Entity Details

Primary name CP2C8_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP10632
EntryNameCP2C8_HUMAN
FullNameCytochrome P450 2C8
TaxID9606
Evidenceevidence at protein level
Length490
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesCYP2C8

GO terms

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GOName
GO:0002933 lipid hydroxylation
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0005737 cytoplasm
GO:0005789 endoplasmic reticulum membrane
GO:0006082 organic acid metabolic process
GO:0006805 xenobiotic metabolic process
GO:0008202 steroid metabolic process
GO:0008210 estrogen metabolic process
GO:0008392 arachidonic acid epoxygenase activity
GO:0008395 steroid hydroxylase activity
GO:0008401 retinoic acid 4-hydroxylase activity
GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0017144 drug metabolic process
GO:0019373 epoxygenase P450 pathway
GO:0020037 heme binding
GO:0034875 caffeine oxidase activity
GO:0042572 retinol metabolic process
GO:0042573 retinoic acid metabolic process
GO:0042738 exogenous drug catabolic process
GO:0042759 long-chain fatty acid biosynthetic process
GO:0043231 intracellular membrane-bounded organelle
GO:0046456 icosanoid biosynthetic process
GO:0070330 aromatase activity
GO:0070989 oxidative demethylation
GO:0097267 omega-hydroxylase P450 pathway
GO:0101020 estrogen 16-alpha-hydroxylase activity

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane
Microsome membrane

Domains

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DomainNameCategoryType
IPR001128 Cytochrome P450FamilyFamily
IPR002401 Cytochrome P450, E-class, group IFamilyFamily
IPR017972 Cytochrome P450, conserved siteSiteConserved site
IPR036396 Cytochrome P450 superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00169 CholecalciferolDrugbanksmall molecule
DB00184 NicotineDrugbanksmall molecule
DB00197 TroglitazoneDrugbanksmall molecule
DB00201 CaffeineDrugbanksmall molecule
DB00205 PyrimethamineDrugbanksmall molecule
DB00208 TiclopidineDrugbanksmall molecule
DB00214 TorasemideDrugbanksmall molecule
DB00227 LovastatinDrugbanksmall molecule
DB00250 DapsoneDrugbanksmall molecule
DB00252 PhenytoinDrugbanksmall molecule
DB00255 DiethylstilbestrolDrugbanksmall molecule
DB00257 ClotrimazoleDrugbanksmall molecule
DB00281 LidocaineDrugbanksmall molecule
DB00295 MorphineDrugbanksmall molecule
DB00307 BexaroteneDrugbanksmall molecule
DB00321 AmitriptylineDrugbanksmall molecule
DB00333 MethadoneDrugbanksmall molecule
DB00338 OmeprazoleDrugbanksmall molecule
DB00342 TerfenadineDrugbanksmall molecule
DB00343 DiltiazemDrugbanksmall molecule
DB00347 TrimethadioneDrugbanksmall molecule
DB00359 SulfadiazineDrugbanksmall molecule
DB00363 ClozapineDrugbanksmall molecule
DB00381 AmlodipineDrugbanksmall molecule
DB00398 SorafenibDrugbanksmall molecule
DB00402 EszopicloneDrugbanksmall molecule
DB00412 RosiglitazoneDrugbanksmall molecule
DB00418 SecobarbitalDrugbanksmall molecule
DB00421 SpironolactoneDrugbanksmall molecule
DB00439 CerivastatinDrugbanksmall molecule
DB00440 TrimethoprimDrugbanksmall molecule
DB00443 BetamethasoneDrugbanksmall molecule
DB00448 LansoprazoleDrugbanksmall molecule
DB00451 LevothyroxineDrugbanksmall molecule
DB00455 LoratadineDrugbanksmall molecule
DB00465 KetorolacDrugbanksmall molecule
DB00468 QuinineDrugbanksmall molecule
