Entity Details

Primary name COMT_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP21964
EntryNameCOMT_HUMAN
FullNameCatechol O-methyltransferase
TaxID9606
Evidenceevidence at protein level
Length271
SequenceStatuscomplete
DateCreated1991-08-01
DateModified2021-06-02

Ontological Relatives

GenesCOMT

GO terms

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GOName
GO:0000287 magnesium ion binding
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0008171 O-methyltransferase activity
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016206 catechol O-methyltransferase activity
GO:0030424 axon
GO:0030425 dendrite
GO:0032259 methylation
GO:0032502 developmental process
GO:0042135 neurotransmitter catabolic process
GO:0042417 dopamine metabolic process
GO:0042424 catecholamine catabolic process
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular exosome
GO:0102084 L-dopa O-methyltransferase activity
GO:0102938 orcinol O-methyltransferase activity

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm

Domains

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DomainNameCategoryType
IPR002935 Class I-like SAM-dependent O-methyltransferaseFamilyFamily
IPR017128 Catechol O-methyltransferase, eukaryoticFamilyFamily
IPR029063 S-adenosyl-L-methionine-dependent methyltransferaseFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00118 AdemetionineDrugbanksmall molecule
DB00252 PhenytoinDrugbanksmall molecule
DB00255 DiethylstilbestrolDrugbanksmall molecule
DB00286 Conjugated estrogensDrugbanksmall molecule
DB00323 TolcaponeDrugbanksmall molecule
DB00494 EntacaponeDrugbanksmall molecule
DB00668 EpinephrineDrugbanksmall molecule
DB00714 ApomorphineDrugbanksmall molecule
DB00783 EstradiolDrugbanksmall molecule
DB00841 DobutamineDrugbanksmall molecule
DB00968 MethyldopaDrugbanksmall molecule
DB00977 EthinylestradiolDrugbanksmall molecule
DB00988 DopamineDrugbanksmall molecule
DB01141 MicafunginDrugbanksmall molecule
DB01420 Testosterone propionateDrugbanksmall molecule
DB02105 3,5-DinitrocatecholDrugbanksmall molecule
DB02342 2-MethoxyestradiolDrugbanksmall molecule
DB03336 BIADrugbanksmall molecule
DB03907 N-[(E)-3-[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]prop-2-enyl]-2,3-dihydroxy-5-nitrobenzamideDrugbanksmall molecule
DB04820 NialamideDrugbanksmall molecule
DB06152 NylidrinDrugbanksmall molecule
DB07462 (3,4-DIHYDROXY-2-NITROPHENYL)(PHENYL)METHANONEDrugbanksmall molecule
DB08049 7,8-dihydroxy-4-phenyl-2H-chromen-2-oneDrugbanksmall molecule
DB11632 OpicaponeDrugbanksmall molecule
DB15488 EchinacosideDrugbanksmall molecule

