Entity Details

Primary name CP2E1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP05181
EntryNameCP2E1_HUMAN
FullNameCytochrome P450 2E1
TaxID9606
Evidenceevidence at protein level
Length493
SequenceStatuscomplete
DateCreated1987-08-13
DateModified2021-06-02

Ontological Relatives

GenesCYP2E1

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0002933 lipid hydroxylation
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0005737 cytoplasm
GO:0005743 mitochondrial inner membrane
GO:0005789 endoplasmic reticulum membrane
GO:0006082 organic acid metabolic process
GO:0006641 triglyceride metabolic process
GO:0006805 xenobiotic metabolic process
GO:0008202 steroid metabolic process
GO:0008392 arachidonic acid epoxygenase activity
GO:0008395 steroid hydroxylase activity
GO:0009617 response to bacterium
GO:0010193 response to ozone
GO:0010243 response to organonitrogen compound
GO:0016098 monoterpenoid metabolic process
GO:0016491 oxidoreductase activity
GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0017144 drug metabolic process
GO:0018601 4-nitrophenol 2-monooxygenase activity
GO:0018885 carbon tetrachloride metabolic process
GO:0018910 benzene metabolic process
GO:0018960 4-nitrophenol metabolic process
GO:0019373 epoxygenase P450 pathway
GO:0019825 oxygen binding
GO:0019899 enzyme binding
GO:0020037 heme binding
GO:0030544 Hsp70 protein binding
GO:0031227 intrinsic component of endoplasmic reticulum membrane
GO:0042197 halogenated hydrocarbon metabolic process
GO:0042738 exogenous drug catabolic process
GO:0042759 long-chain fatty acid biosynthetic process
GO:0043231 intracellular membrane-bounded organelle
GO:0045471 response to ethanol
GO:0046483 heterocycle metabolic process
GO:0051879 Hsp90 protein binding
GO:0070330 aromatase activity

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane
Microsome membrane
Mitochondrion inner membrane

