Entity Details

Primary name A2AP_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP08697
EntryNameA2AP_HUMAN
FullNameAlpha-2-antiplasmin
TaxID9606
Evidenceevidence at protein level
Length491
SequenceStatuscomplete
DateCreated1988-01-01
DateModified2021-06-02

Ontological Relatives

GenesSERPINF2

GO terms

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GOName
GO:0002020 protease binding
GO:0002034 maintenance of blood vessel diameter homeostasis by renin-angiotensin
GO:0002576 platelet degranulation
GO:0004866 endopeptidase inhibitor activity
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005576 extracellular region
GO:0005577 fibrinogen complex
GO:0005615 extracellular space
GO:0006953 acute-phase response
GO:0009986 cell surface
GO:0010033 response to organic substance
GO:0010757 negative regulation of plasminogen activation
GO:0010951 negative regulation of endopeptidase activity
GO:0030199 collagen fibril organization
GO:0031093 platelet alpha granule lumen
GO:0032967 positive regulation of collagen biosynthetic process
GO:0042730 fibrinolysis
GO:0042803 protein homodimerization activity
GO:0045597 positive regulation of cell differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046330 positive regulation of JNK cascade
GO:0048514 blood vessel morphogenesis
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0051496 positive regulation of stress fiber assembly
GO:0051918 negative regulation of fibrinolysis
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071636 positive regulation of transforming growth factor beta production
GO:0072562 blood microparticle
GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000215 Serpin familyFamilyFamily
IPR023795 Serpin, conserved siteSiteConserved site
IPR023796 Serpin domainDomainDomain
IPR033833 Alpha2-antiplasmin, serpin domainDomainDomain
IPR036186 Serpin superfamilyFamilyHomologous superfamily
IPR042178 Serpin superfamily, domain 1FamilyHomologous superfamily
IPR042185 Serpin superfamily, domain 2FamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB08888 OcriplasminDrugbankbiotech
DB09130 CopperDrugbanksmall molecule