Entity Details

Primary name NCK1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP16333
EntryNameNCK1_HUMAN
FullNameCytoplasmic protein NCK1
TaxID9606
Evidenceevidence at protein level
Length377
SequenceStatuscomplete
DateCreated1990-08-01
DateModified2021-06-02

Ontological Relatives

GenesNCK1

GO terms

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GOName
GO:0000164 protein phosphatase type 1 complex
GO:0004860 protein kinase inhibitor activity
GO:0005102 signaling receptor binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0006930 substrate-dependent cell migration, cell extension
GO:0007015 actin filament organization
GO:0007172 signal complex assembly
GO:0008093 cytoskeletal anchor activity
GO:0010976 positive regulation of neuron projection development
GO:0012506 vesicle membrane
GO:0019904 protein domain specific binding
GO:0030032 lamellipodium assembly
GO:0030159 signaling receptor complex adaptor activity
GO:0030334 regulation of cell migration
GO:0030674 protein-macromolecule adaptor activity
GO:0030838 positive regulation of actin filament polymerization
GO:0030971 receptor tyrosine kinase binding
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0035591 signaling adaptor activity
GO:0036493 positive regulation of translation in response to endoplasmic reticulum stress
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042102 positive regulation of T cell proliferation
GO:0042110 T cell activation
GO:0045296 cadherin binding
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0046875 ephrin receptor binding
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048013 ephrin receptor signaling pathway
GO:0050852 T cell receptor signaling pathway
GO:0051707 response to other organism
GO:0060548 negative regulation of cell death
GO:0070262 peptidyl-serine dephosphorylation
GO:0071074 eukaryotic initiation factor eIF2 binding
GO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1903676 positive regulation of cap-dependent translational initiation
GO:1903679 positive regulation of cap-independent translational initiation
GO:1903898 negative regulation of PERK-mediated unfolded protein response
GO:1903912 negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
GO:1990441 negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

Subcellular Location

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Subcellular Location
Cytoplasm
Endoplasmic reticulum
Nucleus

Domains

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DomainNameCategoryType
IPR000980 SH2 domainDomainDomain
IPR001452 SH3 domainDomainDomain
IPR017304 Cytoplasmic protein NCKFamilyFamily
IPR028526 Cytoplasmic protein NCK1FamilyFamily
IPR035562 Nck1, SH3 domain 1DomainDomain
IPR035564 Nck1, SH3 domain 2DomainDomain
IPR035565 Nck1, SH3 domain 3DomainDomain
IPR035882 Nck1, SH2 domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

