Entity Details

Primary name LBP_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP18428
EntryNameLBP_HUMAN
FullNameLipopolysaccharide-binding protein
TaxID9606
Evidenceevidence at protein level
Length481
SequenceStatuscomplete
DateCreated1990-11-01
DateModified2021-06-02

Ontological Relatives

GenesLBP

GO terms

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GOName
GO:0001530 lipopolysaccharide binding
GO:0002224 toll-like receptor signaling pathway
GO:0002232 leukocyte chemotaxis involved in inflammatory response
GO:0002281 macrophage activation involved in immune response
GO:0005102 signaling receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0006953 acute-phase response
GO:0006968 cellular defense response
GO:0008228 opsonization
GO:0009986 cell surface
GO:0015920 lipopolysaccharide transport
GO:0016020 membrane
GO:0019221 cytokine-mediated signaling pathway
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032490 detection of molecule of bacterial origin
GO:0032496 response to lipopolysaccharide
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032722 positive regulation of chemokine production
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0033036 macromolecule localization
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034145 positive regulation of toll-like receptor 4 signaling pathway
GO:0043032 positive regulation of macrophage activation
GO:0045087 innate immune response
GO:0045919 positive regulation of cytolysis
GO:0050829 defense response to Gram-negative bacterium
GO:0050830 defense response to Gram-positive bacterium
GO:0060265 positive regulation of respiratory burst involved in inflammatory response
GO:0070062 extracellular exosome
GO:0070891 lipoteichoic acid binding
GO:0071222 cellular response to lipopolysaccharide
GO:0071223 cellular response to lipoteichoic acid
GO:0071723 lipopeptide binding
GO:0090023 positive regulation of neutrophil chemotaxis

Subcellular Location

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Subcellular Location
Cytoplasmic granule membrane
Secreted

Domains

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DomainNameCategoryType
IPR001124 Lipid-binding serum glycoprotein, C-terminalDomainDomain
IPR017942 Lipid-binding serum glycoprotein, N-terminalDomainDomain
IPR017943 Bactericidal permeability-increasing protein, alpha/beta domain superfamilyFamilyHomologous superfamily
IPR017954 Lipid-binding serum glycoprotein, conserved siteSiteConserved site
IPR030180 Lipopolysaccharide-binding proteinFamilyFamily
IPR030675 Lipid binding protein BPI/LBPFamilyFamily
IPR032942 BPI/LBP/Plunc familyFamilyFamily

Diseases

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