Entity Details

Primary name EGF_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP01133
EntryNameEGF_HUMAN
FullNamePro-epidermal growth factor
TaxID9606
Evidenceevidence at protein level
Length1207
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesEGF

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000186 obsolete activation of MAPKK activity
GO:0000187 obsolete activation of MAPK activity
GO:0001525 angiogenesis
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002092 positive regulation of receptor internalization
GO:0002576 platelet degranulation
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005154 epidermal growth factor receptor binding
GO:0005509 calcium ion binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005765 lysosomal membrane
GO:0005886 plasma membrane
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0008083 growth factor activity
GO:0008284 positive regulation of cell population proliferation
GO:0010595 positive regulation of endothelial cell migration
GO:0010628 positive regulation of gene expression
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016021 integral component of membrane
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0021940 positive regulation of cerebellar granule cell precursor proliferation
GO:0030297 transmembrane receptor protein tyrosine kinase activator activity
GO:0030335 positive regulation of cell migration
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0031093 platelet alpha granule lumen
GO:0038029 epidermal growth factor receptor signaling pathway via MAPK cascade
GO:0038128 ERBB2 signaling pathway
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0042327 positive regulation of phosphorylation
GO:0043388 positive regulation of DNA binding
GO:0043406 positive regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0045740 positive regulation of DNA replication
GO:0045741 positive regulation of epidermal growth factor-activated receptor activity
GO:0045746 negative regulation of Notch signaling pathway
GO:0045840 positive regulation of mitotic nuclear division
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046425 regulation of receptor signaling pathway via JAK-STAT
GO:0048754 branching morphogenesis of an epithelial tube
GO:0051048 negative regulation of secretion
GO:0051897 positive regulation of protein kinase B signaling
GO:0060749 mammary gland alveolus development
GO:0061024 membrane organization
GO:0070062 extracellular exosome
GO:0070371 ERK1 and ERK2 cascade
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0090279 regulation of calcium ion import
GO:0090370 negative regulation of cholesterol efflux
GO:1900127 positive regulation of hyaluronan biosynthetic process
GO:1901185 negative regulation of ERBB signaling pathway
GO:1902966 positive regulation of protein localization to early endosome
GO:1905278 positive regulation of epithelial tube formation
GO:2000008 regulation of protein localization to cell surface
GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process
GO:2000145 regulation of cell motility

Subcellular Location

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Subcellular Location
Membrane

Domains

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DomainNameCategoryType
IPR000033 LDLR class B repeatRepeatRepeat
IPR000152 EGF-type aspartate/asparagine hydroxylation sitePTMPTM
IPR000742 EGF-like domainDomainDomain
IPR001881 EGF-like calcium-binding domainDomainDomain
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR011042 Six-bladed beta-propeller, TolB-likeFamilyHomologous superfamily
IPR016317 Pro-epidermal growth factorFamilyFamily
IPR018097 EGF-like calcium-binding, conserved siteSiteConserved site

Diseases

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Drugs

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DrugNameSourceType
DB00364 SucralfateDrugbanksmall molecule
DB04454 Alpha-Aminobutyric AcidDrugbanksmall molecule
DB08862 CholecystokininDrugbanksmall molecule
DB11973 TesevatinibDrugbanksmall molecule