
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007175 negative regulation of epidermal growth factor-activated receptor activity
GO:0007259 receptor signaling pathway via JAK-STAT
GO:0009968 negative regulation of signal transduction
GO:0016567 protein ubiquitination
GO:0019221 cytokine-mediated signaling pathway
GO:0030971 receptor tyrosine kinase binding
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032715 negative regulation of interleukin-6 production
GO:0035556 intracellular signal transduction
GO:0040008 regulation of growth
GO:0043687 post-translational protein modification
GO:0045627 positive regulation of T-helper 1 cell differentiation
GO:0045629 negative regulation of T-helper 2 cell differentiation
GO:0046854 phosphatidylinositol phosphate biosynthetic process
GO:0046935 1-phosphatidylinositol-3-kinase regulator activity
GO:0050728 negative regulation of inflammatory response
GO:0071404 cellular response to low-density lipoprotein particle stimulus
GO:0071638 negative regulation of monocyte chemotactic protein-1 production
GO:0097699 vascular endothelial cell response to fluid shear stress

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000980 SH2 domainDomainDomain
IPR001496 SOCS box domainDomainDomain
IPR022252 SOCS4/SOCS5 domainDomainDomain
IPR028420 Suppressor of cytokine signalling 5FamilyFamily
IPR036036 SOCS box-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily
IPR037343 SOCS5, SOCS box domainDomainDomain

Diseases

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