Entity Details

Primary name CP2C9_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP11712
EntryNameCP2C9_HUMAN
FullNameCytochrome P450 2C9
TaxID9606
Evidenceevidence at protein level
Length490
SequenceStatuscomplete
DateCreated1989-10-01
DateModified2021-06-02

Ontological Relatives

GenesCYP2C9

GO terms

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GOName
GO:0008210 estrogen metabolic process
GO:0018676 (S)-limonene 7-monooxygenase activity
GO:0005737 cytoplasm
GO:0042737 drug catabolic process
GO:0008203 cholesterol metabolic process
GO:0008392 arachidonic acid epoxygenase activity
GO:0042738 exogenous drug catabolic process
GO:0008404 arachidonic acid 14,15-epoxygenase activity
GO:0043603 cellular amide metabolic process
GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0018675 (S)-limonene 6-monooxygenase activity
GO:0070330 aromatase activity
GO:0070989 oxidative demethylation
GO:0008405 arachidonic acid 11,12-epoxygenase activity
GO:0008395 steroid hydroxylase activity
GO:0046456 icosanoid biosynthetic process
GO:0006805 xenobiotic metabolic process
GO:0017144 drug metabolic process
GO:0005506 iron ion binding
GO:0016098 monoterpenoid metabolic process
GO:0019373 epoxygenase P450 pathway
GO:0020037 heme binding
GO:0008202 steroid metabolic process
GO:0016491 oxidoreductase activity
GO:0019627 urea metabolic process
GO:0097267 omega-hydroxylase P450 pathway
GO:0043231 intracellular membrane-bounded organelle
GO:0032787 monocarboxylic acid metabolic process
GO:0006082 organic acid metabolic process
GO:0034875 caffeine oxidase activity
GO:0042759 long-chain fatty acid biosynthetic process
GO:0052741 (R)-limonene 6-monooxygenase activity
GO:0004497 monooxygenase activity
GO:0005789 endoplasmic reticulum membrane

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane
Microsome membrane

Domains

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DomainNameCategoryType
IPR001128 Cytochrome P450FamilyFamily
IPR002401 Cytochrome P450, E-class, group IFamilyFamily
IPR017972 Cytochrome P450, conserved siteSiteConserved site
IPR036396 Cytochrome P450 superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00022 Peginterferon alfa-2bDrugbankbiotech
DB00176 FluvoxamineDrugbanksmall molecule
DB00177 ValsartanDrugbanksmall molecule
DB00184 NicotineDrugbanksmall molecule
DB00188 BortezomibDrugbanksmall molecule
DB00196 FluconazoleDrugbanksmall molecule
DB00197 TroglitazoneDrugbanksmall molecule
DB00201 CaffeineDrugbanksmall molecule
DB00203 SildenafilDrugbanksmall molecule
DB00208 TiclopidineDrugbanksmall molecule
DB00214 TorasemideDrugbanksmall molecule
DB00216 EletriptanDrugbanksmall molecule
DB00220 NelfinavirDrugbanksmall molecule
DB00222 GlimepirideDrugbanksmall molecule
DB00231 TemazepamDrugbanksmall molecule
DB00238 NevirapineDrugbanksmall molecule
DB00250 DapsoneDrugbanksmall molecule
DB00252 PhenytoinDrugbanksmall molecule
