Entity Details

Primary name ODPA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP08559
EntryNameODPA_HUMAN
FullNamePyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length390
SequenceStatuscomplete
DateCreated1988-08-01
DateModified2021-06-02

Ontological Relatives

GenesPDHA1

GO terms

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GOName
GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005967 mitochondrial pyruvate dehydrogenase complex
GO:0006006 glucose metabolic process
GO:0006086 acetyl-CoA biosynthetic process from pyruvate
GO:0006090 pyruvate metabolic process
GO:0006099 tricarboxylic acid cycle
GO:0034604 pyruvate dehydrogenase (NAD+) activity
GO:0045254 pyruvate dehydrogenase complex
GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate

Subcellular Location

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Subcellular Location
Mitochondrion matrix

Domains

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DomainNameCategoryType
IPR001017 Dehydrogenase, E1 componentDomainDomain
IPR017597 Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup yFamilyFamily
IPR029061 Thiamin diphosphate-binding foldFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00157 NADHDrugbanksmall molecule