259 interactions

InteractorPartnerSourcesPublicationsLink
NCK1_HUMANWASP_HUMANBioGRID, HPRD, MINT10747096 11340081 12135674 24287595 7565724 details
NCK1_HUMANEGFR_HUMANBioGRID, HPRD, IntAct, MINT10026169 1333047 16273093 24658140 25402006 31980649 8662998 9362449 details
NCK1_HUMANCBL_HUMANBioGRID, HPRD, MINT10204582 10372803 10829062 10967110 11494134 16503409 24287595 7517397 9851874 details
NCK1_HUMANABI1_HUMANBioGRID, HPRD, UniProt11418237 11557983 details
NCK1_HUMANSYNJ1_HUMANMINT16137687 details
NCK1_HUMANACK1_HUMANBioGRID, HPRD, IntAct, MINT11278436 16137687 21309750 26496610 details
NCK1_HUMANERBB3_HUMANBioGRID, MINT16273093 22973453 details
NCK1_HUMANWIPF1_HUMANBioGRID, HPRD, IntAct12620186 26496610 9694849 details
NCK1_HUMANSOS1_HUMANBioGRID, HPRD, IntAct10026169 10206341 17474147 32203420 7862111 8810325 details
NCK1_HUMANDYN1_HUMANBioGRID, HPRD, IntAct10206341 11557983 details
NCK1_HUMANPAK2_HUMANBioGRID, HPRD, IntAct, MINT11160719 16374509 32296183 details
NCK1_HUMANADA15_HUMANBioGRID, HPRD, MINT16374509 18296648 details
NCK1_HUMANICAL_HUMANIntAct17474147 details
NCK1_HUMANSHAN3_HUMANIntAct17474147 21988832 details
NCK1_HUMANDLX4_HUMANIntAct17474147 details
NCK1_HUMANSOS2_HUMANIntAct17474147 details
NCK1_HUMANBRPF3_HUMANIntAct17474147 details
NCK1_HUMANSYNJ2_HUMANHPRD, IntAct10805734 17474147 details
NCK1_HUMANCDC27_HUMANIntAct17474147 details
NCK1_HUMANDAB2_HUMANIntAct17474147 details
NCK1_HUMANNELFB_HUMANIntAct17474147 details
NCK1_HUMANPTN4_HUMANIntAct17474147 details
NCK1_HUMANSNX17_HUMANIntAct17474147 details
NCK1_HUMANVP13A_HUMANIntAct17474147 details
NCK1_HUMANMINT_HUMANIntAct17474147 details
NCK1_HUMANELK3_HUMANIntAct17474147 details
NCK1_HUMANJAK2_HUMANIntAct17474147 details
NCK1_HUMANDUS15_HUMANIntAct17474147 details
NCK1_HUMANASXL1_HUMANIntAct17474147 details
NCK1_HUMANGHR_HUMANBioGRID, IntAct17474147 25241761 details
NCK1_HUMANMEPE_HUMANIntAct17474147 details
NCK1_HUMANDOCK3_HUMANIntAct17474147 details
NCK1_HUMANABL2_HUMANBioGRID, IntAct17474147 25241761 details
NCK1_HUMANBRCA1_HUMANIntAct17474147 details
NCK1_HUMANRL13_HUMANIntAct17474147 details
NCK1_HUMANPDIA2_HUMANIntAct17474147 details
NCK1_HUMANFOXH1_HUMANIntAct17474147 details
NCK1_HUMANFLNB_HUMANIntAct17474147 details
NCK1_HUMANH14_HUMANIntAct17474147 details
NCK1_HUMANTRAIP_HUMANIntAct17474147 details
NCK1_HUMANS23A1_HUMANIntAct17474147 details
NCK1_HUMANBRD4_HUMANIntAct17474147 details
NCK1_HUMANASAP2_HUMANIntAct17474147 details
NCK1_HUMANFYB1_HUMANIntAct17474147 22074159 details
NCK1_HUMANECT2_HUMANIntAct17474147 details
NCK1_HUMANSNX7_HUMANIntAct17474147 details
