Entity Details

Primary name APC_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP25054
EntryNameAPC_HUMAN
FullNameAdenomatous polyposis coli protein
TaxID9606
Evidenceevidence at protein level
Length2843
SequenceStatuscomplete
DateCreated1992-05-01
DateModified2021-06-02

Ontological Relatives

GenesAPC

GO terms

Show/Hide Table
GOName
GO:0000281 mitotic cytokinesis
GO:0000776 kinetochore
GO:0001708 cell fate specification
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005874 microtubule
GO:0005886 plasma membrane
GO:0005912 adherens junction
GO:0005923 bicellular tight junction
GO:0006974 cellular response to DNA damage stimulus
GO:0007026 negative regulation of microtubule depolymerization
GO:0007094 mitotic spindle assembly checkpoint signaling
GO:0007155 cell adhesion
GO:0007389 pattern specification process
GO:0007399 nervous system development
GO:0008013 beta-catenin binding
GO:0008017 microtubule binding
GO:0008285 negative regulation of cell population proliferation
GO:0008286 insulin receptor signaling pathway
GO:0010942 positive regulation of cell death
GO:0016055 Wnt signaling pathway
GO:0016328 lateral plasma membrane
GO:0016342 catenin complex
GO:0016477 cell migration
GO:0016579 protein deubiquitination
GO:0019887 protein kinase regulator activity
GO:0019901 protein kinase binding
GO:0030027 lamellipodium
GO:0030335 positive regulation of cell migration
GO:0030877 beta-catenin destruction complex
GO:0031274 positive regulation of pseudopodium assembly
GO:0031625 ubiquitin protein ligase binding
GO:0032587 ruffle membrane
GO:0032886 regulation of microtubule-based process
GO:0043065 positive regulation of apoptotic process
GO:0045295 gamma-catenin binding
GO:0045595 regulation of cell differentiation
GO:0045732 positive regulation of protein catabolic process
GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0048471 perinuclear region of cytoplasm
GO:0051010 microtubule plus-end binding
GO:0051988 regulation of attachment of spindle microtubules to kinetochore
GO:0065003 protein-containing complex assembly
GO:0070830 bicellular tight junction assembly
GO:0070840 dynein complex binding
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0120162 positive regulation of cold-induced thermogenesis
GO:1904781 positive regulation of protein localization to centrosome
GO:1904885 beta-catenin destruction complex assembly
GO:1904886 beta-catenin destruction complex disassembly
GO:1990909 Wnt signalosome
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle

Subcellular Location

Show/Hide Table
Subcellular Location
Cell junction
Cell membrane
Cell projection
Cytoplasm

Domains

Show/Hide Table
DomainNameCategoryType
IPR000225 ArmadilloRepeatRepeat
IPR009223 Adenomatous polyposis coli protein repeatRepeatRepeat
IPR009224 SAMPRepeatRepeat
IPR009232 EB-1 bindingDomainDomain
IPR009234 Adenomatous polyposis coli protein basic domainDomainDomain
IPR009240 Adenomatous polyposis coli protein, 15 residue repeatRepeatRepeat
IPR011989 Armadillo-like helicalFamilyHomologous superfamily
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR026818 Adenomatous polyposis coli (APC) familyFamilyFamily
IPR026831 Adenomatous polyposis coli proteinFamilyHomologous superfamily
IPR026836 Adenomatous polyposis coliFamilyFamily
IPR032038 Adenomatous polyposis coli, N-terminal dimerisation domainDomainDomain
IPR036149 APC, N-terminal coiled-coil domain superfamilyFamilyHomologous superfamily
IPR041257 Adenomatous polyposis coli (APC) repeatRepeatRepeat