Domains

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DomainNameCategoryType
IPR001128 Cytochrome P450FamilyFamily
IPR002401 Cytochrome P450, E-class, group IFamilyFamily
IPR008070 Cytochrome P450, E-class, group I, CYP2E-likeFamilyFamily
IPR017972 Cytochrome P450, conserved siteSiteConserved site
IPR036396 Cytochrome P450 superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00041 AldesleukinDrugbankbiotech
DB00109 EnfuvirtideDrugbankbiotech
DB00118 AdemetionineDrugbanksmall molecule
DB00184 NicotineDrugbanksmall molecule
DB00201 CaffeineDrugbanksmall molecule
DB00203 SildenafilDrugbanksmall molecule
DB00208 TiclopidineDrugbanksmall molecule
DB00228 EnfluraneDrugbanksmall molecule
DB00250 DapsoneDrugbanksmall molecule
DB00252 PhenytoinDrugbanksmall molecule
DB00255 DiethylstilbestrolDrugbanksmall molecule
DB00257 ClotrimazoleDrugbanksmall molecule
DB00259 SulfanilamideDrugbanksmall molecule
DB00277 TheophyllineDrugbanksmall molecule
DB00316 AcetaminophenDrugbanksmall molecule
DB00347 TrimethadioneDrugbanksmall molecule
DB00356 ChlorzoxazoneDrugbanksmall molecule
DB00379 MexiletineDrugbanksmall molecule
DB00428 StreptozocinDrugbanksmall molecule
DB00458 ImipramineDrugbanksmall molecule
DB00468 QuinineDrugbanksmall molecule
DB00477 ChlorpromazineDrugbanksmall molecule
DB00486 NabiloneDrugbanksmall molecule
DB00501 CimetidineDrugbanksmall molecule
DB00540 NortriptylineDrugbanksmall molecule
DB00549 ZafirlukastDrugbanksmall molecule
DB00586 DiclofenacDrugbanksmall molecule
DB00593 EthosuximideDrugbanksmall molecule
DB00617 ParamethadioneDrugbanksmall molecule
DB00622 NicardipineDrugbanksmall molecule
DB00623 FluphenazineDrugbanksmall molecule
DB00627 NiacinDrugbanksmall molecule
DB00633 DexmedetomidineDrugbanksmall molecule
DB00636 ClofibrateDrugbanksmall molecule
DB00655 EstroneDrugbanksmall molecule
DB00661 VerapamilDrugbanksmall molecule
DB00675 TamoxifenDrugbanksmall molecule
DB00679 ThioridazineDrugbanksmall molecule
DB00690 FlurazepamDrugbanksmall molecule
DB00752 TranylcypromineDrugbanksmall molecule
DB00753 IsofluraneDrugbanksmall molecule
DB00763 MethimazoleDrugbanksmall molecule
DB00773 EtoposideDrugbanksmall molecule
DB00780 PhenelzineDrugbanksmall molecule
DB00794 PrimidoneDrugbanksmall molecule
DB00818 PropofolDrugbanksmall molecule
DB00822 DisulfiramDrugbanksmall molecule
DB00829 DiazepamDrugbanksmall molecule
DB00851 DacarbazineDrugbanksmall molecule
DB00869 DorzolamideDrugbanksmall molecule
DB00883 Isosorbide dinitrateDrugbanksmall molecule
DB00898 EthanolDrugbanksmall molecule
DB00904 OndansetronDrugbanksmall molecule
DB00908 QuinidineDrugbanksmall molecule
DB00918 AlmotriptanDrugbanksmall molecule
DB00949 FelbamateDrugbanksmall molecule
DB00951 IsoniazidDrugbanksmall molecule
DB00969 AlosetronDrugbanksmall molecule
DB00972 AzelastineDrugbanksmall molecule
DB01007 TioconazoleDrugbanksmall molecule
DB01011 MetyraponeDrugbanksmall molecule
DB01028 MethoxyfluraneDrugbanksmall molecule
DB01037 SelegilineDrugbanksmall molecule
DB01041 ThalidomideDrugbanksmall molecule
DB01045 RifampicinDrugbanksmall molecule
DB01068 ClonazepamDrugbanksmall molecule
DB01079 TegaserodDrugbanksmall molecule
DB01104 SertralineDrugbanksmall molecule
DB01110 MiconazoleDrugbanksmall molecule
DB01115 NifedipineDrugbanksmall molecule
DB01127 EconazoleDrugbanksmall molecule
DB01136 CarvedilolDrugbanksmall molecule
DB01151 DesipramineDrugbanksmall molecule
DB01154 ThiamylalDrugbanksmall molecule
DB01156 BupropionDrugbanksmall molecule
DB01159 HalothaneDrugbanksmall molecule
DB01167 ItraconazoleDrugbanksmall molecule
DB01173 OrphenadrineDrugbanksmall molecule
DB01174 PhenobarbitalDrugbanksmall molecule
DB01191 DexfenfluramineDrugbanksmall molecule
DB01198 ZopicloneDrugbanksmall molecule
DB01204 MitoxantroneDrugbanksmall molecule
DB01213 FomepizoleDrugbanksmall molecule
DB01223 AminophyllineDrugbanksmall molecule
DB01234 DexamethasoneDrugbanksmall molecule
DB01236 SevofluraneDrugbanksmall molecule
DB01394 ColchicineDrugbanksmall molecule
DB01403 MethotrimeprazineDrugbanksmall molecule
DB01412 TheobromineDrugbanksmall molecule
DB01435 AntipyrineDrugbanksmall molecule
DB01544 FlunitrazepamDrugbanksmall molecule
DB01558 BromazepamDrugbanksmall molecule
DB01586 Ursodeoxycholic acidDrugbanksmall molecule
DB01595 NitrazepamDrugbanksmall molecule
DB01628 EtoricoxibDrugbanksmall molecule
DB01844 N,N-dimethylformamideDrugbanksmall molecule
DB02520 DitiocarbSwissprotsmall molecule
DB02701 NicotinamideDrugbanksmall molecule
DB03783 PhenacetinDrugbanksmall molecule
DB04379 N-Methyl-N-(Methylbenzyl)FormamideDrugbanksmall molecule
DB04794 BifonazoleDrugbanksmall molecule
DB04856 DexloxiglumideDrugbanksmall molecule
DB04858 TirapazamineSwissprotsmall molecule
DB04920 ClevidipineDrugbanksmall molecule
DB04946 IloperidoneDrugbanksmall molecule
DB04951 PirfenidoneSwissprotsmall molecule
DB04977 PlitidepsinSwissprotsmall molecule
DB05109 TrabectedinSwissprotsmall molecule
DB05708 GTS-21Drugbanksmall molecule
DB06119 CenobamateSwissprotsmall molecule
DB06201 RufinamideDrugbanksmall molecule
DB06370 IndisulamSwissprotsmall molecule
DB06448 LonafarnibDrugbanksmall molecule
DB06595 MidostaurinDrugbanksmall molecule
DB06637 DalfampridineDrugbanksmall molecule
DB06654 SafinamideDrugbanksmall molecule
DB06712 NilvadipineDrugbanksmall molecule
DB06728 AnilineDrugbanksmall molecule
DB06770 Benzyl alcoholSwissprotsmall molecule
DB06774 CapsaicinDrugbanksmall molecule
DB08846 Ellagic acidDrugbanksmall molecule
DB08868 FingolimodDrugbanksmall molecule
DB09120 ZucapsaicinDrugbanksmall molecule
DB09256 TegafurDrugbanksmall molecule
DB09288 PropacetamolDrugbanksmall molecule
DB09328 VayarinSwissprotbiotech
DB09462 GlycerinDrugbanksmall molecule
DB11689 SelumetinibDrugbanksmall molecule
DB11837 OsilodrostatDrugbanksmall molecule
DB11943 DelafloxacinDrugbanksmall molecule
DB11994 DiacereinDrugbanksmall molecule
DB12466 FavipiravirDrugbanksmall molecule
DB12499 ClascoteroneDrugbanksmall molecule
DB13174 RheinDrugbanksmall molecule
DB13609 UmifenovirSwissprotsmall molecule
DB13941 PiperaquineSwissprotsmall molecule
DB13963 1,2-dichlorobenzeneSwissprotsmall molecule
DB14046 DichlorobenzeneSwissprotsmall molecule
DB14649 Dexamethasone acetateDrugbanksmall molecule
DB14840 RipretinibDrugbanksmall molecule