DB00255 DiethylstilbestrolDrugbanksmall molecule
DB00257 ClotrimazoleDrugbanksmall molecule
DB00263 SulfisoxazoleDrugbanksmall molecule
DB00266 DicoumarolDrugbanksmall molecule
DB00281 LidocaineDrugbanksmall molecule
DB00304 DesogestrelDrugbanksmall molecule
DB00313 Valproic acidDrugbanksmall molecule
DB00317 GefitinibDrugbanksmall molecule
DB00321 AmitriptylineDrugbanksmall molecule
DB00322 FloxuridineDrugbanksmall molecule
DB00323 TolcaponeDrugbanksmall molecule
DB00327 HydromorphoneDrugbanksmall molecule
DB00328 IndomethacinDrugbanksmall molecule
DB00333 MethadoneDrugbanksmall molecule
DB00334 OlanzapineDrugbanksmall molecule
DB00338 OmeprazoleDrugbanksmall molecule
DB00347 TrimethadioneDrugbanksmall molecule
DB00359 SulfadiazineDrugbanksmall molecule
DB00363 ClozapineDrugbanksmall molecule
DB00374 TreprostinilDrugbanksmall molecule
DB00396 ProgesteroneDrugbanksmall molecule
DB00398 SorafenibDrugbanksmall molecule
DB00404 AlprazolamDrugbanksmall molecule
DB00412 RosiglitazoneDrugbanksmall molecule
DB00414 AcetohexamideDrugbanksmall molecule
DB00418 SecobarbitalDrugbanksmall molecule
DB00420 PromazineDrugbanksmall molecule
DB00425 ZolpidemDrugbanksmall molecule
DB00439 CerivastatinDrugbanksmall molecule
DB00440 TrimethoprimDrugbanksmall molecule
DB00443 BetamethasoneDrugbanksmall molecule
DB00444 TeniposideDrugbanksmall molecule
DB00448 LansoprazoleDrugbanksmall molecule
DB00455 LoratadineDrugbanksmall molecule
DB00461 NabumetoneDrugbanksmall molecule
DB00465 KetorolacDrugbanksmall molecule
DB00468 QuinineDrugbanksmall molecule
DB00469 TenoxicamDrugbanksmall molecule
DB00470 DronabinolDrugbanksmall molecule
DB00471 MontelukastDrugbanksmall molecule
DB00472 FluoxetineDrugbanksmall molecule
DB00476 DuloxetineDrugbanksmall molecule
DB00482 CelecoxibDrugbanksmall molecule
DB00486 NabiloneDrugbanksmall molecule
DB00495 ZidovudineDrugbanksmall molecule
DB00501 CimetidineDrugbanksmall molecule
DB00502 HaloperidolDrugbanksmall molecule
DB00503 RitonavirDrugbanksmall molecule
DB00514 DextromethorphanDrugbanksmall molecule
DB00515 CisplatinDrugbanksmall molecule
DB00531 CyclophosphamideDrugbanksmall molecule
DB00532 MephenytoinDrugbanksmall molecule
DB00533 RofecoxibDrugbanksmall molecule
DB00544 FluorouracilDrugbanksmall molecule
DB00549 ZafirlukastDrugbanksmall molecule
DB00554 PiroxicamDrugbanksmall molecule
DB00559 BosentanDrugbanksmall molecule
DB00564 CarbamazepineDrugbanksmall molecule
DB00568 CinnarizineDrugbanksmall molecule
DB00574 FenfluramineDrugbanksmall molecule
DB00576 SulfamethizoleDrugbanksmall molecule
DB00580 ValdecoxibDrugbanksmall molecule
DB00582 VoriconazoleDrugbanksmall molecule
DB00586 DiclofenacDrugbanksmall molecule
DB00590 DoxazosinDrugbanksmall molecule
DB00603 Medroxyprogesterone acetateDrugbanksmall molecule
DB00604 CisaprideDrugbanksmall molecule
DB00613 AmodiaquineDrugbanksmall molecule
DB00615 RifabutinDrugbanksmall molecule
DB00617 ParamethadioneDrugbanksmall molecule
