Entity Details

Primary name RAC2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP15153
EntryNameRAC2_HUMAN
FullNameRas-related C3 botulinum toxin substrate 2
TaxID9606
Evidenceevidence at protein level
Length192
SequenceStatuscomplete
DateCreated1990-04-01
DateModified2021-06-02

Ontological Relatives

GenesRAC2

GO terms

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GOName
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0005635 nuclear envelope
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0005938 cell cortex
GO:0007015 actin filament organization
GO:0007163 establishment or maintenance of cell polarity
GO:0007165 signal transduction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0008045 motor neuron axon guidance
GO:0008284 positive regulation of cell population proliferation
GO:0008360 regulation of cell shape
GO:0010310 regulation of hydrogen peroxide metabolic process
GO:0010592 positive regulation of lamellipodium assembly
GO:0010810 regulation of cell-substrate adhesion
GO:0016601 Rac protein signal transduction
GO:0019887 protein kinase regulator activity
GO:0019901 protein kinase binding
GO:0030027 lamellipodium
GO:0030031 cell projection assembly
GO:0030670 phagocytic vesicle membrane
GO:0030865 cortical cytoskeleton organization
GO:0031410 cytoplasmic vesicle
GO:0032956 regulation of actin cytoskeleton organization
GO:0042129 regulation of T cell proliferation
GO:0042995 cell projection
GO:0043231 intracellular membrane-bounded organelle
GO:0043304 regulation of mast cell degranulation
GO:0043652 engulfment of apoptotic cell
GO:0045453 bone resorption
GO:0045454 cell redox homeostasis
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051897 positive regulation of protein kinase B signaling
GO:0060263 regulation of respiratory burst
GO:0060753 regulation of mast cell chemotaxis
GO:0070062 extracellular exosome
GO:0071593 lymphocyte aggregation
GO:0090023 positive regulation of neutrophil chemotaxis
GO:1902622 regulation of neutrophil migration
GO:1903955 positive regulation of protein targeting to mitochondrion

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR001806 Small GTPaseFamilyFamily
IPR003578 Small GTPase RhoFamilyFamily
IPR005225 Small GTP-binding protein domainDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00514 DextromethorphanDrugbanksmall molecule

Interactions

31 interactions

InteractorPartnerSourcesPublicationsLink
RAC2_HUMANGDIR2_HUMANBioGRID, HPRD, MINT10655614 details
RAC2_HUMANNCF2_HUMANBioGRID, HPRD, MINT11090627 9624165 9642115 details
RAC2_HUMANADA22_HUMANBioGRID, IntAct21988832 details
RAC2_HUMANAFG32_HUMANBioGRID, MINT21900206 details
RAC2_HUMANSCG1_HUMANBioGRID, MINT21900206 details
RAC2_HUMANXIAP_HUMANMINT22117219 details
RAC2_HUMANHDAC7_HUMANBioGRID, IntAct32296183 details
RAC2_HUMANARFP2_HUMANBioGRID, HPRD, IntAct11346801 32296183 details
RAC2_HUMANPLD2_HUMANDIP22106281 details
RAC2_HUMANDOCK2_HUMANBioGRID, DIP, HPRD10559471 14737186 details
RAC2_HUMANCUL1_HUMANBioGRID, HPRD11445862 details
RAC2_HUMANDEFI6_HUMANBioGRID, HPRD15023524 details
RAC2_HUMANACTB_HUMANBioGRID, HPRD11027608 details
RAC2_HUMANICMT_HUMANBioGRID, HPRD9614111 details
RAC2_HUMANNOS2_HUMANBioGRID, HPRD11457725 details
RAC2_HUMANPAK2_HUMANBioGRID12176041 details
RAC2_HUMANGDIR1_HUMANBioGRID, HPRD11368848 11513578 9490022 details
RAC2_HUMANAGAP2_HUMANBioGRID22453919 details
RAC2_HUMANNOXA1_HUMANHPRD12716910 details
RAC2_HUMANCY24B_HUMANInnateDB22366891 details
RAC2_HUMANWASP_HUMANmbinfo14521508 details
RAC2_HUMANPAK1_HUMANmbinfo14521508 details
RAC2_HUMANRAC2_HUMANmbinfo9748241 details
RAC2_HUMANTP8L2_HUMANDIP22949657 details
RAC2_HUMANITA4_HUMANBioGRID22623428 details
RAC2_HUMANU2AF2_HUMANBioGRID26641092 details
RAC2_HUMANGDIA_HUMANHPRD9490022 details
RAC2_HUMANCDC42_HUMANHPRD9748241 details
RAC2_HUMANSMAD1_HUMANHPRD15761153 details
RAC2_HUMANSMAD4_HUMANHPRD15761153 details
RAC2_HUMANRTKN_HUMANHPRD12516569 details