Entity Details

Primary name FA9_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP00740
EntryNameFA9_HUMAN
FullNameCoagulation factor IX
TaxID9606
Evidenceevidence at protein level
Length461
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesF9

GO terms

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GOName
GO:0004175 endopeptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005788 endoplasmic reticulum lumen
GO:0005796 Golgi lumen
GO:0005886 plasma membrane
GO:0006508 proteolysis
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
GO:0007596 blood coagulation
GO:0007597 blood coagulation, intrinsic pathway
GO:0031638 zymogen activation
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000152 EGF-type aspartate/asparagine hydroxylation sitePTMPTM
IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domainDomainDomain
IPR000742 EGF-like domainDomainDomain
IPR001254 Serine proteases, trypsin domainDomainDomain
IPR001314 Peptidase S1A, chymotrypsin familyFamilyFamily
IPR001881 EGF-like calcium-binding domainDomainDomain
IPR009003 Peptidase S1, PA clanFamilyHomologous superfamily
IPR012224 Peptidase S1A, coagulation factor VII/IX/X/C/ZFamilyFamily
IPR017857 Coagulation factor-like, Gla domain superfamilyFamilyHomologous superfamily
IPR018097 EGF-like calcium-binding, conserved siteSiteConserved site
IPR018114 Serine proteases, trypsin family, histidine active siteSiteActive site
IPR033116 Serine proteases, trypsin family, serine active siteSiteActive site
IPR035694 Coagulation factor IXFamilyFamily
IPR035972 Gamma-carboxyglutamic acid-rich (GLA) domain superfamilyFamilyHomologous superfamily
IPR043504 Peptidase S1, PA clan, chymotrypsin-like foldFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00025 Antihemophilic factor, human recombinantDrugbankbiotech
DB00170 MenadioneDrugbanksmall molecule
DB05131 TTP889Drugbanksmall molecule
DB09109 Turoctocog alfaDrugbankbiotech
DB09332 KappadioneDrugbanksmall molecule
DB13150 Coagulation factor VII humanDrugbankbiotech
DB13151 Anti-inhibitor coagulant complexDrugbankbiotech
DB13192 Antihemophilic factor humanDrugbankbiotech
DB13923 EmicizumabDrugbankbiotech
DB13998 Lonoctocog alfaDrugbankbiotech
DB13999 Moroctocog alfaDrugbankbiotech
DB14738 Turoctocog alfa pegolDrugbankbiotech