Entity Details

Primary name AP2A2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO94973
EntryNameAP2A2_HUMAN
FullNameAP-2 complex subunit alpha-2
TaxID9606
Evidenceevidence at protein level
Length939
SequenceStatuscomplete
DateCreated2001-01-24
DateModified2021-06-02

Ontological Relatives

GenesAP2A2

GO terms

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GOName
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006886 intracellular protein transport
GO:0006898 receptor-mediated endocytosis
GO:0008289 lipid binding
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0019901 protein kinase binding
GO:0030122 AP-2 adaptor complex
GO:0030666 endocytic vesicle membrane
GO:0030667 secretory granule membrane
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:0032802 low-density lipoprotein particle receptor catabolic process
GO:0034383 low-density lipoprotein particle clearance
GO:0035615 clathrin adaptor activity
GO:0036020 endolysosome membrane
GO:0043312 neutrophil degranulation
GO:0045334 clathrin-coated endocytic vesicle
GO:0048013 ephrin receptor signaling pathway
GO:0050690 regulation of defense response to virus by virus
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0061024 membrane organization
GO:0072583 clathrin-dependent endocytosis
GO:0097718 disordered domain specific binding
GO:0101003 ficolin-1-rich granule membrane
GO:0140312 cargo adaptor activity

Subcellular Location

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Subcellular Location
Cell membrane
Membrane

Domains

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DomainNameCategoryType
IPR002553 Clathrin/coatomer adaptor, adaptin-like, N-terminalDomainDomain
IPR003164 Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomainDomainDomain
IPR008152 Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomainDomainDomain
IPR009028 Coatomer/calthrin adaptor appendage, C-terminal subdomainFamilyHomologous superfamily
IPR011989 Armadillo-like helicalFamilyHomologous superfamily
IPR012295 TBP domain superfamilyFamilyHomologous superfamily
IPR013041 Clathrin adaptor, appendage, Ig-like subdomain superfamilyFamilyHomologous superfamily
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR017104 Adaptor protein complex AP-2, alpha subunitFamilyFamily

Diseases

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Interactions

34 interactions

InteractorPartnerSourcesPublicationsLink
AP2A2_HUMANSMAD1_HUMANBioGRID, HPRD, MINT15231748 details
AP2A2_HUMANSHC1_HUMANBioGRID, HPRD, IntAct19380743 24189400 31980649 8617812 details
AP2A2_HUMANEPS15_HUMANBioGRID, HPRD, IntAct10809762 18362181 19380743 26822536 8662627 9049247 details
AP2A2_HUMANEGFR_HUMANBioGRID, IntAct23956138 24189400 24797263 31959764 8548289 details
AP2A2_HUMANHD_HUMANBioGRID, HPRD, IntAct17500595 9700202 details
AP2A2_HUMANCLH1_HUMANBioGRID, IntAct17052248 26496610 9280305 details
AP2A2_HUMANAAGAB_HUMANBioGRID, IntAct26186194 28514442 32296183 details
AP2A2_HUMANAMPH_HUMANBioGRID, HPRD, IntAct10748223 28514442 8552632 9195986 9280305 details
AP2A2_HUMANNLGN3_HUMANBioGRID, IntAct25464930 details
AP2A2_HUMANEPN1_HUMANBioGRID, HPRD12057195 9723620 details
AP2A2_HUMANA4_HUMANBioGRID21832049 details
AP2A2_HUMANUBC_HUMANBioGRID28190767 details
AP2A2_HUMANGTR8_HUMANBioGRID16723738 details
AP2A2_HUMANAP1S1_HUMANHPRD11707398 details
AP2A2_HUMANDAB2_HUMANBioGRID, UniProt11247302 22323290 details
AP2A2_HUMANNUMB_HUMANHPRD, IntAct17203073 23211419 details
AP2A2_HUMANOCRL_HUMANBioGRID, IntAct, MINT25107275 27173435 unassigned1312 details
AP2A2_HUMANTERF2_HUMANBioGRID20811636 details
AP2A2_HUMANBIN1_HUMANBioGRID, HPRD10430869 9195986 details
AP2A2_HUMANGRB2_HUMANBioGRID8552632 details
AP2A2_HUMANPI51C_HUMANBioGRID20435073 details
AP2A2_HUMANAT1A1_HUMANBioGRID20435073 details
AP2A2_HUMANAP2B1_HUMANBioGRID, HPRD12086608 26344197 34079125 details
AP2A2_HUMANYBOX1_HUMANBioGRID26343856 details
AP2A2_HUMANRN126_HUMANBioGRID26508657 details
AP2A2_HUMANUTP25_HUMANBioGRID26472760 details
AP2A2_HUMANMYO6_HUMANBioGRID26950368 29467281 details
AP2A2_HUMANTNR6A_HUMANBioGRID29395067 details
AP2A2_HUMANISG15_HUMANBioGRID33024031 details
AP2A2_HUMANTULP3_HUMANBioGRID33187986 details
AP2A2_HUMANDYN1_HUMANHPRD10430869 details
AP2A2_HUMANAP2A2_HUMANHPRD10430869 11707398 details
AP2A2_HUMANAP180_HUMANHPRD10430869 details
AP2A2_HUMANAUXI_HUMANHPRD11470803 details