Entity Details

Primary name IFNB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP01574
EntryNameIFNB_HUMAN
FullNameInterferon beta
TaxID9606
Evidenceevidence at protein level
Length187
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesIFNB1

GO terms

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GOName
GO:0002250 adaptive immune response
GO:0002286 T cell activation involved in immune response
GO:0002312 B cell activation involved in immune response
GO:0002323 natural killer cell activation involved in immune response
GO:0005125 cytokine activity
GO:0005132 type I interferon receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0006959 humoral immune response
GO:0007166 cell surface receptor signaling pathway
GO:0007596 blood coagulation
GO:0008811 chloramphenicol O-acetyltransferase activity
GO:0009615 response to virus
GO:0019221 cytokine-mediated signaling pathway
GO:0030101 natural killer cell activation
GO:0030183 B cell differentiation
GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein
GO:0035458 cellular response to interferon-beta
GO:0042100 B cell proliferation
GO:0043330 response to exogenous dsRNA
GO:0045071 negative regulation of viral genome replication
GO:0045089 positive regulation of innate immune response
GO:0045343 regulation of MHC class I biosynthetic process
GO:0045581 negative regulation of T cell differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0051607 defense response to virus
GO:0060337 type I interferon signaling pathway
GO:0071360 cellular response to exogenous dsRNA
GO:0098586 cellular response to virus
GO:2000552 negative regulation of T-helper 2 cell cytokine production
GO:2001235 positive regulation of apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000471 Interferon alpha/beta/deltaFamilyFamily
IPR009079 Four-helical cytokine-like, coreFamilyHomologous superfamily
IPR015588 Interferon betaFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB02379 Beta-D-GlucoseDrugbanksmall molecule

Interactions

4 interactions

InteractorPartnerSourcesPublicationsLink
IFNB_HUMANPEX19_HUMANBioGRID, IntAct32296183 details
IFNB_HUMANINAR1_HUMANBioGRID, HPRD, IntAct1834641 28514442 details
IFNB_HUMANIFNB_HUMANBioGRID, HPRD9342320 details
IFNB_HUMANINAR2_HUMANHPRD10395669 details