Entity Details

Primary name BRAF_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP15056
EntryNameBRAF_HUMAN
FullNameSerine/threonine-protein kinase B-raf
TaxID9606
Evidenceevidence at protein level
Length766
SequenceStatuscomplete
DateCreated1990-11-01
DateModified2021-06-02

Ontological Relatives

GenesBRAF

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000186 obsolete activation of MAPKK activity
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005509 calcium ion binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0009887 animal organ morphogenesis
GO:0010628 positive regulation of gene expression
GO:0010828 positive regulation of glucose transmembrane transport
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0042802 identical protein binding
GO:0043066 negative regulation of apoptotic process
GO:0043231 intracellular membrane-bounded organelle
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070413 trehalose metabolism in response to stress
GO:0071277 cellular response to calcium ion
GO:0090150 establishment of protein localization to membrane
GO:0097110 scaffold protein binding
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domainDomainDomain
IPR003116 Raf-like Ras-bindingDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020454 Diacylglycerol/phorbol-ester bindingDomainDomain
IPR029071 Ubiquitin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00398 SorafenibDrugbanksmall molecule
DB05190 XL281Drugbanksmall molecule
DB05984 RAF-265Drugbanksmall molecule
DB06999 PLX-4720Drugbanksmall molecule
DB07000 N-{2,4-difluoro-3-[(5-pyridin-3-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]phenyl}ethanesulfonamideDrugbanksmall molecule
DB08553 (1E)-5-(1-piperidin-4-yl-3-pyridin-4-yl-1H-pyrazol-4-yl)-2,3-dihydro-1H-inden-1-one oximeDrugbanksmall molecule
DB08881 VemurafenibDrugbanksmall molecule
DB08896 RegorafenibDrugbanksmall molecule
DB08912 DabrafenibDrugbanksmall molecule
DB11718 EncorafenibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule
DB14840 RipretinibDrugbanksmall molecule

