Entity Details

Primary name ITB3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP05106
EntryNameITB3_HUMAN
FullNameIntegrin beta-3
TaxID9606
Evidenceevidence at protein level
Length788
SequenceStatuscomplete
DateCreated1987-08-13
DateModified2021-06-02

Ontological Relatives

GenesITGB3

GO terms

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GOName
GO:0001618 virus receptor activity
GO:0001934 positive regulation of protein phosphorylation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0001968 fibronectin binding
GO:0002020 protease binding
GO:0002576 platelet degranulation
GO:0003756 protein disulfide isomerase activity
GO:0005161 platelet-derived growth factor receptor binding
GO:0005178 integrin binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005911 cell-cell junction
GO:0005925 focal adhesion
GO:0007155 cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0007596 blood coagulation
GO:0008305 integrin complex
GO:0009986 cell surface
GO:0010595 positive regulation of endothelial cell migration
GO:0010745 negative regulation of macrophage derived foam cell differentiation
GO:0010888 negative regulation of lipid storage
GO:0014909 smooth muscle cell migration
GO:0015026 coreceptor activity
GO:0016477 cell migration
GO:0019899 enzyme binding
GO:0030168 platelet activation
GO:0030198 extracellular matrix organization
GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031092 platelet alpha granule membrane
GO:0031258 lamellipodium membrane
GO:0031527 filopodium membrane
GO:0031528 microvillus membrane
GO:0031589 cell-substrate adhesion
GO:0032147 activation of protein kinase activity
GO:0032369 negative regulation of lipid transport
GO:0032587 ruffle membrane
GO:0032880 regulation of protein localization
GO:0032991 protein-containing complex
GO:0033627 cell adhesion mediated by integrin
GO:0034113 heterotypic cell-cell adhesion
GO:0034446 substrate adhesion-dependent cell spreading
GO:0034683 integrin alphav-beta3 complex
GO:0035295 tube development
GO:0035866 alphav-beta3 integrin-PKCalpha complex
GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex
GO:0035868 alphav-beta3 integrin-HMGB1 complex
GO:0038027 apolipoprotein A-I-mediated signaling pathway
GO:0042060 wound healing
GO:0042470 melanosome
GO:0042802 identical protein binding
GO:0043184 vascular endothelial growth factor receptor 2 binding
GO:0043235 receptor complex
GO:0043277 apoptotic cell clearance
GO:0045124 regulation of bone resorption
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0046718 viral entry into host cell
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048333 mesodermal cell differentiation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050748 negative regulation of lipoprotein metabolic process
GO:0050839 cell adhesion molecule binding
GO:0050840 extracellular matrix binding
GO:0050900 leukocyte migration
GO:0050919 negative chemotaxis
GO:0051611 regulation of serotonin uptake
GO:0060055 angiogenesis involved in wound healing
GO:0070062 extracellular exosome
GO:0070527 platelet aggregation
GO:0071062 alphav-beta3 integrin-vitronectin complex
GO:0098978 glutamatergic synapse
GO:0099149 regulation of postsynaptic neurotransmitter receptor internalization
GO:1905598 negative regulation of low-density lipoprotein receptor activity

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cell projection

Domains

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DomainNameCategoryType
IPR002369 Integrin beta subunit, VWA domainDomainDomain
IPR012896 Integrin beta subunit, tailDomainDomain
IPR013111 EGF-like domain, extracellularDomainDomain
IPR014836 Integrin beta subunit, cytoplasmic domainDomainDomain
IPR015812 Integrin beta subunitFamilyFamily
IPR016201 PSI domainDomainDomain
IPR027068 Integrin beta-3 subunitFamilyFamily
IPR032695 Integrin domain superfamilyFamilyHomologous superfamily
IPR033760 Integrin beta N-terminalDomainDomain
IPR036349 Integrin beta tail domain superfamilyFamilyHomologous superfamily
IPR036465 von Willebrand factor A-like domain superfamilyFamilyHomologous superfamily
IPR040622 Integrin beta, epidermal growth factor-like domain 1DomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00054 AbciximabDrugbankbiotech
DB00063 EptifibatideDrugbankbiotech
DB00098 Antithymocyte immunoglobulin (rabbit)Drugbankbiotech
DB00451 LevothyroxineDrugbanksmall molecule
DB00775 TirofibanDrugbanksmall molecule
DB02709 ResveratrolDrugbanksmall molecule
DB04863 LefradafibanDrugbanksmall molecule
DB05787 LM-609Drugbankbiotech
DB06472 FradafibanDrugbanksmall molecule
DB13949 Ferric cationDrugbanksmall molecule
DB14520 Tetraferric tricitrate decahydrateDrugbanksmall molecule
DB15598 Ferric maltolDrugbanksmall molecule