DB00471 MontelukastDrugbanksmall molecule
DB00481 RaloxifeneDrugbanksmall molecule
DB00482 CelecoxibDrugbanksmall molecule
DB00486 NabiloneDrugbanksmall molecule
DB00501 CimetidineDrugbanksmall molecule
DB00503 RitonavirDrugbanksmall molecule
DB00530 ErlotinibDrugbanksmall molecule
DB00531 CyclophosphamideDrugbanksmall molecule
DB00532 MephenytoinDrugbanksmall molecule
DB00533 RofecoxibDrugbanksmall molecule
DB00544 FluorouracilDrugbanksmall molecule
DB00549 ZafirlukastDrugbanksmall molecule
DB00554 PiroxicamDrugbanksmall molecule
DB00564 CarbamazepineDrugbanksmall molecule
DB00586 DiclofenacDrugbanksmall molecule
DB00588 Fluticasone propionateDrugbanksmall molecule
DB00603 Medroxyprogesterone acetateDrugbanksmall molecule
DB00604 CisaprideDrugbanksmall molecule
DB00608 ChloroquineDrugbanksmall molecule
DB00613 AmodiaquineDrugbanksmall molecule
DB00615 RifabutinDrugbanksmall molecule
DB00617 ParamethadioneDrugbanksmall molecule
DB00619 ImatinibDrugbanksmall molecule
DB00622 NicardipineDrugbanksmall molecule
DB00624 TestosteroneDrugbanksmall molecule
DB00625 EfavirenzDrugbanksmall molecule
DB00635 PrednisoneDrugbanksmall molecule
DB00641 SimvastatinDrugbanksmall molecule
DB00661 VerapamilDrugbanksmall molecule
DB00675 TamoxifenDrugbanksmall molecule
DB00678 LosartanDrugbanksmall molecule
DB00682 WarfarinDrugbanksmall molecule
DB00688 Mycophenolate mofetilDrugbanksmall molecule
DB00714 ApomorphineDrugbanksmall molecule
DB00741 HydrocortisoneDrugbanksmall molecule
DB00755 TretinoinDrugbanksmall molecule
DB00758 ClopidogrelDrugbanksmall molecule
DB00764 MometasoneDrugbanksmall molecule
DB00780 PhenelzineDrugbanksmall molecule
DB00783 EstradiolDrugbanksmall molecule
DB00784 Mefenamic acidDrugbanksmall molecule
DB00788 NaproxenDrugbanksmall molecule
DB00796 Candesartan cilexetilDrugbanksmall molecule
DB00799 TazaroteneDrugbanksmall molecule
DB00814 MeloxicamDrugbanksmall molecule
DB00818 PropofolDrugbanksmall molecule
DB00829 DiazepamDrugbanksmall molecule
DB00834 MifepristoneDrugbanksmall molecule
DB00836 LoperamideDrugbanksmall molecule
DB00845 ClofazimineDrugbanksmall molecule
DB00850 PerphenazineDrugbanksmall molecule
DB00857 TerbinafineDrugbanksmall molecule
DB00897 TriazolamDrugbanksmall molecule
DB00907 CocaineDrugbanksmall molecule
DB00908 QuinidineDrugbanksmall molecule
DB00912 RepaglinideDrugbanksmall molecule
DB00916 MetronidazoleDrugbanksmall molecule
DB00918 AlmotriptanDrugbanksmall molecule
DB00921 BuprenorphineDrugbanksmall molecule
DB00938 SalmeterolDrugbanksmall molecule
DB00946 PhenprocoumonDrugbanksmall molecule
DB00951 IsoniazidDrugbanksmall molecule
DB00959 MethylprednisoloneDrugbanksmall molecule
DB00972 AzelastineDrugbanksmall molecule
DB00973 EzetimibeDrugbanksmall molecule
DB00977 EthinylestradiolDrugbanksmall molecule
DB01009 KetoprofenDrugbanksmall molecule
DB01023 FelodipineDrugbanksmall molecule
DB01026 KetoconazoleDrugbanksmall molecule
DB01029 IrbesartanDrugbanksmall molecule
DB01032 ProbenecidDrugbanksmall molecule
DB01037 SelegilineDrugbanksmall molecule
DB01039 FenofibrateDrugbanksmall molecule
DB01045 RifampicinDrugbanksmall molecule
DB01050 IbuprofenDrugbanksmall molecule
DB01060 AmoxicillinDrugbanksmall molecule
DB01062 OxybutyninDrugbanksmall molecule
DB01072 AtazanavirDrugbanksmall molecule
DB01076 AtorvastatinDrugbanksmall molecule