Interactions

73 interactions

InteractorPartnerSourcesPublicationsLink
BRAF_HUMAN1433B_HUMANBioGRID, HPRD, IntAct, MINT10931830 12620389 15324660 17353931 24255178 27034005 27684187 28514442 31980649 details
BRAF_HUMAN1433T_HUMANBioGRID, HPRD, IntAct, MINT15324660 17353931 17979178 18332145 27034005 27684187 28514442 31015455 31980649 8668348 details
BRAF_HUMAN1433G_HUMANBioGRID, HPRD, IntAct, MINT15324660 17353931 17979178 27034005 27684187 28205554 28514442 31980649 details
BRAF_HUMAN1433Z_HUMANBioGRID, HPRD, IntAct, MINT15161933 15324660 17353931 17979178 26496610 27034005 27684187 28205554 28514442 31980649 8668348 details
BRAF_HUMANTIM50_HUMANIntAct12620389 details
BRAF_HUMANMS18B_HUMANHPRD, IntAct12620389 details
BRAF_HUMANM3K1_HUMANMINT16810323 16888650 details
BRAF_HUMANBRAF_HUMANBioGRID, DIP, HPRD, IntAct, MINT16858395 17192257 1748651 17979178 19727074 22169110 22510884 25155755 25437913 28205554 31980649 7935374 details
BRAF_HUMAN1433S_HUMANBioGRID, IntAct, MINT15778465 27034005 27684187 28205554 31980649 details
BRAF_HUMANMP2K1_HUMANBioGRID, DIP, HPRD, IntAct16810323 16888650 17979178 18332145 19371126 20212043 23934108 24746704 25155755 25437913 25600339 26496610 27034005 27684187 28514442 31015455 31980649 7731720 8157000 8394352 8621729 9733801 details
BRAF_HUMAN1433F_HUMANBioGRID, HPRD, IntAct17979178 27034005 28514442 31980649 8668348 details
BRAF_HUMANARAF_HUMANBioGRID, DIP, IntAct17979178 20130576 25241761 28205554 28514442 31980649 details
BRAF_HUMANRAF1_HUMANBioGRID, DIP, HPRD, IntAct, MINT11325826 16803888 18332145 20130576 20141835 20212043 22169110 22510884 22605333 23153539 23680146 23934108 25155755 26466569 28514442 28806393 31015455 31980649 details
BRAF_HUMANTERF1_HUMANBioGRID, IntAct20936779 details
BRAF_HUMANPAK2_HUMANBioGRID, IntAct20936779 details
BRAF_HUMANGRDN_HUMANBioGRID, IntAct20936779 details
BRAF_HUMANAKT1_HUMANBioGRID, HPRD, IntAct10869359 11410590 25241761 28205554 details
BRAF_HUMANMK03_HUMANBioGRID, IntAct24412244 25241761 details
BRAF_HUMANCATL2_HUMANBioGRID, MINT24412244 details
BRAF_HUMANF16P1_HUMANBioGRID, MINT24412244 details
BRAF_HUMANDHB3_HUMANBioGRID, MINT24412244 details
BRAF_HUMANMAPK3_HUMANMINT24412244 details
BRAF_HUMANZN189_HUMANBioGRID, MINT24412244 details
BRAF_HUMANZN510_HUMANBioGRID, MINT24412244 details
BRAF_HUMANRASK_HUMANBioGRID, IntAct27034005 27684187 28205554 28514442 30194290 31980649 34079125 details
BRAF_HUMANRASH_HUMANBioGRID, DIP, HPRD, IntAct16803888 22605333 24441586 26165597 27034005 28205554 28514442 30194290 30639242 7706312 9154803 details
BRAF_HUMANIQGA1_HUMANBioGRID, DIP17563371 18567582 27034005 27684187 details
BRAF_HUMANRASN_HUMANBioGRID, DIP21478863 27034005 30194290 30639242 31015455 7499408 9368069 details
BRAF_HUMANKS6B2_HUMANBioGRID, MINT16810323 21625473 25324306 details
BRAF_HUMANRPGP1_HUMANBioGRID, HPRD10854065 11278445 details
BRAF_HUMANRAP1A_HUMANBioGRID, HPRD10454553 16507992 9560161 details
BRAF_HUMANNED4L_HUMANBioGRID19953087 31015455 details
BRAF_HUMANMK01_HUMANBioGRID, HPRD14654779 18567582 26285778 details
BRAF_HUMANBAD_HUMANBioGRID19667065 details
BRAF_HUMANMP2K7_HUMANBioGRID27034005 30082909 details
BRAF_HUMANSPY2_HUMANBioGRID19690147 details
BRAF_HUMANNANOG_HUMANBioGRID30595535 details
BRAF_HUMANITCH_HUMANBioGRID31015455 details
BRAF_HUMANPP2AA_HUMANBioGRID31015455 details
BRAF_HUMAN2ABA_HUMANBioGRID31015455 details
BRAF_HUMANAURKA_HUMANBioGRID28205554 details
BRAF_HUMANLATS2_HUMANBioGRID28205554 details
BRAF_HUMANMP2K3_HUMANBioGRID28205554 details
BRAF_HUMANMP2K6_HUMANBioGRID28205554 details
BRAF_HUMANRASF1_HUMANBioGRID28205554 details
BRAF_HUMANSTK11_HUMANBioGRID28205554 details
BRAF_HUMANTERT_HUMANBioGRID28205554 details
BRAF_HUMANPEBP1_HUMANBioGRID15886202 details
BRAF_HUMANCRBN_HUMANBioGRID32778845 details
BRAF_HUMANKPCA_HUMANMINT16810323 details
BRAF_HUMANKPCE_HUMANBioGRID, HPRD, MINT16810323 21625473 details
BRAF_HUMANKS6A2_HUMANMINT16810323 details
BRAF_HUMANMP2K2_HUMANBioGRID, HPRD, IntAct17979178 24746704 25600339 27034005 28514442 31980649 8668348 details
BRAF_HUMANHS90B_HUMANBioGRID, IntAct17979178 22939624 27684187 31980649 details
BRAF_HUMANKSR1_HUMANBioGRID, MINT18332145 22510884 details
BRAF_HUMANKSR2_HUMANMINT22510884 details
BRAF_HUMANTRAF3_HUMANIntAct23153539 details
BRAF_HUMANHS90A_HUMANBioGRID, IntAct22939624 27034005 27684187 28146421 31980649 details
BRAF_HUMANRASM_HUMANBioGRID, HPRD12138204 details
BRAF_HUMANRN149_HUMANBioGRID22628551 details
BRAF_HUMANBRAP_HUMANBioGRID18332145 details
BRAF_HUMANFBXW7_HUMANBioGRID26898828 details
BRAF_HUMANFNIP1_HUMANBioGRID27353360 details
BRAF_HUMANFNIP2_HUMANBioGRID27353360 details
BRAF_HUMANHSP74_HUMANBioGRID27034005 28146421 details
BRAF_HUMANTRAF2_HUMANBioGRID29748372 details
BRAF_HUMANSMUF2_HUMANBioGRID31015455 details
BRAF_HUMANWWP1_HUMANBioGRID31015455 details
BRAF_HUMANWWP2_HUMANBioGRID31015455 details
BRAF_HUMANTRAP1_HUMANBioGRID26084290 details
BRAF_HUMANRHEB_HUMANHPRD16803888 details
BRAF_HUMANKAPCA_HUMANHPRD11510412 details
BRAF_HUMANSGK1_HUMANHPRD10869359 11410590 details