Entity Details

Primary name TY3H_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP07101
EntryNameTY3H_HUMAN
FullNameTyrosine 3-monooxygenase
TaxID9606
Evidenceevidence at protein level
Length528
SequenceStatuscomplete
DateCreated1988-04-01
DateModified2021-06-02

Ontological Relatives

GenesTH

GO terms

Show/Hide Table
GOName
GO:0007507 heart development
GO:0005634 nucleus
GO:0007613 memory
GO:0009414 response to water deprivation
GO:0015842 aminergic neurotransmitter loading into synaptic vesicle
GO:0032496 response to lipopolysaccharide
GO:0042745 circadian sleep/wake cycle
GO:0042755 eating behavior
GO:0043005 neuron projection
GO:0042423 catecholamine biosynthetic process
GO:0051412 response to corticosterone
GO:0007605 sensory perception of sound
GO:0021987 cerebral cortex development
GO:0043195 terminal bouton
GO:0003007 heart morphogenesis
GO:0014823 response to activity
GO:0005737 cytoplasm
GO:0019899 enzyme binding
GO:0019904 protein domain specific binding
GO:0031667 response to nutrient levels
GO:0033076 isoquinoline alkaloid metabolic process
GO:0001975 response to amphetamine
GO:0016597 amino acid binding
GO:0042136 neurotransmitter biosynthetic process
GO:0001666 response to hypoxia
GO:0009651 response to salt stress
GO:0009887 animal organ morphogenesis
GO:0034617 tetrahydrobiopterin binding
GO:0035176 social behavior
GO:0042421 norepinephrine biosynthetic process
GO:0046684 response to pyrethroid
GO:0071363 cellular response to growth factor stimulus
GO:0005829 cytosol
GO:0033162 melanosome membrane
GO:0035902 response to immobilization stress
GO:0042214 terpene metabolic process
GO:0051602 response to electrical stimulus
GO:0071312 cellular response to alkaloid
GO:0030424 axon
GO:0071287 cellular response to manganese ion
GO:0005739 mitochondrion
GO:0006631 fatty acid metabolic process
GO:0008021 synaptic vesicle
GO:0009416 response to light stimulus
GO:0019825 oxygen binding
GO:0030425 dendrite
GO:0035240 dopamine binding
GO:0042462 eye photoreceptor cell development
GO:0043434 response to peptide hormone
GO:0004511 tyrosine 3-monooxygenase activity
GO:0007601 visual perception
GO:0009653 anatomical structure morphogenesis
GO:0042416 dopamine biosynthetic process
GO:0071316 cellular response to nicotine
GO:0010043 response to zinc ion
GO:0042802 identical protein binding
GO:0006585 dopamine biosynthetic process from tyrosine
GO:0035690 cellular response to drug
GO:1990384 hyaloid vascular plexus regression
GO:0042418 epinephrine biosynthetic process
GO:0008016 regulation of heart contraction
GO:0009898 cytoplasmic side of plasma membrane
GO:0010259 multicellular organism aging
GO:0006665 sphingolipid metabolic process
GO:0007617 mating behavior
GO:0016137 glycoside metabolic process
GO:0052314 phytoalexin metabolic process
GO:0001963 synaptic transmission, dopaminergic
GO:0007626 locomotory behavior
GO:0008198 ferrous iron binding
GO:0032355 response to estradiol
GO:0043473 pigmentation
GO:0045472 response to ether
GO:0048471 perinuclear region of cytoplasm
GO:0043204 perikaryon
GO:0048596 embryonic camera-type eye morphogenesis
GO:0005790 smooth endoplasmic reticulum
GO:0031410 cytoplasmic vesicle
GO:0007612 learning
GO:0008199 ferric iron binding
GO:0009635 response to herbicide
GO:0018963 phthalate metabolic process
GO:0035900 response to isolation stress
GO:0045471 response to ethanol
GO:0071333 cellular response to glucose stimulus

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm

Domains

Show/Hide Table
DomainNameCategoryType
IPR001273 Aromatic amino acid hydroxylaseFamilyFamily
IPR005962 Tyrosine 3-monooxygenaseFamilyFamily
IPR018301 Aromatic amino acid hydroxylase, iron/copper binding siteSiteBinding site
IPR019773 Tyrosine 3-monooxygenase-likeFamilyFamily
IPR019774 Aromatic amino acid hydroxylase, C-terminalDomainDomain
IPR021164 Tyrosine hydroxylase, conserved siteSiteConserved site
IPR036329 Aromatic amino acid monoxygenase, C-terminal domain superfamilyFamilyHomologous superfamily
IPR036951 Aromatic amino acid hydroxylase superfamilyFamilyHomologous superfamily
IPR041903 Tyrosine 3-monooxygenase, catalytic domainDomainDomain

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB00120 PhenylalanineDrugbanksmall molecule
DB00135 TyrosineDrugbanksmall molecule
DB00360 SapropterinDrugbanksmall molecule
DB00765 MetyrosineDrugbanksmall molecule
DB03552 3-TyrosineDrugbanksmall molecule
DB04400 L-erythro-7,8-dihydrobiopterinDrugbanksmall molecule