Diseases

Show/Hide Table

Interactions

182 interactions

InteractorPartnerSourcesPublicationsLink
APC_HUMANMARE1_HUMANBioGRID, HPRD, IntAct, MINT11470413 11943150 12388762 19632184 23001180 26496610 27698945 29162697 34079125 7606712 details
APC_HUMANCTNB1_HUMANbhf-ucl, BioGRID, DIP, HPRD, IntAct, MINT10545404 11166179 11251183 11533658 11707392 11712088 11972058 12000790 12628243 15327768 15327769 15355978 15525529 16212417 16510874 17318191 17510365 19576224 21664290 22056988 22682247 23840886 25241761 26496610 27684187 27902311 29045831 32533114 34079125 7890674 8259519 8638126 9286858 9482734 9707618 details
APC_HUMANKC1E_HUMANBioGRID, HPRD, IntAct11425858 11487578 15327768 17218255 25241761 29045831 details
APC_HUMANSCRIB_HUMANBioGRID, IntAct, MINT16611247 30126976 details
APC_HUMANAXIN1_HUMANbhf-ucl, BioGRID, HPRD, IntAct, MINT10228155 10811618 11297546 16199882 17510365 18786926 19131971 20128690 22682247 23277359 26496610 29045831 29713058 9734785 details
APC_HUMANDVLP1_HUMANMINT20224554 details
APC_HUMANANR17_HUMANBioGRID, IntAct20936779 details
APC_HUMANANXA7_HUMANBioGRID, IntAct20936779 details
APC_HUMANAP2B1_HUMANBioGRID, IntAct20936779 34079125 details
APC_HUMANACTN1_HUMANBioGRID, IntAct20936779 details
APC_HUMANCTNA1_HUMANBioGRID, IntAct20936779 25241761 26496610 29045831 34079125 7651399 8259519 details
APC_HUMANCGNL1_HUMANBioGRID, IntAct20936779 details
APC_HUMANCOG4_HUMANBioGRID, IntAct20936779 details
APC_HUMANCOG5_HUMANBioGRID, IntAct20936779 details
APC_HUMANCBP_HUMANBioGRID, IntAct20936779 details
APC_HUMANSMC3_HUMANBioGRID, IntAct20936779 details
APC_HUMANDYST_HUMANBioGRID, IntAct20936779 details
APC_HUMANGOGA2_HUMANBioGRID, IntAct20936779 details
APC_HUMANHGS_HUMANBioGRID, IntAct20936779 details
APC_HUMANAGFG1_HUMANBioGRID, IntAct20936779 details
APC_HUMANFLNA_HUMANBioGRID, IntAct20936779 details
APC_HUMANFHOD1_HUMANBioGRID, IntAct20936779 details
APC_HUMANEPAS1_HUMANBioGRID, IntAct20936779 details
APC_HUMANERBIN_HUMANBioGRID, IntAct15123239 20936779 details
APC_HUMANFBX30_HUMANBioGRID, IntAct20936779 details
APC_HUMANBIP_HUMANBioGRID, IntAct20936779 details
APC_HUMANK1C14_HUMANBioGRID, IntAct20936779 details
APC_HUMANK1C13_HUMANBioGRID, IntAct20936779 details
APC_HUMANKINH_HUMANBioGRID, IntAct20936779 details
APC_HUMANPLAK_HUMANBioGRID, HPRD, IntAct11136974 11348595 11707392 20936779 25241761 26496610 7651399 8074697 9298899 details
APC_HUMANING5_HUMANBioGRID, IntAct20936779 details
APC_HUMANK1C19_HUMANBioGRID, IntAct20936779 34079125 details
APC_HUMANK1C17_HUMANBioGRID, IntAct20936779 details
APC_HUMANAGRL1_HUMANBioGRID, IntAct20936779 details
APC_HUMANLAMA4_HUMANBioGRID, IntAct20936779 details
APC_HUMANLAMA3_HUMANBioGRID, IntAct20936779 details
APC_HUMANK1C15_HUMANBioGRID, IntAct20936779 details