DB01079 TegaserodDrugbanksmall molecule
DB01095 FluvastatinDrugbanksmall molecule
DB01110 MiconazoleDrugbanksmall molecule
DB01115 NifedipineDrugbanksmall molecule
DB01118 AmiodaroneDrugbanksmall molecule
DB01124 TolbutamideDrugbanksmall molecule
DB01129 RabeprazoleDrugbanksmall molecule
DB01132 PioglitazoneDrugbanksmall molecule
DB01138 SulfinpyrazoneDrugbanksmall molecule
DB01174 PhenobarbitalDrugbanksmall molecule
DB01181 IfosfamideDrugbanksmall molecule
DB01184 DomperidoneDrugbanksmall molecule
DB01198 ZopicloneDrugbanksmall molecule
DB01201 RifapentineDrugbanksmall molecule
DB01217 AnastrozoleDrugbanksmall molecule
DB01218 HalofantrineDrugbanksmall molecule
DB01220 RifaximinDrugbanksmall molecule
DB01221 KetamineDrugbanksmall molecule
DB01222 BudesonideDrugbanksmall molecule
DB01229 PaclitaxelDrugbanksmall molecule
DB01232 SaquinavirDrugbanksmall molecule
DB01234 DexamethasoneDrugbanksmall molecule
DB01241 GemfibrozilDrugbanksmall molecule
DB01259 LapatinibDrugbanksmall molecule
DB01261 SitagliptinDrugbanksmall molecule
DB01357 MestranolDrugbanksmall molecule
DB01393 BezafibrateDrugbanksmall molecule
DB01394 ColchicineDrugbanksmall molecule
DB01424 AminophenazoneSwissprotsmall molecule
DB01435 AntipyrineDrugbanksmall molecule
DB01583 LiotrixDrugbanksmall molecule
DB01609 DeferasiroxSwissprotsmall molecule
DB01611 HydroxychloroquineDrugbanksmall molecule
DB01645 GenisteinDrugbanksmall molecule
DB01685 TopiroxostatDrugbanksmall molecule
DB03796 Palmitic AcidDrugbanksmall molecule
DB04216 QuercetinDrugbanksmall molecule
DB04725 LicofeloneDrugbanksmall molecule
DB04868 NilotinibDrugbanksmall molecule
DB05015 BelinostatDrugbanksmall molecule
DB05219 CrisaboroleDrugbanksmall molecule
DB05229 BeraprostDrugbanksmall molecule
DB05812 AbirateroneDrugbanksmall molecule
DB06077 LumateperoneDrugbanksmall molecule
DB06119 CenobamateSwissprotsmall molecule
DB06137 TirbanibulinDrugbanksmall molecule
DB06210 EltrombopagDrugbanksmall molecule
DB06448 LonafarnibDrugbanksmall molecule
DB06510 MuraglitazarDrugbanksmall molecule
DB06589 PazopanibDrugbanksmall molecule
DB06595 MidostaurinDrugbanksmall molecule
DB06605 ApixabanDrugbanksmall molecule
DB06616 BosutinibDrugbanksmall molecule
DB06670 OdanacatibDrugbanksmall molecule
DB06712 NilvadipineDrugbanksmall molecule
DB06729 SulfaphenazoleDrugbanksmall molecule
DB06738 KetobemidoneDrugbanksmall molecule
DB06739 SeratrodastDrugbanksmall molecule
DB06770 Benzyl alcoholSwissprotsmall molecule
DB06772 CabazitaxelDrugbanksmall molecule
DB08496 (R)-warfarinSwissprotsmall molecule
DB08502 CapravirineDrugbanksmall molecule
DB08607 (5R)-5-(4-{[(2R)-6-HYDROXY-2,5,7,8-TETRAMETHYL-3,4-DIHYDRO-2H-CHROMEN-2-YL]METHOXY}BENZYL)-1,3-THIAZOLIDINE-2,4-DIONEDrugbanksmall molecule
DB08828 VismodegibDrugbanksmall molecule
DB08860 PitavastatinDrugbanksmall molecule
DB08875 CabozantinibDrugbanksmall molecule
DB08880 TeriflunomideDrugbanksmall molecule
DB08881 VemurafenibDrugbanksmall molecule
DB08896 RegorafenibDrugbanksmall molecule
DB08899 EnzalutamideDrugbanksmall molecule
DB08901 PonatinibDrugbanksmall molecule
DB08906 Fluticasone furoateDrugbanksmall molecule
DB08911 TrametinibDrugbanksmall molecule
DB08912 DabrafenibDrugbanksmall molecule
DB08918 LevomilnacipranDrugbanksmall molecule
DB08922 PerospironeDrugbanksmall molecule