NCK1_HUMANAIRE_HUMANIntAct17474147 details
NCK1_HUMANNCKX1_HUMANIntAct17474147 details
NCK1_HUMANCELR2_HUMANIntAct17474147 details
NCK1_HUMANSHAN2_HUMANIntAct17474147 details
NCK1_HUMANRAG1_HUMANIntAct17474147 details
NCK1_HUMANI20L2_HUMANIntAct17474147 details
NCK1_HUMANDTBP1_HUMANIntAct17474147 details
NCK1_HUMANSUV92_HUMANIntAct17474147 details
NCK1_HUMANSASH1_HUMANIntAct17474147 details
NCK1_HUMANRPGF1_HUMANIntAct17474147 details
NCK1_HUMANCKAP5_HUMANIntAct17474147 details
NCK1_HUMANLRRC3_HUMANIntAct17474147 details
NCK1_HUMANP3C2B_HUMANIntAct17474147 details
NCK1_HUMANTRYB1_HUMANIntAct17474147 details
NCK1_HUMANCAF1A_HUMANIntAct17474147 details
NCK1_HUMANTRYB2_HUMANIntAct17474147 details
NCK1_HUMANKI13A_HUMANIntAct17474147 details
NCK1_HUMANABCG5_HUMANIntAct17474147 details
NCK1_HUMANCSDE1_HUMANIntAct17474147 details
NCK1_HUMANID4_HUMANIntAct17474147 details
NCK1_HUMANARHGB_HUMANIntAct17474147 details
NCK1_HUMANAKAP2_HUMANIntAct17474147 details
NCK1_HUMANTGDS_HUMANIntAct17474147 details
NCK1_HUMANPERE_HUMANIntAct17474147 details
NCK1_HUMANRRAS_HUMANBioGRID, HPRD, IntAct10671570 17474147 details
NCK1_HUMANMAP4_HUMANIntAct17474147 details
NCK1_HUMANTPX2_HUMANIntAct17474147 details
NCK1_HUMANASAP1_HUMANIntAct, MINT16636290 17474147 details
NCK1_HUMANTGON2_HUMANIntAct17474147 details
NCK1_HUMANSNX12_HUMANIntAct17474147 details
NCK1_HUMANPK3CD_HUMANIntAct17474147 details
NCK1_HUMANDLGP2_HUMANIntAct17474147 details
NCK1_HUMANDLGP4_HUMANBioGRID, IntAct17474147 32296183 details
NCK1_HUMANFCG2B_HUMANIntAct17474147 details
NCK1_HUMANFCG2C_HUMANIntAct17474147 details
NCK1_HUMANGABR1_HUMANIntAct17474147 details
NCK1_HUMANBAZ2A_HUMANIntAct17474147 details
NCK1_HUMANDAG1_HUMANBioGRID, IntAct11724572 17474147 details
NCK1_HUMANGNS_HUMANIntAct17474147 details
NCK1_HUMANSNX8_HUMANIntAct17474147 details
NCK1_HUMANDLGP1_HUMANIntAct17474147 details
NCK1_HUMANDLGP3_HUMANIntAct17474147 details
NCK1_HUMANSREC2_HUMANIntAct17474147 details
NCK1_HUMANMAAI_HUMANIntAct17474147 details
NCK1_HUMANSELN_HUMANIntAct17474147 details
NCK1_HUMANM4K1_HUMANBioGRID, HPRD, IntAct, MINT11279207 17474147 22974441 9346925 9891069 details
NCK1_HUMANF110A_HUMANIntAct17474147 details
NCK1_HUMANRIMS2_HUMANIntAct17474147 details
NCK1_HUMANABL1_HUMANBioGRID, HPRD, IntAct10372803 10967110 11494134 12379115 17474147 7926767 details
NCK1_HUMANEPS15_HUMANIntAct17474147 details
NCK1_HUMANSP1_HUMANIntAct17474147 details
NCK1_HUMANHNRPR_HUMANIntAct17474147 details
NCK1_HUMANPHAR2_HUMANIntAct17474147 details
NCK1_HUMANNKX21_HUMANIntAct17474147 details
NCK1_HUMANLAP2B_HUMANIntAct17474147 details
