Entity Details

Primary name LGR5_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO75473
EntryNameLGR5_HUMAN
FullNameLeucine-rich repeat-containing G-protein coupled receptor 5
TaxID9606
Evidenceevidence at protein level
Length907
SequenceStatuscomplete
DateCreated2002-06-20
DateModified2021-06-02

Ontological Relatives

GenesLGR5

GO terms

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GOName
GO:0001942 hair follicle development
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G protein-coupled receptor activity
GO:0005654 nucleoplasm
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007190 activation of adenylate cyclase activity
GO:0008528 G protein-coupled peptide receptor activity
GO:0009755 hormone-mediated signaling pathway
GO:0009994 oocyte differentiation
GO:0016500 protein-hormone receptor activity
GO:0032588 trans-Golgi network membrane
GO:0042127 regulation of cell population proliferation
GO:0048839 inner ear development
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:2001013 epithelial cell proliferation involved in renal tubule morphogenesis

Subcellular Location

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Subcellular Location
Cell membrane
Golgi apparatus

Domains

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DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR000372 Leucine-rich repeat N-terminal domainDomainDomain
IPR001611 Leucine-rich repeatRepeatRepeat
IPR002131 Glycoprotein hormone receptor familyFamilyFamily
IPR003591 Leucine-rich repeat, typical subtypeRepeatRepeat
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain
IPR032675 Leucine-rich repeat domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
LGR5_HUMANRSPO2_HUMANBioGRID29769720 details
LGR5_HUMANZNRF3_HUMANBioGRID26123262 details