Entity Details

Primary name EFNA1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP20827
EntryNameEFNA1_HUMAN
FullNameEphrin-A1
TaxID9606
Evidenceevidence at protein level
Length205
SequenceStatuscomplete
DateCreated1991-02-01
DateModified2021-06-02

Ontological Relatives

GenesEFNA1

GO terms

Show/Hide Table
GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001525 angiogenesis
GO:0001934 positive regulation of protein phosphorylation
GO:0003180 aortic valve morphogenesis
GO:0003183 mitral valve morphogenesis
GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation
GO:0005102 signaling receptor binding
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0007267 cell-cell signaling
GO:0007411 axon guidance
GO:0010719 negative regulation of epithelial to mesenchymal transition
GO:0014028 notochord formation
GO:0016477 cell migration
GO:0033628 regulation of cell adhesion mediated by integrin
GO:0034446 substrate adhesion-dependent cell spreading
GO:0043409 negative regulation of MAPK cascade
GO:0043410 positive regulation of MAPK cascade
GO:0043535 regulation of blood vessel endothelial cell migration
GO:0045765 regulation of angiogenesis
GO:0046658 anchored component of plasma membrane
GO:0046875 ephrin receptor binding
GO:0048013 ephrin receptor signaling pathway
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050770 regulation of axonogenesis
GO:0050821 protein stabilization
GO:0061002 negative regulation of dendritic spine morphogenesis
GO:0061098 positive regulation of protein tyrosine kinase activity
GO:0070244 negative regulation of thymocyte apoptotic process
GO:1902004 positive regulation of amyloid-beta formation
GO:1902961 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
GO:1903051 negative regulation of proteolysis involved in cellular protein catabolic process

Subcellular Location

Show/Hide Table
Subcellular Location
Cell membrane
Secreted

Domains

Show/Hide Table
DomainNameCategoryType
IPR001799 Ephrin receptor-binding domainDomainDomain
IPR008972 CupredoxinFamilyHomologous superfamily
IPR019765 Ephrin, conserved siteSiteConserved site
IPR031328 EphrinFamilyFamily
IPR034252 Ephrin-A ectodomainDomainDomain

Diseases

Show/Hide Table