Entity Details

Primary name IL2RA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP01589
EntryNameIL2RA_HUMAN
FullNameInterleukin-2 receptor subunit alpha
TaxID9606
Evidenceevidence at protein level
Length272
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesIL2RA

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0002437 inflammatory response to antigenic stimulus
GO:0002664 regulation of T cell tolerance induction
GO:0004911 interleukin-2 receptor activity
GO:0005886 plasma membrane
GO:0005893 interleukin-2 receptor complex
GO:0006915 apoptotic process
GO:0006924 activation-induced cell death of T cells
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007166 cell surface receptor signaling pathway
GO:0007219 Notch signaling pathway
GO:0009897 external side of plasma membrane
GO:0019221 cytokine-mediated signaling pathway
GO:0019976 interleukin-2 binding
GO:0038110 interleukin-2-mediated signaling pathway
GO:0042104 positive regulation of activated T cell proliferation
GO:0042130 negative regulation of T cell proliferation
GO:0045582 positive regulation of T cell differentiation
GO:0045589 regulation of regulatory T cell differentiation
GO:0046013 regulation of T cell homeostatic proliferation
GO:0050728 negative regulation of inflammatory response

Subcellular Location

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Subcellular Location
Membrane

Domains

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DomainNameCategoryType
IPR000436 Sushi/SCR/CCP domainDomainDomain
IPR015486 Interleukin-2 receptor alphaFamilyFamily
IPR035976 Sushi/SCR/CCP superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00004 Denileukin diftitoxDrugbankbiotech
DB00041 AldesleukinDrugbankbiotech
DB00074 BasiliximabDrugbankbiotech
DB00111 DaclizumabDrugbankbiotech