Entity Details

Primary name EZRI_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP15311
EntryNameEZRI_HUMAN
FullNameEzrin
TaxID9606
Evidenceevidence at protein level
Length586
SequenceStatuscomplete
DateCreated1990-04-01
DateModified2021-06-02

Ontological Relatives

GenesEZR

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001650 fibrillar center
GO:0001726 ruffle
GO:0001772 immunological synapse
GO:0001931 uropod
GO:0001951 intestinal D-glucose absorption
GO:0003376 sphingosine-1-phosphate receptor signaling pathway
GO:0003723 RNA binding
GO:0003779 actin binding
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005829 cytosol
GO:0005884 actin filament
GO:0005886 plasma membrane
GO:0005902 microvillus
GO:0005903 brush border
GO:0005925 focal adhesion
GO:0007159 leukocyte cell-cell adhesion
GO:0007411 axon guidance
GO:0008017 microtubule binding
GO:0008022 protein C-terminus binding
GO:0008360 regulation of cell shape
GO:0010628 positive regulation of gene expression
GO:0010737 protein kinase A signaling
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0019898 extrinsic component of membrane
GO:0019904 protein domain specific binding
GO:0022614 membrane to membrane docking
GO:0030033 microvillus assembly
GO:0030175 filopodium
GO:0030315 T-tubule
GO:0030863 cortical cytoskeleton
GO:0030953 astral microtubule organization
GO:0031528 microvillus membrane
GO:0031532 actin cytoskeleton reorganization
GO:0031623 receptor internalization
GO:0031982 vesicle
GO:0032532 regulation of microvillus length
GO:0032587 ruffle membrane
GO:0032703 negative regulation of interleukin-2 production
GO:0032991 protein-containing complex
GO:0034236 protein kinase A catalytic subunit binding
GO:0034237 protein kinase A regulatory subunit binding
GO:0034629 cellular protein-containing complex localization
GO:0035088 establishment or maintenance of apical/basal cell polarity
GO:0036064 ciliary basal body
GO:0040018 positive regulation of multicellular organism growth
GO:0042802 identical protein binding
GO:0042995 cell projection
GO:0043622 cortical microtubule organization
GO:0044297 cell body
GO:0044393 microspike
GO:0044548 S100 protein binding
GO:0044853 plasma membrane raft
GO:0045177 apical part of cell
GO:0045296 cadherin binding
GO:0046847 filopodium assembly
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048471 perinuclear region of cytoplasm
GO:0050714 positive regulation of protein secretion
GO:0050839 cell adhesion molecule binding
GO:0050860 negative regulation of T cell receptor signaling pathway
GO:0051015 actin filament binding
GO:0051017 actin filament bundle assembly
GO:0051018 protein kinase A binding
GO:0051117 ATPase binding
GO:0051286 cell tip
GO:0051660 establishment of centrosome localization
GO:0061028 establishment of endothelial barrier
GO:0070062 extracellular exosome
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0071320 cellular response to cAMP
GO:0071944 cell periphery
GO:0072659 protein localization to plasma membrane
GO:0072697 protein localization to cell cortex
GO:0097449 astrocyte projection
GO:0097454 Schwann cell microvillus
GO:0097718 disordered domain specific binding
GO:0098592 cytoplasmic side of apical plasma membrane
GO:1902115 regulation of organelle assembly
GO:1902896 terminal web assembly
GO:1902966 positive regulation of protein localization to early endosome
GO:1903078 positive regulation of protein localization to plasma membrane
GO:1903364 positive regulation of cellular protein catabolic process
GO:1903753 negative regulation of p38MAPK cascade
GO:2000643 positive regulation of early endosome to late endosome transport

Subcellular Location

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Subcellular Location
Apical cell membrane
Cell projection
Cytoplasm

Domains

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DomainNameCategoryType
IPR000299 FERM domainDomainDomain
IPR000798 Ezrin/radixin/moesin-likeFamilyFamily
IPR008954 Moesin tail domain superfamilyFamilyHomologous superfamily
IPR011174 Ezrin/radixin/moesinFamilyFamily
IPR011259 Ezrin/radixin/moesin, C-terminalDomainDomain
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR014352 FERM/acyl-CoA-binding protein superfamilyFamilyHomologous superfamily
IPR018979 FERM, N-terminalDomainDomain
IPR018980 FERM, C-terminal PH-like domainDomainDomain
IPR019747 FERM conserved siteSiteConserved site
IPR019748 FERM central domainDomainDomain
IPR019749 Band 4.1 domainDomainDomain
IPR029071 Ubiquitin-like domain superfamilyFamilyHomologous superfamily
IPR035963 FERM superfamily, second domainFamilyHomologous superfamily
IPR041789 ERM family, FERM domain C-lobeDomainDomain