DB00619 ImatinibDrugbanksmall molecule
DB00621 OxandroloneDrugbanksmall molecule
DB00622 NicardipineDrugbanksmall molecule
DB00624 TestosteroneDrugbanksmall molecule
DB00625 EfavirenzDrugbanksmall molecule
DB00635 PrednisoneDrugbanksmall molecule
DB00641 SimvastatinDrugbanksmall molecule
DB00655 EstroneDrugbanksmall molecule
DB00661 VerapamilDrugbanksmall molecule
DB00668 EpinephrineDrugbanksmall molecule
DB00672 ChlorpropamideDrugbanksmall molecule
DB00673 AprepitantDrugbanksmall molecule
DB00675 TamoxifenDrugbanksmall molecule
DB00678 LosartanDrugbanksmall molecule
DB00682 WarfarinDrugbanksmall molecule
DB00701 AmprenavirDrugbanksmall molecule
DB00705 DelavirdineDrugbanksmall molecule
DB00712 FlurbiprofenDrugbanksmall molecule
DB00715 ParoxetineDrugbanksmall molecule
DB00726 TrimipramineDrugbanksmall molecule
DB00731 NateglinideDrugbanksmall molecule
DB00741 HydrocortisoneDrugbanksmall molecule
DB00744 ZileutonDrugbanksmall molecule
DB00745 ModafinilDrugbanksmall molecule
DB00749 EtodolacDrugbanksmall molecule
DB00752 TranylcypromineDrugbanksmall molecule
DB00755 TretinoinDrugbanksmall molecule
DB00757 DolasetronDrugbanksmall molecule
DB00758 ClopidogrelDrugbanksmall molecule
DB00763 MethimazoleDrugbanksmall molecule
DB00783 EstradiolDrugbanksmall molecule
DB00784 Mefenamic acidDrugbanksmall molecule
DB00788 NaproxenDrugbanksmall molecule
DB00794 PrimidoneDrugbanksmall molecule
DB00796 Candesartan cilexetilDrugbanksmall molecule
DB00812 PhenylbutazoneDrugbanksmall molecule
DB00814 MeloxicamDrugbanksmall molecule
DB00818 PropofolDrugbanksmall molecule
DB00829 DiazepamDrugbanksmall molecule
DB00834 MifepristoneDrugbanksmall molecule
DB00839 TolazamideDrugbanksmall molecule
DB00843 DonepezilDrugbanksmall molecule
DB00850 PerphenazineDrugbanksmall molecule
DB00857 TerbinafineDrugbanksmall molecule
DB00869 DorzolamideDrugbanksmall molecule
DB00870 SuprofenDrugbanksmall molecule
DB00891 SulfapyridineDrugbanksmall molecule
DB00898 EthanolDrugbanksmall molecule
DB00904 OndansetronDrugbanksmall molecule
DB00908 QuinidineDrugbanksmall molecule
DB00916 MetronidazoleDrugbanksmall molecule
DB00921 BuprenorphineDrugbanksmall molecule
DB00936 Salicylic acidDrugbanksmall molecule
DB00945 Acetylsalicylic acidDrugbanksmall molecule
DB00946 PhenprocoumonDrugbanksmall molecule
DB00949 FelbamateDrugbanksmall molecule
DB00951 IsoniazidDrugbanksmall molecule
DB00957 NorgestimateDrugbanksmall molecule
DB00959 MethylprednisoloneDrugbanksmall molecule
DB00969 AlosetronDrugbanksmall molecule
DB00972 AzelastineDrugbanksmall molecule
DB00977 EthinylestradiolDrugbanksmall molecule
DB00980 RamelteonDrugbanksmall molecule
DB00983 FormoterolDrugbanksmall molecule
DB01009 KetoprofenDrugbanksmall molecule
DB01015 SulfamethoxazoleDrugbanksmall molecule
DB01016 GlyburideDrugbanksmall molecule
DB01023 FelodipineDrugbanksmall molecule
DB01026 KetoconazoleDrugbanksmall molecule
DB01028 MethoxyfluraneDrugbanksmall molecule
