Entity Details

Primary name RARA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP10276
EntryNameRARA_HUMAN
FullNameRetinoic acid receptor alpha
TaxID9606
Evidenceevidence at protein level
Length462
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesRARA

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001972 retinoic acid binding
GO:0003682 chromatin binding
GO:0003700 DNA-binding transcription factor activity
GO:0004879 nuclear receptor activity
GO:0005102 signaling receptor binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0008284 positive regulation of cell population proliferation
GO:0009755 hormone-mediated signaling pathway
GO:0009986 cell surface
GO:0015629 actin cytoskeleton
GO:0019899 enzyme binding
GO:0019904 protein domain specific binding
GO:0030154 cell differentiation
GO:0030851 granulocyte differentiation
GO:0030853 negative regulation of granulocyte differentiation
GO:0031490 chromatin DNA binding
GO:0032526 response to retinoic acid
GO:0032689 negative regulation of interferon-gamma production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032736 positive regulation of interleukin-13 production
GO:0032753 positive regulation of interleukin-4 production
GO:0032754 positive regulation of interleukin-5 production
GO:0032991 protein-containing complex
GO:0043277 apoptotic cell clearance
GO:0043422 protein kinase B binding
GO:0044323 retinoic acid-responsive element binding
GO:0045630 positive regulation of T-helper 2 cell differentiation
GO:0045787 positive regulation of cell cycle
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048384 retinoic acid receptor signaling pathway
GO:0051018 protein kinase A binding
GO:0051099 positive regulation of binding
GO:0051393 alpha-actinin binding
GO:0071391 cellular response to estrogen stimulus
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000536 Nuclear hormone receptor, ligand-binding domainDomainDomain
IPR001628 Zinc finger, nuclear hormone receptor-typeDomainDomain
IPR001723 Nuclear hormone receptorFamilyFamily
IPR003078 Retinoic acid receptorFamilyFamily
IPR013088 Zinc finger, NHR/GATA-typeFamilyHomologous superfamily
IPR035500 Nuclear hormone receptor-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00210 AdapaleneDrugbanksmall molecule
DB00459 AcitretinDrugbanksmall molecule
DB00523 AlitretinoinDrugbanksmall molecule
DB00755 TretinoinDrugbanksmall molecule
DB00799 TazaroteneDrugbanksmall molecule
DB00926 EtretinateDrugbanksmall molecule
DB00982 IsotretinoinDrugbanksmall molecule
DB04942 TamibaroteneDrugbanksmall molecule
DB05785 LGD-1550Drugbanksmall molecule
DB12808 TrifaroteneDrugbanksmall molecule

Interactions

151 interactions

InteractorPartnerSourcesPublicationsLink
RARA_HUMANPNRC2_HUMANHPRD, MINT11574675 details