NCK1_HUMANCP4F2_HUMANIntAct17474147 details
NCK1_HUMANCNTP1_HUMANIntAct17474147 details
NCK1_HUMANBICRA_HUMANIntAct17474147 details
NCK1_HUMANAT2A3_HUMANIntAct17474147 details
NCK1_HUMANPAR3_HUMANIntAct17474147 details
NCK1_HUMANPRAX_HUMANIntAct17474147 details
NCK1_HUMANCELR3_HUMANIntAct17474147 details
NCK1_HUMANPNMA2_HUMANIntAct17474147 details
NCK1_HUMANRIMS1_HUMANIntAct17474147 details
NCK1_HUMANTULP1_HUMANIntAct17474147 details
NCK1_HUMANRAGE_HUMANIntAct17474147 details
NCK1_HUMANRPP38_HUMANIntAct17474147 details
NCK1_HUMANMYLK_HUMANIntAct17474147 details
NCK1_HUMANDCE1_HUMANIntAct17474147 details
NCK1_HUMANASB16_HUMANIntAct17474147 details
NCK1_HUMANNEK8_HUMANIntAct17474147 details
NCK1_HUMANRIN3_HUMANIntAct17474147 details
NCK1_HUMANKIFC2_HUMANIntAct17474147 details
NCK1_HUMANTRI39_HUMANIntAct17474147 details
NCK1_HUMANSEM7A_HUMANIntAct17474147 details
NCK1_HUMANCO6_HUMANIntAct17474147 details
NCK1_HUMANKMT2B_HUMANIntAct17474147 details
NCK1_HUMANCSMD2_HUMANIntAct17474147 details
NCK1_HUMANM4K5_HUMANIntAct17474147 details
NCK1_HUMANSHRM2_HUMANIntAct17474147 details
NCK1_HUMANSNX3_HUMANIntAct17474147 details
NCK1_HUMANGPR45_HUMANIntAct17474147 details
NCK1_HUMANEFS_HUMANBioGRID, IntAct17474147 26871637 details
NCK1_HUMANM4K3_HUMANIntAct17474147 details
NCK1_HUMANNCKP5_HUMANHPRD, IntAct17474147 9344857 details
NCK1_HUMANHXC8_HUMANIntAct17474147 details
NCK1_HUMANNPA1P_HUMANIntAct17474147 details
NCK1_HUMANPAX7_HUMANIntAct17474147 details
NCK1_HUMANIL3RA_HUMANIntAct17474147 details
NCK1_HUMANFLNC_HUMANIntAct17474147 details
NCK1_HUMANNFASC_HUMANIntAct17474147 details
NCK1_HUMANCHRD_HUMANIntAct17474147 details
NCK1_HUMANRP1L1_HUMANIntAct17474147 details
NCK1_HUMANAKAP6_HUMANIntAct17474147 details
NCK1_HUMANPRIC3_HUMANIntAct17474147 details
NCK1_HUMANCCR10_HUMANIntAct17474147 details
NCK1_HUMANACAP1_HUMANIntAct17474147 details
NCK1_HUMANGASR_HUMANIntAct17474147 details
NCK1_HUMANWASL_HUMANBioGRID, DIP, HPRD, IntAct11340081 16595635 17474147 26496610 26871637 details
NCK1_HUMANTLR9_HUMANIntAct17474147 details
NCK1_HUMANFANCA_HUMANIntAct17474147 details
NCK1_HUMANTNIK_HUMANHPRD, IntAct10521462 17474147 details
NCK1_HUMANANK2_HUMANIntAct17474147 details
NCK1_HUMANEHMT2_HUMANIntAct17474147 details
NCK1_HUMANCNTFR_HUMANIntAct17474147 details
NCK1_HUMANAFF2_HUMANIntAct17474147 details
NCK1_HUMANSF3B4_HUMANIntAct17474147 details
NCK1_HUMANRNC_HUMANBioGRID, IntAct17474147 26496610 details
NCK1_HUMANNXPH3_HUMANIntAct17474147 details
NCK1_HUMANNEU1_HUMANIntAct17474147 details
NCK1_HUMANSTF1_HUMANIntAct17474147 details
NCK1_HUMANMED14_HUMANIntAct17474147 details