DB01029 IrbesartanDrugbanksmall molecule
DB01032 ProbenecidDrugbanksmall molecule
DB01036 TolterodineDrugbanksmall molecule
DB01037 SelegilineDrugbanksmall molecule
DB01039 FenofibrateDrugbanksmall molecule
DB01041 ThalidomideDrugbanksmall molecule
DB01045 RifampicinDrugbanksmall molecule
DB01050 IbuprofenDrugbanksmall molecule
DB01065 MelatoninDrugbanksmall molecule
DB01067 GlipizideDrugbanksmall molecule
DB01069 PromethazineDrugbanksmall molecule
DB01072 AtazanavirDrugbanksmall molecule
DB01075 DiphenhydramineDrugbanksmall molecule
DB01076 AtorvastatinDrugbanksmall molecule
DB01080 VigabatrinDrugbanksmall molecule
DB01095 FluvastatinDrugbanksmall molecule
DB01097 LeflunomideDrugbanksmall molecule
DB01098 RosuvastatinDrugbanksmall molecule
DB01101 CapecitabineDrugbanksmall molecule
DB01104 SertralineDrugbanksmall molecule
DB01110 MiconazoleDrugbanksmall molecule
DB01115 NifedipineDrugbanksmall molecule
DB01117 AtovaquoneDrugbanksmall molecule
DB01118 AmiodaroneDrugbanksmall molecule
DB01120 GliclazideDrugbanksmall molecule
DB01124 TolbutamideDrugbanksmall molecule
DB01128 BicalutamideDrugbanksmall molecule
DB01129 RabeprazoleDrugbanksmall molecule
DB01131 ProguanilDrugbanksmall molecule
DB01136 CarvedilolDrugbanksmall molecule
DB01137 LevofloxacinDrugbanksmall molecule
DB01138 SulfinpyrazoneDrugbanksmall molecule
DB01142 DoxepinDrugbanksmall molecule
DB01154 ThiamylalDrugbanksmall molecule
DB01156 BupropionDrugbanksmall molecule
DB01159 HalothaneDrugbanksmall molecule
DB01171 MoclobemideDrugbanksmall molecule
DB01174 PhenobarbitalDrugbanksmall molecule
DB01176 CyclizineDrugbanksmall molecule
DB01177 IdarubicinDrugbanksmall molecule
DB01181 IfosfamideDrugbanksmall molecule
DB01195 FlecainideDrugbanksmall molecule
DB01198 ZopicloneDrugbanksmall molecule
DB01201 RifapentineDrugbanksmall molecule
DB01217 AnastrozoleDrugbanksmall molecule
DB01221 KetamineDrugbanksmall molecule
DB01222 BudesonideDrugbanksmall molecule
DB01241 GemfibrozilDrugbanksmall molecule
DB01251 GliquidoneDrugbanksmall molecule
DB01274 ArformoterolDrugbanksmall molecule
DB01283 LumiracoxibDrugbanksmall molecule
DB01289 GlisoxepideDrugbanksmall molecule
DB01320 FosphenytoinDrugbanksmall molecule
DB01355 HexobarbitalDrugbanksmall molecule
DB01357 MestranolDrugbanksmall molecule
DB01381 Ginkgo bilobaDrugbankbiotech
DB01411 PranlukastDrugbanksmall molecule
DB01418 AcenocoumarolDrugbanksmall molecule
DB01424 AminophenazoneSwissprotsmall molecule
DB01435 AntipyrineDrugbanksmall molecule
DB01544 FlunitrazepamDrugbanksmall molecule
DB01589 QuazepamDrugbanksmall molecule
DB01601 LopinavirDrugbanksmall molecule
DB01628 EtoricoxibDrugbanksmall molecule
DB01645 GenisteinDrugbanksmall molecule
DB01685 TopiroxostatDrugbanksmall molecule
DB03317 Ferroheme CDrugbanksmall molecule
DB03756 DoconexentDrugbanksmall molecule
DB03783 PhenacetinDrugbanksmall molecule
DB04557 Arachidonic AcidDrugbanksmall molecule
