Entity Details

Primary name SYEP_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP07814
EntryNameSYEP_HUMAN
FullNameBifunctional glutamate/proline--tRNA ligase
TaxID9606
Evidenceevidence at protein level
Length1512
SequenceStatuscomplete
DateCreated1988-08-01
DateModified2021-06-02

Ontological Relatives

GenesEPRS1

GO terms

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GOName
GO:0004818 glutamate-tRNA ligase activity
GO:0004827 proline-tRNA ligase activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006418 tRNA aminoacylation for protein translation
GO:0006424 glutamyl-tRNA aminoacylation
GO:0006433 prolyl-tRNA aminoacylation
GO:0008270 zinc ion binding
GO:0016020 membrane
GO:0017101 aminoacyl-tRNA synthetase multienzyme complex
GO:0017148 negative regulation of translation
GO:0032869 cellular response to insulin stimulus
GO:0035613 RNA stem-loop binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0051020 GTPase binding
GO:0065003 protein-containing complex assembly
GO:0071346 cellular response to interferon-gamma
GO:0097452 GAIT complex
GO:0140212 regulation of long-chain fatty acid import into cell
GO:1990904 ribonucleoprotein complex

Subcellular Location

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Subcellular Location
Cytoplasm
Membrane

Domains

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DomainNameCategoryType
IPR000738 WHEP-TRS domainDomainDomain
IPR000924 Glutamyl/glutaminyl-tRNA synthetaseFamilyFamily
IPR001412 Aminoacyl-tRNA synthetase, class I, conserved siteSiteConserved site
IPR002314 Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)DomainDomain
IPR004046 Glutathione S-transferase, C-terminalDomainDomain
IPR004154 Anticodon-bindingDomainDomain
IPR004499 Proline-tRNA ligase, class IIa, archaeal-typeFamilyFamily
IPR004526 Glutamyl-tRNA synthetase, archaeal/eukaryotic cytosolicFamilyFamily
IPR006195 Aminoacyl-tRNA synthetase, class IIDomainDomain
IPR009068 S15/NS1, RNA-bindingFamilyHomologous superfamily
IPR011035 Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain superfamilyFamilyHomologous superfamily
IPR014729 Rossmann-like alpha/beta/alpha sandwich foldFamilyHomologous superfamily
IPR016061 Proline-tRNA ligase, class II, C-terminalDomainDomain
IPR017449 Prolyl-tRNA synthetase, class IIFamilyHomologous superfamily
IPR020056 Ribosomal protein L25/Gln-tRNA synthetase, N-terminalFamilyHomologous superfamily
IPR020058 Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domainDomainDomain
IPR020059 Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domainDomainDomain
IPR033721 Prolyl-tRNA synthetase, catalytic domainDomainDomain
IPR036282 Glutathione S-transferase, C-terminal domain superfamilyFamilyHomologous superfamily
IPR036621 Anticodon-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00142 Glutamic acidDrugbanksmall molecule
DB00172 ProlineDrugbanksmall molecule
DB02510 5'-O-(L-Prolylsulfamoyl)adenosineDrugbanksmall molecule
DB02684 5'-O-(L-Cysteinylsulfamoyl)adenosineDrugbanksmall molecule
DB03376 5'-O-(N-(Alanyl)sulfamoyl)adenosineDrugbanksmall molecule

Interactions

40 interactions

InteractorPartnerSourcesPublicationsLink
SYEP_HUMANSYIC_HUMANBioGRID, HPRD, IntAct, MINT, UniProt10913161 11142386 22863883 22939629 26344197 30021884 9556618 details
SYEP_HUMANHS90A_HUMANBioGRID, HPRD, MINT10913161 details
SYEP_HUMANARL4D_HUMANBioGRID, HPRD, IntAct16169070 details
SYEP_HUMANNELFD_HUMANBioGRID, HPRD, IntAct16169070 details
SYEP_HUMANEF1D_HUMANBioGRID, IntAct20195357 details
SYEP_HUMANSYRC_HUMANBioGRID, HPRD, IntAct22939629 26344197 28514442 31536960 9556618 details
SYEP_HUMANTAB1_HUMANBioGRID, MINT21900206 details
SYEP_HUMANESR1_HUMANBioGRID, IntAct20348541 25604459 details
SYEP_HUMANDUX4_HUMANBioGRID, IntAct26816005 details
SYEP_HUMANHSC20_HUMANBioGRID, DIP, IntAct24606901 28380382 details
SYEP_HUMANSYEP_HUMANDIP23263184 details
SYEP_HUMANNEDD4_HUMANBioGRID16055720 details
SYEP_HUMANCDC42_HUMANBioGRID22863883 31478661 details
SYEP_HUMANPTEN_HUMANBioGRID31685992 details
SYEP_HUMANSUMO2_HUMANBioGRID32786267 details
SYEP_HUMANIKBB_HUMANIntAct14743216 details
SYEP_HUMANIKBE_HUMANIntAct14743216 details
SYEP_HUMANIKKB_HUMANIntAct14743216 details
SYEP_HUMANNFKB2_HUMANIntAct14743216 details
SYEP_HUMANM3K14_HUMANIntAct14743216 details
SYEP_HUMANTF65_HUMANIntAct14743216 details
SYEP_HUMANRELB_HUMANIntAct14743216 details
SYEP_HUMANRIPK3_HUMANIntAct14743216 details
SYEP_HUMANM3K7_HUMANIntAct14743216 details
SYEP_HUMANATG12_HUMANIntAct17353931 details
SYEP_HUMAN1433Z_HUMANMINT15161933 details
SYEP_HUMANETS1_HUMANIntAct20195357 details
SYEP_HUMANMLP3A_HUMANBioGRID, IntAct20562859 22963397 details
SYEP_HUMANHNRPQ_HUMANDIP, HPRD, IntAct15479637 21220307 22386318 details
SYEP_HUMANSYK_HUMANBioGRID, DIP, IntAct21220307 22386318 22751010 22939629 26344197 28514442 31536960 details
SYEP_HUMANAIMP2_HUMANBioGRID, DIP, HPRD18695251 22939629 26344197 31792442 9878398 details
SYEP_HUMANHDAC5_HUMANBioGRID21081666 details
SYEP_HUMANITA4_HUMANBioGRID22623428 details
SYEP_HUMANEGFR_HUMANBioGRID23956138 details
SYEP_HUMANRN126_HUMANBioGRID26508657 details
SYEP_HUMANU2AF2_HUMANBioGRID26641092 details
SYEP_HUMANCA131_HUMANBioGRID26472760 details
SYEP_HUMANMYO6_HUMANBioGRID26950368 details
SYEP_HUMANISG15_HUMANBioGRID33024031 details
SYEP_HUMANDUS2L_HUMANHPRD15994936 details