NCK1_HUMANRPA2_HUMANIntAct17474147 details
NCK1_HUMANMYRIP_HUMANIntAct17474147 details
NCK1_HUMANP2RX7_HUMANIntAct17474147 details
NCK1_HUMANRYR1_HUMANIntAct17474147 details
NCK1_HUMANAPOL5_HUMANIntAct17474147 details
NCK1_HUMANPAX3_HUMANIntAct17474147 details
NCK1_HUMANNOTC3_HUMANIntAct17474147 details
NCK1_HUMANNPVF_HUMANIntAct17474147 details
NCK1_HUMANDOCK1_HUMANIntAct17474147 details
NCK1_HUMANS22A3_HUMANIntAct17474147 details
NCK1_HUMANCD3E_HUMANBioGRID, HPRD, MINT12110186 17617578 18955169 details
NCK1_HUMANTNFL6_HUMANBioGRID, DIP, HPRD, IntAct11741599 16595635 19807924 26871637 details
NCK1_HUMANLCP2_HUMANBioGRID, HPRD, IntAct, MINT10229072 15388330 15929943 20562827 21725281 22267732 31467278 details
NCK1_HUMANEPHB1_HUMANBioGRID, HPRD, MINT9430661 details
NCK1_HUMANPHC2_HUMANBioGRID, IntAct21988832 details
NCK1_HUMANAGRL2_HUMANBioGRID, IntAct21988832 details
NCK1_HUMANK1522_HUMANBioGRID, IntAct21988832 details
NCK1_HUMANRASA1_HUMANBioGRID, HPRD, IntAct10508618 21664272 9233798 details
NCK1_HUMANRL40_HUMANBioGRID, MINT21900206 details
NCK1_HUMANBLNK_HUMANBioGRID, HPRD, IntAct11487585 25241761 9697839 details
NCK1_HUMANGAB1_HUMANBioGRID, IntAct24728074 details
NCK1_HUMANKIT_HUMANBioGRID, IntAct24728074 details
NCK1_HUMANMET_HUMANBioGRID, IntAct24728074 details
NCK1_HUMANOLIG1_HUMANBioGRID, IntAct25814554 details
NCK1_HUMANP55G_HUMANBioGRID, IntAct25814554 details
NCK1_HUMANSH21A_HUMANBioGRID, IntAct25814554 details
NCK1_HUMANBCAP_HUMANBioGRID, IntAct32296183 details
NCK1_HUMANCHIO_HUMANBioGRID, IntAct32203420 32296183 details
NCK1_HUMANNHSL2_HUMANBioGRID, IntAct32296183 details
NCK1_HUMANSPN90_HUMANBioGRID, HPRD, IntAct11278500 14559906 28514442 details
NCK1_HUMANADA19_HUMANUniProt25825872 details
NCK1_HUMANKHDR1_HUMANBioGRID, HPRD, IntAct10805734 22745667 31413325 9010224 9362449 details
NCK1_HUMANMINK1_HUMANBioGRID, HPRD15469942 details
NCK1_HUMANERBB4_HUMANBioGRID16729043 22973453 details
NCK1_HUMANRHG32_HUMANBioGRID, HPRD12819203 details
NCK1_HUMANSOCS1_HUMANBioGRID, HPRD10022833 29991678 details
NCK1_HUMANPKN2_HUMANBioGRID, HPRD10026169 8910519 details
NCK1_HUMANM4K4_HUMANBioGRID, HPRD10805734 9135144 details
NCK1_HUMANPAXI_HUMANBioGRID, HPRD10330411 details
NCK1_HUMANCASL_HUMANBioGRID, HPRD10808124 8879209 details
NCK1_HUMANFAK1_HUMANBioGRID11950595 8879209 details
NCK1_HUMANTBK1_HUMANBioGRID, HPRD7706279 details
NCK1_HUMANPAK1_HUMANBioGRID, HPRD10026169 10330411 10372803 11157752 11278241 11557983 8824201 9851874 details
NCK1_HUMANSOCS7_HUMANBioGRID, HPRD9344857 details
NCK1_HUMANDRD4_HUMANBioGRID, HPRD9843378 details
NCK1_HUMANGAB2_HUMANBioGRID10391903 details