DB04574 Estrone sulfateDrugbanksmall molecule
DB04665 CoumarinDrugbanksmall molecule
DB04725 LicofeloneDrugbanksmall molecule
DB04818 IproniazidSwissprotsmall molecule
DB04831 Tienilic acidSwissprotsmall molecule
DB04841 FlunarizineDrugbanksmall molecule
DB04856 DexloxiglumideDrugbanksmall molecule
DB04868 NilotinibDrugbanksmall molecule
DB04898 XimelagatranDrugbanksmall molecule
DB04911 OritavancinSwissprotsmall molecule
DB04920 ClevidipineDrugbanksmall molecule
DB04938 OspemifeneDrugbanksmall molecule
DB04951 PirfenidoneSwissprotsmall molecule
DB05015 BelinostatDrugbanksmall molecule
DB05109 TrabectedinSwissprotsmall molecule
DB05219 CrisaboroleDrugbanksmall molecule
DB05541 BrivaracetamDrugbanksmall molecule
DB05812 AbirateroneDrugbanksmall molecule
DB06137 TirbanibulinDrugbanksmall molecule
DB06150 SulfadimethoxineSwissprotsmall molecule
DB06174 NoscapineDrugbanksmall molecule
DB06204 TapentadolDrugbanksmall molecule
DB06209 PrasugrelDrugbanksmall molecule
DB06218 LacosamideDrugbanksmall molecule
DB06268 SitaxentanDrugbanksmall molecule
DB06292 DapagliflozinDrugbanksmall molecule
DB06370 IndisulamSwissprotsmall molecule
DB06413 ArmodafinilDrugbanksmall molecule
DB06414 EtravirineDrugbanksmall molecule
DB06442 AvasimibeDrugbanksmall molecule
DB06448 LonafarnibDrugbanksmall molecule
DB06594 AgomelatineDrugbanksmall molecule
DB06595 MidostaurinDrugbanksmall molecule
DB06605 ApixabanDrugbanksmall molecule
DB06652 VicrivirocDrugbanksmall molecule
DB06654 SafinamideDrugbanksmall molecule
DB06697 ArtemetherSwissprotsmall molecule
DB06717 FosaprepitantSwissprotsmall molecule
DB06725 LornoxicamDrugbanksmall molecule
DB06729 SulfaphenazoleDrugbanksmall molecule
DB06731 SeproxetineSwissprotsmall molecule
DB06736 AceclofenacDrugbanksmall molecule
DB06737 ZaltoprofenSwissprotsmall molecule
DB06738 KetobemidoneDrugbanksmall molecule
DB06739 SeratrodastDrugbanksmall molecule
DB06803 NiclosamideSwissprotsmall molecule
DB06820 SulconazoleSwissprotsmall molecule
DB07615 TranilastDrugbanksmall molecule
DB08439 ParecoxibDrugbanksmall molecule
DB08496 (R)-warfarinSwissprotsmall molecule
DB08502 CapravirineDrugbanksmall molecule
DB08798 SulfamoxoleDrugbanksmall molecule
DB08816 TicagrelorDrugbanksmall molecule
DB08828 VismodegibDrugbanksmall molecule
DB08860 PitavastatinDrugbanksmall molecule
DB08875 CabozantinibDrugbanksmall molecule
DB08881 VemurafenibDrugbanksmall molecule
DB08896 RegorafenibDrugbanksmall molecule
DB08899 EnzalutamideDrugbanksmall molecule
DB08912 DabrafenibDrugbanksmall molecule
DB08962 GlibornurideSwissprotsmall molecule
DB09048 NetupitantDrugbanksmall molecule
DB09061 CannabidiolDrugbanksmall molecule
DB09063 CeritinibDrugbanksmall molecule
DB09068 VortioxetineDrugbanksmall molecule
DB09078 LenvatinibDrugbanksmall molecule
DB09080 OlodaterolDrugbanksmall molecule
DB09118 StiripentolDrugbanksmall molecule
DB09120 ZucapsaicinDrugbanksmall molecule
