Entity Details

Primary name MMP2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP08253
EntryNameMMP2_HUMAN
FullName72 kDa type IV collagenase
TaxID9606
Evidenceevidence at protein level
Length660
SequenceStatuscomplete
DateCreated1988-08-01
DateModified2021-06-02

Ontological Relatives

GenesMMP2

GO terms

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GOName
GO:0001525 angiogenesis
GO:0001666 response to hypoxia
GO:0001955 blood vessel maturation
GO:0001957 intramembranous ossification
GO:0004175 endopeptidase activity
GO:0004222 metalloendopeptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005886 plasma membrane
GO:0006508 proteolysis
GO:0007566 embryo implantation
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0019221 cytokine-mediated signaling pathway
GO:0022617 extracellular matrix disassembly
GO:0030017 sarcomere
GO:0030198 extracellular matrix organization
GO:0030574 collagen catabolic process
GO:0034614 cellular response to reactive oxygen species
GO:0035987 endodermal cell differentiation
GO:0044267 cellular protein metabolic process
GO:0048013 ephrin receptor signaling pathway
GO:0048771 tissue remodeling
GO:0060325 face morphogenesis
GO:0060346 bone trabecula formation
GO:0062023 collagen-containing extracellular matrix
GO:0071230 cellular response to amino acid stimulus
GO:0071492 cellular response to UV-A
GO:1904645 response to amyloid-beta
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation

Subcellular Location

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Subcellular Location
Cytoplasm
Membrane
Mitochondrion
Nucleus
Secreted

Domains

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DomainNameCategoryType
IPR000562 Fibronectin type II domainDomainDomain
IPR000585 Hemopexin-like domainDomainDomain
IPR001818 Peptidase M10, metallopeptidaseDomainDomain
IPR002477 Peptidoglycan binding-likeDomainDomain
IPR006026 Peptidase, metallopeptidaseDomainDomain
IPR013806 Kringle-like foldFamilyHomologous superfamily
IPR018486 Hemopexin, conserved siteSiteConserved site
IPR018487 Hemopexin-like repeatsRepeatRepeat
IPR021158 Peptidase M10A, cysteine switch, zinc binding siteSiteBinding site
IPR021190 Peptidase M10AFamilyFamily
IPR024079 Metallopeptidase, catalytic domain superfamilyFamilyHomologous superfamily
IPR028708 72kDa type IV collagenaseFamilyFamily
IPR033739 Peptidase M10A, catalytic domainDomainDomain
IPR036365 PGBD-like superfamilyFamilyHomologous superfamily
IPR036366 PGBD superfamilyFamilyHomologous superfamily
IPR036375 Hemopexin-like domain superfamilyFamilyHomologous superfamily
IPR036943 Fibronectin type II domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00786 MarimastatDrugbanksmall molecule
DB01197 CaptoprilDrugbanksmall molecule
DB01630 SC-74020Drugbanksmall molecule
DB04866 HalofuginoneDrugbanksmall molecule
DB05387 AE-941Drugbanksmall molecule
DB06423 EndostatinDrugbankbiotech

Interactions

48 interactions

InteractorPartnerSourcesPublicationsLink
MMP2_HUMANTIMP2_HUMANBioGRID, HPRD, IntAct10991943 12032297 12374789 28514442 9182583 9410885 9933646 details
MMP2_HUMANSCUB3_HUMANI2D21441952 details
MMP2_HUMANCAN3_HUMANBioGRID, IntAct23414517 details
MMP2_HUMANTGFB1_HUMANBioGRID, HPRD, IntAct10652271 25241761 details
MMP2_HUMANA2MG_HUMANBioGRID, HPRD, IntAct25241761 9344465 details
MMP2_HUMANCO5A1_HUMANBioGRID, IntAct, matrixdb20979576 28514442 details
MMP2_HUMANPCSK9_HUMANMINT25613181 details
MMP2_HUMANMTR1A_HUMANBioGRID, IntAct26514267 details
MMP2_HUMANMTR1B_HUMANBioGRID, IntAct26514267 details
MMP2_HUMANREL_HUMANBioGRID, IntAct32296183 details
MMP2_HUMANTIMP3_HUMANBioGRID, HPRD, IntAct10196161 28514442 7782289 details
MMP2_HUMANPCOC1_HUMANIntAct20207734 details
MMP2_HUMANA4_HUMANIntAct32814053 details
MMP2_HUMANCCL7_HUMANBioGRID, HPRD10947989 12149192 details
MMP2_HUMANPGCB_HUMANBioGRID, HPRD10986281 details
MMP2_HUMANCO1A1_HUMANBioGRID, HPRD11368514 details
MMP2_HUMANTIMP4_HUMANBioGRID, HPRD12374789 9182583 details
MMP2_HUMANTSP1_HUMANBioGRID, HPRD10900205 details
MMP2_HUMANTSP2_HUMANBioGRID, HPRD10900205 details
MMP2_HUMANPAK4_HUMANBioGRID23254288 details
MMP2_HUMANHS90A_HUMANBioGRID, HPRD, IntAct15146192 details
MMP2_HUMANBACE1_HUMANBioGRID, HPRD, IntAct12586836 25241761 details
MMP2_HUMANCOIA1_HUMANBioGRID, HPRD, IntAct12023034 28514442 details
MMP2_HUMANDISC1_HUMANIntAct31413325 details
MMP2_HUMANANXA2_HUMANUniProt31210752 details
MMP2_HUMANNGAL_HUMANBioGRID, HPRD7683678 details
MMP2_HUMANITAV_HUMANBioGRID, HPRD11134507 22349830 23254288 details
MMP2_HUMANITB1_HUMANBioGRID22349830 details
MMP2_HUMANITB3_HUMANBioGRID23254288 details
MMP2_HUMANSTAT3_HUMANBioGRID25219839 details
MMP2_HUMANHPLN1_HUMANHPRD7694569 details
MMP2_HUMANTIMP1_HUMANHPRD12475252 details
MMP2_HUMANCO7A1_HUMANHPRD10652000 details
MMP2_HUMANCO6A3_HUMANHPRD8862926 details
MMP2_HUMANFGFR1_HUMANHPRD8692946 details
MMP2_HUMANIBP3_HUMANHPRD7523391 details
MMP2_HUMANIL1B_HUMANHPRD8663297 details
MMP2_HUMANLEG3_HUMANHPRD7947821 details
MMP2_HUMANMMP14_HUMANHPRD14583471 8663332 details
MMP2_HUMANSDF1_HUMANHPRD11571304 details
MMP2_HUMANMMP17_HUMANHPRD10551873 details
MMP2_HUMANKISS1_HUMANHPRD12879005 details
MMP2_HUMANCLD1_HUMANHPRD11382769 details
MMP2_HUMANMMP25_HUMANHPRD14583471 8663332 details
MMP2_HUMANTICN1_HUMANHPRD12810672 details
MMP2_HUMANPGS2_HUMANHPRD9148753 details
MMP2_HUMANPGCA_HUMANHPRD7998967 details
MMP2_HUMANEPHB2_HUMANHPRD18713744 details