NCK1_HUMANBCAR1_HUMANBioGRID, HPRD12135674 22974441 details
NCK1_HUMANPROF1_HUMANBioGRID9694849 details
NCK1_HUMANCAV2_HUMANBioGRID, HPRD12091389 details
NCK1_HUMANDOK1_HUMANBioGRID, HPRD11551902 12087092 22974441 details
NCK1_HUMANFGFR1_HUMANBioGRID22974441 details
NCK1_HUMANSYNPO_HUMANBioGRID24287595 details
NCK1_HUMANIF2B_HUMANBioGRID, HPRD11959995 details
NCK1_HUMANABI2_HUMANBioGRID26871637 details
NCK1_HUMANVINEX_HUMANBioGRID26871637 details
NCK1_HUMANGMPPA_HUMANBioGRID26871637 details
NCK1_HUMANNTM2F_HUMANBioGRID26871637 details
NCK1_HUMANHOMEZ_HUMANBioGRID26871637 details
NCK1_HUMANFCHO1_HUMANBioGRID26871637 details
NCK1_HUMANTPT1L_HUMANBioGRID32296183 details
NCK1_HUMANERBB2_HUMANBioGRID22973453 details
NCK1_HUMANNTRK2_HUMANHPRD12074588 details
NCK1_HUMANNCKP1_HUMANHPRD11418237 8605018 details
NCK1_HUMANVGFR1_HUMANHPRD9600074 details
NCK1_HUMANFLT3_HUMANHPRD10409713 details
NCK1_HUMANRHOU_HUMANHPRD, MINT15556869 details
NCK1_HUMANDOK2_HUMANBioGRID, HPRD, MINT10428862 11689432 details
NCK1_HUMANNPHN_HUMANHPRD, IntAct16525419 16543952 details
NCK1_HUMANVGFR2_HUMANBioGRID, HPRD, MINT12214271 16966330 9405464 details
NCK1_HUMANFYN_HUMANMINT16966330 details
NCK1_HUMANCD3Z_HUMANMINT18320063 details
NCK1_HUMANTBA1A_HUMANBioGRID, MINT17868192 details
NCK1_HUMANPGFRB_HUMANBioGRID, HPRD, MINT10026169 1333047 7692233 9362449 details
NCK1_HUMANCBLB_HUMANHPRD, MINT16503409 25218436 details
NCK1_HUMANMCE1_HUMANDIP25137142 details
NCK1_HUMANADA10_HUMANUniProt25036101 details
NCK1_HUMANSTK38_HUMANBioGRID, IntAct31980649 details
NCK1_HUMANARHG7_HUMANBioGRID, HPRD, IntAct10330411 14559906 31980649 details
NCK1_HUMANDCC_HUMANBioGRID, HPRD12149262 details
NCK1_HUMANRGPS1_HUMANBioGRID10747847 details
NCK1_HUMANP85A_HUMANBioGRID11418612 details
NCK1_HUMANKSYK_HUMANBioGRID22267732 details
NCK1_HUMANSHIP1_HUMANBioGRID22267732 details
NCK1_HUMANUBS3B_HUMANBioGRID22267732 details
NCK1_HUMANGRB2_HUMANBioGRID22267732 details
NCK1_HUMANBIP_HUMANBioGRID15908432 details
NCK1_HUMANRPGF5_HUMANBioGRID8561895 details
NCK1_HUMANDAB1_HUMANBioGRID14517291 details
NCK1_HUMANPRPS2_HUMANBioGRID31980649 details
NCK1_HUMANEPHB2_HUMANHPRD9233798 details
NCK1_HUMANRAC1_HUMANHPRD10766742 details
NCK1_HUMANKC1G2_HUMANHPRD9006905 details
NCK1_HUMANWASF1_HUMANHPRD8605018 details
NCK1_HUMANEI2BB_HUMANHPRD11959995 details
NCK1_HUMANCYFP2_HUMANHPRD8605018 details
NCK1_HUMANBRK1_HUMANHPRD8605018 details
NCK1_HUMANDRD3_HUMANHPRD9843378 details
NCK1_HUMANPLCG1_HUMANHPRD9314836 details
NCK1_HUMANCRK_HUMANHPRD9837978 details
NCK1_HUMANPAK3_HUMANHPRD11278553 details
NCK1_HUMANFRS2_HUMANHPRD12154000 details