RARA_HUMANRXRA_HUMANBioGRID, DIP, HPRD, IntAct, MINT10698945 10882070 12052862 1310351 1314167 14521715 15171703 15528208 15604093 16224062 16540467 16769902 17641689 19345331 21478865 21988832 22539306 25241761 25303530 31700049 7705655 9121466 9415406 9582446 details
RARA_HUMANRXRG_HUMANBioGRID, HPRD, IntAct, MINT15604093 16189514 20211142 21516116 21988832 25303530 25416956 25910212 29892012 31515488 32296183 details
RARA_HUMANRXRB_HUMANBioGRID, HPRD, IntAct15604093 16189514 20211142 21988832 25303530 26871637 28514442 29892012 31515488 32296183 details
RARA_HUMANUBE3A_HUMANBioGRID, HPRD, IntAct16713569 details
RARA_HUMANNCOA3_HUMANBioGRID, HPRD, IntAct, MINT12665583 15604093 16456540 17475621 19144644 20413580 25303530 9192892 9346901 details
RARA_HUMANNCOA1_HUMANBioGRID, DIP, HPRD, MINT, UniProt10082574 10454579 10760302 12138096 12665583 16456540 16606617 17363140 17475621 17641689 20338915 20543827 21478865 23975195 9121466 9192892 details
RARA_HUMANMED25_HUMANBioGRID, HPRD, MINT17641689 details
RARA_HUMANMED1_HUMANBioGRID, DIP, HPRD, IntAct, MINT, UniProt10760302 17641689 21478865 25303530 9653119 details
RARA_HUMANNRIP1_HUMANBioGRID, HPRD, IntAct, MINT10082574 10531331 12503607 12549917 14581481 16713569 17641689 25416956 8887632 details
RARA_HUMANPNRC1_HUMANMINT17641689 details
RARA_HUMANFINC_HUMANBioGRID, IntAct21988832 details
RARA_HUMANNCOR1_HUMANBioGRID, DIP, HPRD, IntAct, UniProt10336495 10882117 15336696 15604093 16469706 16606617 18978041 20543827 21988832 25303530 27107012 30532072 7566114 9121466 9486655 9531570 details
RARA_HUMANMK06_HUMANBioGRID, MINT21900206 details
RARA_HUMANSNW1_HUMANBioGRID, HPRD, UniProt19934264 9632709 details
RARA_HUMANSIR1_HUMANBioGRID, UniProt19934264 details
RARA_HUMANASXL1_HUMANUniProt16606617 details
RARA_HUMANPHF8_HUMANBioGRID, IntAct20548336 23518351 details
RARA_HUMANAKT1_HUMANBioGRID, Molecular Connections16417524 23693014 details
RARA_HUMANITBP2_HUMANBioGRID, HPRD, IntAct15604093 25036637 details
RARA_HUMANTEKT4_HUMANBioGRID, IntAct25416956 31515488 details
RARA_HUMANESR1_HUMANHPRD, IntAct17641689 25303530 25604459 9717844 details
RARA_HUMANMK01_HUMANBioGRID, IntAct12048211 25303530 details
RARA_HUMANNCOR2_HUMANBioGRID, DIP, HPRD, IntAct10082574 11929748 15604093 16219912 17475621 20543827 25303530 7566127 9256429 9380707 9415406 details
RARA_HUMANPPARG_HUMANBioGRID, IntAct32296183 details
RARA_HUMANBBS4_HUMANBioGRID, IntAct32296183 details
RARA_HUMANALX1_HUMANBioGRID, IntAct32296183 details
RARA_HUMANPKHF2_HUMANBioGRID, IntAct32296183 details
RARA_HUMANLX15B_HUMANBioGRID, IntAct32296183 details
RARA_HUMANNR2C1_HUMANBioGRID, IntAct32296183 details
RARA_HUMANMCRS1_HUMANBioGRID, IntAct32296183 details
RARA_HUMANCCDB1_HUMANBioGRID, IntAct32296183 details
RARA_HUMANARI5A_HUMANBioGRID, UniProt15941852 details
RARA_HUMANCCNH_HUMANDIP16769902 details
RARA_HUMANNCOA2_HUMANBioGRID, DIP12503607 12612084 20543827 9192892 9430642 details
