Entity Details

Primary name AREG_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP15514
EntryNameAREG_HUMAN
FullNameAmphiregulin
TaxID9606
Evidenceevidence at protein level
Length252
SequenceStatuscomplete
DateCreated1990-04-01
DateModified2021-06-02

Ontological Relatives

GenesAREG

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0005125 cytokine activity
GO:0005154 epidermal growth factor receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005789 endoplasmic reticulum membrane
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0008083 growth factor activity
GO:0008284 positive regulation of cell population proliferation
GO:0009986 cell surface
GO:0010838 positive regulation of keratinocyte proliferation
GO:0012507 ER to Golgi transport vesicle membrane
GO:0016021 integral component of membrane
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0045741 positive regulation of epidermal growth factor-activated receptor activity
GO:0048208 COPII vesicle coating
GO:0051897 positive regulation of protein kinase B signaling
GO:0061024 membrane organization

Subcellular Location

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Subcellular Location
Membrane

Domains

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DomainNameCategoryType
IPR000742 EGF-like domainDomainDomain
IPR015497 Epidermal growth factor receptor ligandFamilyFamily

Diseases

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