Interactions

71 interactions

InteractorPartnerSourcesPublicationsLink
ITB3_HUMANITAV_HUMANBioGRID, DIP, HPRD, I2D, IntAct, MINT10891446 11546839 11884718 15299032 16099422 1694173 20639902 22178926 24658351 25792870 9686320 details
ITB3_HUMANEPS8_HUMANHPRD, MINT12606711 details
ITB3_HUMANRBGP1_HUMANMINT12606711 details
ITB3_HUMANANS1B_HUMANMINT12606711 details
ITB3_HUMANGULP1_HUMANMINT12606711 details
ITB3_HUMANRGS12_HUMANMINT12606711 details
ITB3_HUMANJIP1_HUMANMINT12606711 details
ITB3_HUMANTNS2_HUMANHPRD, MINT12606711 details
ITB3_HUMANITB3_HUMANDIP, HPRD, IntAct11606749 12606711 14681217 22178926 details
ITB3_HUMANITA2B_HUMANBioGRID, DIP, HPRD, IntAct, MINT10358085 10891446 11412103 11606749 1429573 14681217 15067009 15219201 15379538 17032655 18791937 19279667 19805198 22178926 25849143 30804189 9351872 details
ITB3_HUMANTLN1_HUMANBioGRID, HPRD, MINT10497223 11412103 11932255 12606711 16546176 19843520 details
ITB3_HUMANFINC_HUMANBioGRID, DIP, HPRD, IntAct11478883 1694173 24658351 24789099 details
ITB3_HUMANLYN_HUMANmbinfo14593208 details
ITB3_HUMANFIBG_HUMANBioGRID, HPRD, IntAct10747940 16877710 24789099 25398877 details
ITB3_HUMANX3CL1_HUMANIntAct23125415 24789099 details
ITB3_HUMANFLNA_HUMANBioGRID, DIP11807098 25849143 details
ITB3_HUMANFAK1_HUMANBioGRID11927607 19889638 9169439 details
ITB3_HUMANFLNB_HUMANBioGRID11807098 details
ITB3_HUMANCENPR_HUMANBioGRID, HPRD11864709 7593198 details
ITB3_HUMANTSP1_HUMANBioGRID, HPRD14963009 2478219 details
ITB3_HUMANFAK2_HUMANBioGRID, HPRD11683411 details
ITB3_HUMANPAXI_HUMANBioGRID11683411 details
ITB3_HUMANITA5_HUMANBioGRID, HPRD10358085 1694173 22470492 26344197 details
ITB3_HUMANPDIA1_HUMANBioGRID21670307 details
ITB3_HUMANPA24A_HUMANBioGRID18840708 details
ITB3_HUMANMK03_HUMANBioGRID23640055 details
ITB3_HUMANSHC1_HUMANBioGRID, HPRD10896934 10964917 19889638 details
ITB3_HUMANPA2GA_HUMANBioGRID18635536 details
ITB3_HUMANDOK1_HUMANBioGRID, HPRD12606711 19843520 details
ITB3_HUMANFIBA_HUMANBioGRID, HPRD11460491 9058485 details
ITB3_HUMANSRC_HUMANBioGRID, HPRD10896934 11723131 details
ITB3_HUMANAKT1_HUMANBioGRID, HPRD10896934 details
ITB3_HUMANPDK1_HUMANBioGRID10896934 details
ITB3_HUMANCDK1_HUMANBioGRID10896934 details
ITB3_HUMANFGFR1_HUMANBioGRID27371729 details
ITB3_HUMANA4_HUMANBioGRID27221710 details
ITB3_HUMANRASH_HUMANBioGRID30655611 details
ITB3_HUMANGRIA2_HUMANBioGRID22232691 details
ITB3_HUMANPTN1_HUMANMINT16115959 details
ITB3_HUMANPTN11_HUMANMINT12791772 details
ITB3_HUMANPTPRZ_HUMANBioGRID, I2D19141530 20639902 details
ITB3_HUMANILK_HUMANBioGRID, HPRD12372433 details
ITB3_HUMANPECA1_HUMANBioGRID, HPRD10982404 details
ITB3_HUMANPGFRB_HUMANBioGRID, HPRD10964931 details
ITB3_HUMANPGFRA_HUMANBioGRID, HPRD11953315 details
ITB3_HUMANCD36_HUMANBioGRID, HPRD11238109 details
ITB3_HUMANKSYK_HUMANBioGRID11042121 details
ITB3_HUMANEPHA2_HUMANBioGRID23874206 details
ITB3_HUMANVIME_HUMANBioGRID18840708 details
ITB3_HUMANKPCB_HUMANBioGRID18840708 details
ITB3_HUMANVGFR2_HUMANBioGRID, HPRD10022831 25644401 details
ITB3_HUMANPAK4_HUMANBioGRID23254288 details
ITB3_HUMANMMP2_HUMANBioGRID23254288 details
ITB3_HUMANITA4_HUMANBioGRID25792870 details
ITB3_HUMANITB1_HUMANBioGRID25792870 details
ITB3_HUMANCIB1_HUMANBioGRID24163826 details
ITB3_HUMANURP2_HUMANBioGRID25609252 details
ITB3_HUMANPTN_HUMANBioGRID19141530 details
ITB3_HUMANTGM2_HUMANHPRD10684262 details
ITB3_HUMANP2RY2_HUMANHPRD11331301 details
ITB3_HUMANDAB2_HUMANHPRD12606711 details
ITB3_HUMANDAB1_HUMANHPRD12606711 details
ITB3_HUMANNUMB_HUMANHPRD12606711 details
ITB3_HUMANPDPK1_HUMANHPRD10896934 details
ITB3_HUMANANGL3_HUMANHPRD11877390 details
ITB3_HUMANVTNC_HUMANHPRD16195248 details
ITB3_HUMANCAN1_HUMANHPRD7592818 details
ITB3_HUMANTHY1_HUMANHPRD15897908 details
ITB3_HUMANCO1A2_HUMANHPRD1693626 details
ITB3_HUMANNID1_HUMANHPRD8831898 9686320 details
ITB3_HUMANFBLN2_HUMANHPRD10848816 details