Diseases

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Interactions

97 interactions

InteractorPartnerSourcesPublicationsLink
EZRI_HUMANNHRF1_HUMANBioGRID, HPRD, IntAct, MINT11285285 11684085 15020681 20937695 23414517 26344197 29568061 34079125 9314537 details
EZRI_HUMANEZRI_HUMANBioGRID, HPRD, IntAct, MINT, UniProt11285285 21988832 29568061 31837246 9501018 details
EZRI_HUMANPACE1_HUMANBioGRID, HPRD, IntAct12651155 34079125 details
EZRI_HUMANFES_HUMANMINT18046454 details
EZRI_HUMANMDM2_HUMANBioGRID, IntAct20195357 details
EZRI_HUMANP85A_HUMANBioGRID, HPRD, MINT10377409 details
EZRI_HUMANMPP3_HUMANBioGRID, IntAct21988832 details
EZRI_HUMANWFDC1_HUMANBioGRID, IntAct21988832 details
EZRI_HUMANRADI_HUMANBioGRID, HPRD, IntAct22939629 23414517 26496610 29568061 34079125 9501018 details
EZRI_HUMANNHRF2_HUMANBioGRID, HPRD, IntAct12080047 23414517 9748260 details
EZRI_HUMANUBP1_HUMANBioGRID, IntAct23414517 details
EZRI_HUMANCD44_HUMANBioGRID, HPRD, IntAct12032545 12370738 20711218 details
EZRI_HUMANCAN1_HUMANMINT22805611 details
EZRI_HUMANHD_HUMANIntAct17500595 32814053 details
EZRI_HUMANEGFR_HUMANBioGRID, HPRD, IntAct12560083 1382070 24658140 31980649 details
EZRI_HUMANERBB2_HUMANBioGRID, IntAct24658140 27029001 details
EZRI_HUMANMOES_HUMANBioGRID, HPRD, IntAct15659383 26496610 29568061 34079125 7579708 8248180 details
EZRI_HUMANMISP_HUMANBioGRID, IntAct28514442 32296183 details
EZRI_HUMANDLG1_HUMANBioGRID, HPRD, IntAct11726633 29568061 34079125 details
EZRI_HUMANERBB3_HUMANBioGRID, IntAct31980649 details
EZRI_HUMANS10A2_HUMANUniProt31837246 details
EZRI_HUMANS10A4_HUMANUniProt31837246 details
EZRI_HUMANCB015_HUMANIntAct32814053 details
EZRI_HUMANTHAP3_HUMANIntAct32814053 details
EZRI_HUMANMIER1_HUMANIntAct32814053 details
EZRI_HUMANBECN1_HUMANIntAct32814053 details
EZRI_HUMANS100P_HUMANBioGRID, HPRD12808036 details
EZRI_HUMANMERL_HUMANBioGRID, HPRD10036239 17891137 details
EZRI_HUMANFAK1_HUMANBioGRID11468295 details
EZRI_HUMANL1CAM_HUMANBioGRID, HPRD12070130 22846990 details
EZRI_HUMANICAM1_HUMANBioGRID, HPRD9705328 details
EZRI_HUMANICAM2_HUMANBioGRID, HPRD9705328 details
EZRI_HUMANICAM3_HUMANBioGRID, HPRD11784723 9705328 details
EZRI_HUMANVCAM1_HUMANBioGRID, HPRD12082081 details
EZRI_HUMANIQGA1_HUMANBioGRID10793131 details
EZRI_HUMANCLIC5_HUMANBioGRID, HPRD10793131 details
EZRI_HUMANPALLD_HUMANBioGRID, HPRD1159819 11598191 details
EZRI_HUMANLYAM3_HUMANBioGRID, HPRD10733515 details
EZRI_HUMANLYAM1_HUMANBioGRID, HPRD11706008 details
EZRI_HUMANSDC2_HUMANBioGRID, HPRD10704377 details
EZRI_HUMANLEUK_HUMANBioGRID, HPRD9616160 details
EZRI_HUMANGRAM_HUMANBioGRID18523284 details
EZRI_HUMANVPS11_HUMANBioGRID21148287 details