RARA_HUMANACTN4_HUMANBioGRID, DIP22351778 details
RARA_HUMANBECN1_HUMANIntAct32814053 details
RARA_HUMANOPTN_HUMANIntAct32814053 details
RARA_HUMANHAIR_HUMANBioGRID, IntAct20211142 details
RARA_HUMANNRBF2_HUMANBioGRID, HPRD10786636 details
RARA_HUMANZBT16_HUMANBioGRID, HPRD14521715 details
RARA_HUMANMECR_HUMANBioGRID, HPRD9795230 details
RARA_HUMANNCOA6_HUMANBioGRID, HPRD10567404 10823961 10866662 11158331 details
RARA_HUMANGA45G_HUMANBioGRID, HPRD10872826 details
RARA_HUMANKAT2B_HUMANBioGRID, HPRD14581481 17475621 9445475 details
RARA_HUMANHDAC3_HUMANBioGRID12943985 details
RARA_HUMANHDAC4_HUMANBioGRID12943985 details
RARA_HUMANTDG_HUMANBioGRID12874288 24394593 details
RARA_HUMANPML_HUMANBioGRID, HPRD10610177 10882117 11050004 12935927 1311253 16540467 17560333 18073335 20159610 details
RARA_HUMANTRIP4_HUMANBioGRID, HPRD10454579 details
RARA_HUMANKDM5A_HUMANBioGRID, HPRD11358960 details
RARA_HUMANPO2F1_HUMANBioGRID, HPRD10480874 details
RARA_HUMANNR0B2_HUMANBioGRID, HPRD8650544 9773978 details
RARA_HUMANBAG1_HUMANBioGRID, HPRD9642262 details
RARA_HUMANTADA3_HUMANBioGRID, HPRD12235159 20413580 details
RARA_HUMANNKX21_HUMANBioGRID, HPRD10617585 11274148 details
RARA_HUMANTIF1A_HUMANBioGRID, HPRD12503607 8598193 9115274 details
RARA_HUMANIRX4_HUMANBioGRID, HPRD11382777 details
RARA_HUMANSP1_HUMANBioGRID, HPRD10361124 18270252 19401466 details
RARA_HUMANNPAS2_HUMANBioGRID, HPRD11439184 details
RARA_HUMANCLOCK_HUMANBioGRID11439184 details
RARA_HUMANBMAL1_HUMANBioGRID11439184 details
RARA_HUMANNR2E3_HUMANBioGRID, HPRD10611353 details
RARA_HUMANCCND3_HUMANBioGRID, HPRD12482873 details
RARA_HUMANSRC_HUMANBioGRID12612084 17641689 details
RARA_HUMANAJUBA_HUMANBioGRID20133701 details
RARA_HUMANPIN1_HUMANBioGRID15670742 details
RARA_HUMANPRS8_HUMANBioGRID12503607 19144644 8598193 8603043 details
RARA_HUMANTOP2B_HUMANBioGRID18212063 details
RARA_HUMANHMGA1_HUMANBioGRID10428834 details
RARA_HUMANRARA_HUMANBioGRID18073335 20807888 27419624 details
RARA_HUMANLRIF1_HUMANBioGRID17455211 details
RARA_HUMANKLF5_HUMANBioGRID, HPRD12101409 16102021 16224062 18466769 21383775 details
RARA_HUMANSMRD3_HUMANBioGRID17363140 details
RARA_HUMANARI1A_HUMANBioGRID17363140 details
RARA_HUMANPRDX6_HUMANBioGRID, HPRD15604093 details
RARA_HUMANNR1H2_HUMANBioGRID, HPRD15604093 details
RARA_HUMANFOXO1_HUMANBioGRID, HPRD11353774 details
RARA_HUMANTNIP1_HUMANBioGRID19732752 details
RARA_HUMANUBQL1_HUMANBioGRID20693704 details
RARA_HUMANPRAME_HUMANBioGRID16179254 details
RARA_HUMANUBP7_HUMANBioGRID23208507 details
RARA_HUMANMMS19_HUMANBioGRID11279242 details
RARA_HUMANE2F1_HUMANBioGRID24608861 details
RARA_HUMANCEBPA_HUMANBioGRID23898169 details
RARA_HUMANHDAC1_HUMANBioGRID23898169 details
RARA_HUMANNSD1_HUMANBioGRID, HPRD23975195 9628876 details
RARA_HUMANSRF_HUMANBioGRID11641790 details