Interactions

99 interactions

InteractorPartnerSourcesPublicationsLink
COMT_HUMANXRN2_HUMANBioGRID, HPRD, IntAct15231747 details
COMT_HUMANLITAF_HUMANHPRD, IntAct16169070 details
COMT_HUMANPCH2_HUMANBioGRID, HPRD, IntAct16189514 19060904 25416956 details
COMT_HUMANRGS2_HUMANBioGRID, MINT21900206 details
COMT_HUMANKRA59_HUMANBioGRID, IntAct25416956 details
COMT_HUMANCDC27_HUMANBioGRID, IntAct25416956 details
COMT_HUMANK1H1_HUMANBioGRID, IntAct25416956 details
COMT_HUMANK1C40_HUMANBioGRID, IntAct25416956 details
COMT_HUMANMTR1A_HUMANBioGRID, IntAct26514267 details
COMT_HUMANCR3L1_HUMANBioGRID, IntAct32296183 details
COMT_HUMANTLCD4_HUMANBioGRID, IntAct32296183 details
COMT_HUMANLAT2_HUMANBioGRID, IntAct32296183 details
COMT_HUMANTM50A_HUMANBioGRID, IntAct32296183 details
COMT_HUMANCXB5_HUMANBioGRID, IntAct32296183 details
COMT_HUMANCNR2_HUMANBioGRID, IntAct32296183 details
COMT_HUMANTM222_HUMANBioGRID, IntAct32296183 details
COMT_HUMANTM100_HUMANBioGRID, IntAct32296183 details
COMT_HUMANCC4L_HUMANBioGRID, IntAct32296183 details
COMT_HUMANGPR42_HUMANBioGRID, IntAct32296183 details
COMT_HUMANVAMP5_HUMANBioGRID, IntAct32296183 details
COMT_HUMANMOT2_HUMANBioGRID, IntAct32296183 details
COMT_HUMANS1PR3_HUMANBioGRID, IntAct32296183 details
COMT_HUMANPGAP2_HUMANBioGRID, IntAct32296183 details
COMT_HUMANOTOP3_HUMANBioGRID, IntAct32296183 details
COMT_HUMANVAMP3_HUMANBioGRID, IntAct32296183 details
COMT_HUMANSL7A1_HUMANBioGRID, IntAct32296183 details
COMT_HUMANCXB3_HUMANBioGRID, IntAct32296183 details
COMT_HUMANSMIM1_HUMANBioGRID, IntAct32296183 details
COMT_HUMANTM205_HUMANBioGRID, IntAct32296183 details
COMT_HUMANFFAR3_HUMANBioGRID, IntAct32296183 details
COMT_HUMANCXB4_HUMANBioGRID, IntAct32296183 details
COMT_HUMANS35A4_HUMANBioGRID, IntAct32296183 details
COMT_HUMAN3BHS7_HUMANBioGRID, IntAct32296183 details
COMT_HUMANMADL2_HUMANBioGRID, IntAct32296183 details
COMT_HUMANS39A1_HUMANBioGRID, IntAct32296183 details
COMT_HUMANBEST2_HUMANBioGRID, IntAct32296183 details
COMT_HUMANHRG1_HUMANBioGRID, IntAct32296183 details
COMT_HUMANGET1_HUMANBioGRID, IntAct32296183 details
COMT_HUMANRHBD2_HUMANBioGRID, IntAct32296183 details
COMT_HUMANF209A_HUMANBioGRID, IntAct32296183 details
COMT_HUMANV2R_HUMANBioGRID, IntAct32296183 details
COMT_HUMANT120B_HUMANBioGRID, IntAct32296183 details
COMT_HUMANPLPP6_HUMANBioGRID, IntAct32296183 details
COMT_HUMANRHBL1_HUMANBioGRID, IntAct32296183 details
COMT_HUMANEMD_HUMANBioGRID, IntAct32296183 details
COMT_HUMANTM14B_HUMANBioGRID, IntAct32296183 details
COMT_HUMANSOAT_HUMANBioGRID, IntAct32296183 details
COMT_HUMANTM14C_HUMANBioGRID, IntAct32296183 details
COMT_HUMANMF14B_HUMANBioGRID, IntAct32296183 details
COMT_HUMANREEP4_HUMANBioGRID, IntAct32296183 details
COMT_HUMANS39A2_HUMANBioGRID, IntAct32296183 details
COMT_HUMANS35F1_HUMANBioGRID, IntAct32296183 details
COMT_HUMANTHS7A_HUMANBioGRID, IntAct32296183 details
COMT_HUMANCXB1_HUMANBioGRID, IntAct32296183 details
COMT_HUMANGP152_HUMANBioGRID, IntAct32296183 details
COMT_HUMANTM187_HUMANBioGRID, IntAct32296183 details
COMT_HUMANGTR5_HUMANBioGRID, IntAct32296183 details
COMT_HUMANTRFR_HUMANBioGRID, IntAct32296183 details
COMT_HUMANSELK_HUMANBioGRID, IntAct32296183 details
COMT_HUMANKCNK5_HUMANBioGRID, IntAct32296183 details
COMT_HUMAN3HIDH_HUMANBioGRID, IntAct32296183 details
COMT_HUMANGP161_HUMANBioGRID, IntAct32296183 details
COMT_HUMANNIPA4_HUMANBioGRID, IntAct32296183 details
COMT_HUMANCREB3_HUMANIntAct31515488 details
COMT_HUMANRSPO1_HUMANIntAct32814053 details
COMT_HUMANWDR31_HUMANIntAct32814053 details
COMT_HUMANDCR1B_HUMANIntAct32814053 details
COMT_HUMANSYRM_HUMANIntAct32814053 details
COMT_HUMANUTP6_HUMANIntAct32814053 details
COMT_HUMANLSM1_HUMANIntAct32814053 details
COMT_HUMANRYBP_HUMANIntAct32814053 details
COMT_HUMANSEPT6_HUMANIntAct32814053 details
COMT_HUMANANM5_HUMANIntAct32814053 details
COMT_HUMANCHIP_HUMANIntAct32814053 details
COMT_HUMANRIMS3_HUMANIntAct32814053 details
COMT_HUMANSCO1_HUMANIntAct32814053 details
COMT_HUMANMPRD_HUMANIntAct32814053 details
COMT_HUMANEPHB2_HUMANIntAct32814053 details
COMT_HUMANDVL3_HUMANIntAct32814053 details
COMT_HUMANFGFR3_HUMANIntAct32814053 details
COMT_HUMANGELS_HUMANIntAct32814053 details
COMT_HUMANWFS1_HUMANIntAct32814053 details
COMT_HUMANVKOR1_HUMANBioGRID21103663 details
COMT_HUMANGLP1R_HUMANBioGRID28597972 details
COMT_HUMANCDC42_HUMANBioGRID31478661 31536960 details
COMT_HUMANAQP7_HUMANBioGRID32296183 details
COMT_HUMANS35U4_HUMANBioGRID32296183 details
COMT_HUMANCRCM_HUMANIntAct17353931 details
COMT_HUMANRAB14_HUMANBioGRID, IntAct27173435 unassigned1312 details
COMT_HUMANRAB2A_HUMANBioGRID, IntAct27173435 unassigned1312 details
COMT_HUMANCCHL_HUMANBioGRID, IntAct27173435 unassigned1312 details
COMT_HUMANGLCM_HUMANBioGRID, IntAct27173435 unassigned1312 details
COMT_HUMANNSDHL_HUMANBioGRID, IntAct27173435 unassigned1312 details
COMT_HUMANDCAKD_HUMANBioGRID, IntAct27173435 unassigned1312 details
COMT_HUMANRDH11_HUMANBioGRID, IntAct27173435 unassigned1312 details
COMT_HUMANESYT1_HUMANBioGRID, IntAct27173435 unassigned1312 details
COMT_HUMANTMX1_HUMANBioGRID, IntAct27173435 unassigned1312 details
COMT_HUMANFXR2_HUMANMINT21653829 details
COMT_HUMANACE_HUMANHPRD12729939 details