Entity Details

Primary name GRAA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP12544
EntryNameGRAA_HUMAN
FullNameGranzyme A
TaxID9606
Evidenceevidence at protein level
Length262
SequenceStatuscomplete
DateCreated1989-10-01
DateModified2021-06-02

Ontological Relatives

GenesGZMA

GO terms

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GOName
GO:0001772 immunological synapse
GO:0004252 serine-type endopeptidase activity
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0006915 apoptotic process
GO:0006955 immune response
GO:0009617 response to bacterium
GO:0019835 cytolysis
GO:0032078 negative regulation of endodeoxyribonuclease activity
GO:0042803 protein homodimerization activity
GO:0043065 positive regulation of apoptotic process
GO:0043392 negative regulation of DNA binding
GO:0051354 negative regulation of oxidoreductase activity
GO:0051603 proteolysis involved in cellular protein catabolic process
GO:0070269 pyroptosis
GO:0140507 granzyme-mediated programmed cell death signaling pathway
GO:1902483 cytotoxic T cell pyroptotic process

Subcellular Location

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Subcellular Location
Cytoplasmic granule
Secreted

Domains

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DomainNameCategoryType
IPR001254 Serine proteases, trypsin domainDomainDomain
IPR001314 Peptidase S1A, chymotrypsin familyFamilyFamily
IPR009003 Peptidase S1, PA clanFamilyHomologous superfamily
IPR018114 Serine proteases, trypsin family, histidine active siteSiteActive site
IPR033116 Serine proteases, trypsin family, serine active siteSiteActive site
IPR043504 Peptidase S1, PA clan, chymotrypsin-like foldFamilyHomologous superfamily

Diseases

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