EZRI_HUMANNEP_HUMANBioGRID20957047 details
EZRI_HUMANSUMO2_HUMANBioGRID32786267 details
EZRI_HUMANADA1B_HUMANHPRD16352594 details
EZRI_HUMANCAN6_HUMANMINT11285285 details
EZRI_HUMANPLCB3_HUMANMINT11285285 details
EZRI_HUMANTB10A_HUMANHPRD, IntAct, MINT11285285 20937695 details
EZRI_HUMANVHL_HUMANIntAct17353931 details
EZRI_HUMANCNOT8_HUMANIntAct17353931 details
EZRI_HUMANPINX1_HUMANIntAct17353931 details
EZRI_HUMANRIPK2_HUMANIntAct17353931 details
EZRI_HUMANIKKE_HUMANIntAct17353931 details
EZRI_HUMANTRAF6_HUMANIntAct17353931 details
EZRI_HUMANSGK1_HUMANIntAct17353931 details
EZRI_HUMAN1433Z_HUMANMINT15161933 details
EZRI_HUMANGDIR1_HUMANBioGRID, IntAct15659383 20711218 26344197 details
EZRI_HUMANFADD_HUMANBioGRID, IntAct15659383 21183682 25241761 details
EZRI_HUMANS12A2_HUMANBioGRID, DIP, Molecular Connections22570591 24555568 34079125 details
EZRI_HUMANPTPRQ_HUMANIntActunassigned1312 details
EZRI_HUMANAHNK_HUMANBioGRID, IntAct14625392 29568061 details
EZRI_HUMANCFTR_HUMANBioGRID, HPRD, IntAct10893422 26618866 29924966 details
EZRI_HUMANNEDD4_HUMANBioGRID, MINT24981860 30385740 details
EZRI_HUMANBID_HUMANBioGRID15659383 details
EZRI_HUMANTR10B_HUMANBioGRID15659383 details
EZRI_HUMANTNR6_HUMANBioGRID, HPRD14676203 15659383 17159908 details
EZRI_HUMANRHOA_HUMANBioGRID15659383 details
EZRI_HUMANTNFL6_HUMANBioGRID, HPRD11013215 15659383 details
EZRI_HUMANMK08_HUMANBioGRID15659383 details
EZRI_HUMANCASPA_HUMANBioGRID15659383 details
EZRI_HUMANCASP8_HUMANBioGRID15659383 details
EZRI_HUMANTNR1A_HUMANBioGRID15659383 details
EZRI_HUMANPEPL_HUMANBioGRID14625392 details
EZRI_HUMANSPTA1_HUMANBioGRID14625392 details
EZRI_HUMANPRAX_HUMANBioGRID14625392 details
EZRI_HUMANTSC1_HUMANBioGRID, HPRD10806479 details
EZRI_HUMANAA2BR_HUMANBioGRID, HPRD12080047 details
EZRI_HUMANKPCA_HUMANBioGRID, HPRD10970850 11387207 details
EZRI_HUMANCTNB1_HUMANBioGRID, HPRD10462524 details
EZRI_HUMANCADH1_HUMANBioGRID10462524 25468996 details
EZRI_HUMANWWP1_HUMANBioGRID22629406 details
EZRI_HUMANBRCA1_HUMANBioGRID21282464 26831064 details
EZRI_HUMANU2AF2_HUMANBioGRID26641092 details
EZRI_HUMANSOCS2_HUMANBioGRID28883622 details
EZRI_HUMANACTC_HUMANBioGRID, HPRD12271120 30890647 details
EZRI_HUMANPODXL_HUMANBioGRID30385740 details
EZRI_HUMANACTB_HUMANBioGRID, HPRD34079125 7876308 details
EZRI_HUMANCDK5_HUMANHPRD12769842 details
EZRI_HUMANWWOX_HUMANHPRD16438931 details
EZRI_HUMANPTPRC_HUMANHPRD12560083 details
EZRI_HUMANLCK_HUMANHPRD12560083 1382070 details
EZRI_HUMANKAP2_HUMANHPRD12080047 details
EZRI_HUMANROCK1_HUMANHPRD10970850 11387207 details
EZRI_HUMANGDIR2_HUMANHPRD9287351 details
EZRI_HUMANTMM8B_HUMANHPRD15498789 details
EZRI_HUMANARF6_HUMANHPRD16737952 details