DB09167 DosulepinDrugbanksmall molecule
DB09198 LobeglitazoneDrugbanksmall molecule
DB09213 DexibuprofenDrugbanksmall molecule
DB09238 ManidipineDrugbanksmall molecule
DB09241 Methylene blueDrugbanksmall molecule
DB09280 LumacaftorDrugbanksmall molecule
DB09288 PropacetamolDrugbanksmall molecule
DB09570 IxazomibSwissprotsmall molecule
DB11560 LesinuradDrugbanksmall molecule
DB11586 AsunaprevirDrugbanksmall molecule
DB11611 LifitegrastDrugbanksmall molecule
DB11614 RupatadineDrugbanksmall molecule
DB11633 IsavuconazoleDrugbanksmall molecule
DB11672 CurcuminDrugbanksmall molecule
DB11689 SelumetinibDrugbanksmall molecule
DB11753 RifamycinDrugbanksmall molecule
DB11757 IstradefyllineDrugbanksmall molecule
DB11823 EsketamineDrugbanksmall molecule
DB11901 ApalutamideDrugbanksmall molecule
DB11943 DelafloxacinDrugbanksmall molecule
DB11963 DacomitinibDrugbanksmall molecule
DB11994 DiacereinDrugbanksmall molecule
DB11995 AvatrombopagDrugbanksmall molecule
DB12001 AbemaciclibDrugbanksmall molecule
DB12015 AlpelisibDrugbanksmall molecule
DB12070 LetermovirDrugbanksmall molecule
DB12147 ErdafitinibDrugbanksmall molecule
DB12245 TriclabendazoleDrugbanksmall molecule
DB12319 BenzbromaroneDrugbanksmall molecule
DB12332 RucaparibDrugbanksmall molecule
DB12371 SiponimodDrugbanksmall molecule
DB12457 RimegepantDrugbanksmall molecule
DB12474 LynestrenolSwissprotsmall molecule
DB12499 ClascoteroneDrugbanksmall molecule
DB12808 TrifaroteneDrugbanksmall molecule
DB12978 PexidartinibDrugbanksmall molecule
DB13136 FluindioneSwissprotsmall molecule
DB13174 RheinDrugbanksmall molecule
DB13406 CarbutamideSwissprotsmall molecule
DB13609 UmifenovirSwissprotsmall molecule
DB13675 MetahexamideSwissprotsmall molecule
DB13746 BioallethrinDrugbanksmall molecule
DB13874 EnasidenibDrugbanksmall molecule
DB13919 CandesartanDrugbanksmall molecule
DB13941 PiperaquineSwissprotsmall molecule
DB13943 Testosterone cypionateDrugbanksmall molecule
DB13944 Testosterone enanthateDrugbanksmall molecule
DB13946 Testosterone undecanoateDrugbanksmall molecule
DB13952 Estradiol acetateDrugbanksmall molecule
DB13953 Estradiol benzoateDrugbanksmall molecule
DB13954 Estradiol cypionateDrugbanksmall molecule
DB13955 Estradiol dienanthateDrugbanksmall molecule
DB13956 Estradiol valerateDrugbanksmall molecule
DB13975 Black cohoshSwissprotbiotech
DB14009 Medical CannabisDrugbankbiotech
DB14011 NabiximolsDrugbanksmall molecule
DB14025 ClinafloxacinSwissprotsmall molecule
DB14033 Acetyl sulfisoxazoleDrugbanksmall molecule
DB14055 (S)-WarfarinSwissprotsmall molecule
DB14568 IvosidenibDrugbanksmall molecule
DB14631 Prednisolone phosphateDrugbanksmall molecule
DB14635 Curcumin sulfateDrugbanksmall molecule
DB14881 OliceridineDrugbanksmall molecule
DB14975 VoxelotorDrugbanksmall molecule
DB15233 AvapritinibDrugbanksmall molecule
DB15328 UbrogepantDrugbanksmall molecule
DB15444 ElexacaftorDrugbanksmall molecule
DB15822 PralsetinibDrugbanksmall molecule