RARA_HUMANMDM2_HUMANBioGRID26776160 details
RARA_HUMANFGFR1_HUMANBioGRID22539306 details
RARA_HUMANTRIB3_HUMANBioGRID28486108 details
RARA_HUMANS10A3_HUMANBioGRID30532072 details
RARA_HUMANCSN2_HUMANHPRD10207062 details
RARA_HUMANGATA2_HUMANHPRD15254248 details
RARA_HUMANCNOT1_HUMANHPRD16778766 details
RARA_HUMANTHB_HUMANHPRD17641689 details
RARA_HUMANGCR_HUMANHPRD17641689 details
RARA_HUMANCDK7_HUMANHPRD15249124 details
RARA_HUMANMBD1_HUMANIntAct16432238 details
RARA_HUMANMAGB2_HUMANIntAct17353931 details
RARA_HUMANHNRPL_HUMANIntAct17353931 details
RARA_HUMANEZH2_HUMANBioGRID, IntAct17560333 details
RARA_HUMANZN423_HUMANIntAct19345331 details
RARA_HUMANGNAQ_HUMANI2D22056876 details
RARA_HUMANSUMO1_HUMANMINT24819975 details
RARA_HUMANPRKDC_HUMANIntAct25303530 details
RARA_HUMANPARP1_HUMANBioGRID, HPRD, IntAct15808511 25303530 details
RARA_HUMANRARB_HUMANBioGRID, IntAct22022577 28514442 details
RARA_HUMANNF2L2_HUMANDIP18048326 details
RARA_HUMANGA45A_HUMANBioGRID10872826 details
RARA_HUMANLIMD1_HUMANBioGRID20133701 details
RARA_HUMANWTIP_HUMANBioGRID20133701 details
RARA_HUMANSKI_HUMANBioGRID16424870 19341714 details
RARA_HUMANSUV91_HUMANBioGRID16449642 details
RARA_HUMANEP300_HUMANBioGRID11980644 17475621 details
RARA_HUMANMED6_HUMANBioGRID, HPRD15808511 details
RARA_HUMANSP130_HUMANBioGRID18212063 details
RARA_HUMANHNRPU_HUMANBioGRID18212063 details
RARA_HUMANRFC4_HUMANBioGRID18212063 details
RARA_HUMANNPM_HUMANBioGRID18212063 details
RARA_HUMANMRT4_HUMANBioGRID18212063 details
RARA_HUMANSNR40_HUMANBioGRID18212063 details
RARA_HUMANRUVB1_HUMANBioGRID18087039 details
RARA_HUMANRUNX1_HUMANBioGRID18073335 details
RARA_HUMANSIAH1_HUMANBioGRID18073335 details
RARA_HUMANHDAC2_HUMANBioGRID18073335 21383775 details
RARA_HUMANCBP_HUMANBioGRID17475621 18443043 details
RARA_HUMANSPI1_HUMANBioGRID20159610 details
RARA_HUMANTRI32_HUMANBioGRID21984809 details
RARA_HUMANHACE1_HUMANBioGRID19350571 details
RARA_HUMANSQSTM_HUMANBioGRID21187718 25973309 details
RARA_HUMANPRAM_HUMANBioGRID21803845 27419624 details
RARA_HUMANTNR6_HUMANBioGRID21803845 details
RARA_HUMANTBL1R_HUMANBioGRID16469706 details
RARA_HUMANSUZ12_HUMANBioGRID17560333 details
RARA_HUMANTMM54_HUMANBioGRID22982681 details
RARA_HUMANMBD3_HUMANBioGRID24821728 details
RARA_HUMANMTA2_HUMANBioGRID24821728 details
RARA_HUMANCBX5_HUMANBioGRID24821728 details
RARA_HUMANGRP75_HUMANBioGRID22022577 details
RARA_HUMANP85A_HUMANBioGRID17595318 details
RARA_HUMANPK3CG_HUMANBioGRID17595318 details
RARA_HUMANFABP5_HUMANBioGRID30532072 details
RARA_HUMANHSPB1_HUMANBioGRID30532072 details
RARA_HUMANTERA_HUMANBioGRID31700049 details
RARA_HUMANKPCA_HUMANHPRD12000751 details
RARA_HUMANSTA5B_HUMANHPRD11929748 details
RARA_HUMANNR1H3_HUMANHPRD10022764 details
RARA_HUMANMINT_HUMANHPRD11331609 details
RARA_HUMANNRIP2_HUMANHPRD10860982 details
RARA_HUMANBTG1_HUMANHPRD15674337 details