DB08931 RiociguatDrugbanksmall molecule
DB09054 IdelalisibDrugbanksmall molecule
DB09068 VortioxetineDrugbanksmall molecule
DB09078 LenvatinibDrugbanksmall molecule
DB09080 OlodaterolDrugbanksmall molecule
DB09183 DasabuvirDrugbanksmall molecule
DB09198 LobeglitazoneDrugbanksmall molecule
DB09199 NetoglitazoneSwissprotsmall molecule
DB09200 RivoglitazoneSwissprotsmall molecule
DB09201 CiglitazoneDrugbanksmall molecule
DB09213 DexibuprofenDrugbanksmall molecule
DB09241 Methylene blueDrugbanksmall molecule
DB09256 TegafurDrugbanksmall molecule
DB09280 LumacaftorDrugbanksmall molecule
DB09296 OmbitasvirDrugbanksmall molecule
DB09570 IxazomibSwissprotsmall molecule
DB11362 SelexipagDrugbanksmall molecule
DB11613 VelpatasvirDrugbanksmall molecule
DB11632 OpicaponeDrugbanksmall molecule
DB11633 IsavuconazoleDrugbanksmall molecule
DB11652 TucatinibDrugbanksmall molecule
DB11689 SelumetinibDrugbanksmall molecule
DB11753 RifamycinDrugbanksmall molecule
DB11757 IstradefyllineDrugbanksmall molecule
DB11853 RelugolixDrugbanksmall molecule
DB11901 ApalutamideDrugbanksmall molecule
DB11978 GlasdegibDrugbanksmall molecule
DB11979 ElagolixDrugbanksmall molecule
DB11995 AvatrombopagDrugbanksmall molecule
DB12001 AbemaciclibDrugbanksmall molecule
DB12015 AlpelisibDrugbanksmall molecule
DB12026 VoxilaprevirDrugbanksmall molecule
DB12070 LetermovirDrugbanksmall molecule
DB12130 LorlatinibDrugbanksmall molecule
DB12245 TriclabendazoleDrugbanksmall molecule
DB12267 BrigatinibDrugbanksmall molecule
DB12332 RucaparibDrugbanksmall molecule
DB12466 FavipiravirDrugbanksmall molecule
DB12499 ClascoteroneDrugbanksmall molecule
DB12612 OzanimodDrugbanksmall molecule
DB12781 BalaglitazoneSwissprotsmall molecule
DB12808 TrifaroteneDrugbanksmall molecule
DB13179 TroleandomycinDrugbanksmall molecule
DB13746 BioallethrinDrugbanksmall molecule
DB13867 FluticasoneDrugbanksmall molecule
DB13874 EnasidenibDrugbanksmall molecule
DB13919 CandesartanDrugbanksmall molecule
DB13943 Testosterone cypionateDrugbanksmall molecule
DB13944 Testosterone enanthateDrugbanksmall molecule
DB13946 Testosterone undecanoateDrugbanksmall molecule
DB13952 Estradiol acetateDrugbanksmall molecule
DB13953 Estradiol benzoateDrugbanksmall molecule
DB13954 Estradiol cypionateDrugbanksmall molecule
DB13955 Estradiol dienanthateDrugbanksmall molecule
DB13956 Estradiol valerateDrugbanksmall molecule
DB14055 (S)-WarfarinSwissprotsmall molecule
DB14512 Mometasone furoateDrugbanksmall molecule
DB14538 Hydrocortisone aceponateDrugbanksmall molecule
DB14539 Hydrocortisone acetateDrugbanksmall molecule
DB14540 Hydrocortisone butyrateDrugbanksmall molecule
DB14541 Hydrocortisone cypionateDrugbanksmall molecule
DB14542 Hydrocortisone phosphateDrugbanksmall molecule
DB14543 Hydrocortisone probutateDrugbanksmall molecule
DB14544 Hydrocortisone valerateDrugbanksmall molecule
DB14545 Hydrocortisone succinateSwissprotsmall molecule
DB14568 IvosidenibDrugbanksmall molecule
DB14631 Prednisolone phosphateDrugbanksmall molecule
DB14649 Dexamethasone acetateDrugbanksmall molecule
DB14761 RemdesivirDrugbanksmall molecule
DB14840 RipretinibDrugbanksmall molecule
DB15328 UbrogepantDrugbanksmall molecule
DB15444 ElexacaftorDrugbanksmall molecule
DB15685 SelpercatinibDrugbanksmall molecule
DB15822 PralsetinibDrugbanksmall molecule
DB15935 LumasiranDrugbankbiotech