Entity Details

Primary name CAH4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP22748
EntryNameCAH4_HUMAN
FullNameCarbonic anhydrase 4
TaxID9606
Evidenceevidence at protein level
Length312
SequenceStatuscomplete
DateCreated1991-08-01
DateModified2021-06-02

Ontological Relatives

GenesCA4

GO terms

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GOName
GO:0004089 carbonate dehydratase activity
GO:0005791 rough endoplasmic reticulum
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0005886 plasma membrane
GO:0006730 one-carbon metabolic process
GO:0008270 zinc ion binding
GO:0009986 cell surface
GO:0015701 bicarbonate transport
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0016836 hydro-lyase activity
GO:0030658 transport vesicle membrane
GO:0030667 secretory granule membrane
GO:0031362 anchored component of external side of plasma membrane
GO:0031526 brush border membrane
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR001148 Alpha carbonic anhydrase domainDomainDomain
IPR018338 Carbonic anhydrase, alpha-class, conserved siteSiteConserved site
IPR018343 Carbonic anhydrase, CA4FamilyFamily
IPR023561 Carbonic anhydrase, alpha-classFamilyFamily
IPR036398 Alpha carbonic anhydrase domain superfamilyFamilyHomologous superfamily
IPR041874 Carbonic anhydrase, CA4/CA15FamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB00232 MethyclothiazideDrugbanksmall molecule
DB00273 TopiramateDrugbanksmall molecule
DB00311 EthoxzolamideDrugbanksmall molecule
DB00436 BendroflumethiazideDrugbanksmall molecule
DB00562 BenzthiazideDrugbanksmall molecule
DB00606 CyclothiazideDrugbanksmall molecule
DB00703 MethazolamideDrugbanksmall molecule
DB00774 HydroflumethiazideDrugbanksmall molecule
DB00819 AcetazolamideDrugbanksmall molecule
DB00869 DorzolamideDrugbanksmall molecule
DB00909 ZonisamideDrugbanksmall molecule
DB01021 TrichlormethiazideDrugbanksmall molecule
DB01144 DiclofenamideDrugbanksmall molecule
DB01194 BrinzolamideDrugbanksmall molecule
DB08846 Ellagic acidDrugbanksmall molecule
DB09460 Sodium carbonateDrugbanksmall molecule

Interactions

6 interactions