APC_HUMANK2C5_HUMANBioGRID, IntAct20936779 details
APC_HUMANK1C23_HUMANBioGRID, IntAct20936779 details
APC_HUMANNAV3_HUMANBioGRID, IntAct20936779 details
APC_HUMANNAV2_HUMANBioGRID, IntAct20936779 details
APC_HUMANNAV1_HUMANBioGRID, IntAct20936779 details
APC_HUMANNCKP5_HUMANBioGRID, IntAct20936779 details
APC_HUMANMYH11_HUMANBioGRID, IntAct20936779 details
APC_HUMANMYH10_HUMANBioGRID, IntAct20936779 details
APC_HUMANMBD5_HUMANBioGRID, IntAct20936779 details
APC_HUMANMACF1_HUMANBioGRID, IntAct20936779 details
APC_HUMANGANP_HUMANBioGRID, IntAct20936779 details
APC_HUMANMYO6_HUMANBioGRID, IntAct20936779 details
APC_HUMANNU153_HUMANBioGRID, IntAct20936779 details
APC_HUMANNU214_HUMANBioGRID, IntAct20936779 details
APC_HUMANNUP54_HUMANBioGRID, IntAct20936779 details
APC_HUMANNUP98_HUMANBioGRID, IntAct20936779 details
APC_HUMANNUP58_HUMANBioGRID, IntAct20936779 details
APC_HUMANNUP42_HUMANBioGRID, IntAct20936779 details
APC_HUMANNEBU_HUMANBioGRID, IntAct20936779 details
APC_HUMANRANB9_HUMANBioGRID, IntAct20936779 details
APC_HUMANP121A_HUMANBioGRID, IntAct20936779 details
APC_HUMANASPP1_HUMANBioGRID, IntAct20936779 details
APC_HUMANCYH2_HUMANBioGRID, IntAct20936779 details
APC_HUMANPSMD1_HUMANBioGRID, IntAct20936779 details
APC_HUMANRBP2_HUMANBioGRID, IntAct19654215 20936779 29045831 details
APC_HUMANRBM4B_HUMANBioGRID, IntAct20936779 details
APC_HUMANSC31A_HUMANBioGRID, IntAct20936779 details
APC_HUMANRS27_HUMANBioGRID, IntAct20936779 details
APC_HUMANSETB1_HUMANBioGRID, IntAct20936779 details
APC_HUMANSYNE1_HUMANBioGRID, IntAct20936779 details
APC_HUMANSPTN2_HUMANBioGRID, IntAct20936779 details
APC_HUMANEXPH5_HUMANBioGRID, IntAct20936779 details
APC_HUMANSPTB2_HUMANBioGRID, IntAct20936779 details
APC_HUMANTAF1_HUMANBioGRID, IntAct20936779 details
APC_HUMANRO52_HUMANBioGRID, IntAct20936779 29045831 details
APC_HUMANTPR_HUMANBioGRID, IntAct20936779 details
APC_HUMANZN106_HUMANBioGRID, IntAct20936779 details
APC_HUMANNOSTN_HUMANBioGRID, IntAct20936779 details
APC_HUMANCYTSA_HUMANBioGRID, IntAct20936779 details
APC_HUMANPNISR_HUMANBioGRID, IntAct20936779 details
APC_HUMANK1328_HUMANBioGRID, IntAct20936779 details
APC_HUMANF214A_HUMANBioGRID, IntAct20936779 details
APC_HUMANNCK5L_HUMANBioGRID, IntAct20936779 details
APC_HUMANGGYF2_HUMANBioGRID, IntAct20936779 details
APC_HUMANCO4A_HUMANBioGRID, IntAct20936779 details
APC_HUMANASAP1_HUMANBioGRID, MINT18786926 20509626 details
APC_HUMANPTN13_HUMANHPRD, MINT10951583 17240990 details
APC_HUMANSIAH1_HUMANBioGRID, HPRD, IntAct11389840 25241761 details
APC_HUMANCSK21_HUMANBioGRID, IntAct11972058 25241761 details
APC_HUMANBUB1_HUMANBioGRID, HPRD, IntAct11283619 25241761 details
APC_HUMANAMER3_HUMANMINT24251807 details
APC_HUMANAN32B_HUMANBioGRID, MINT24412244 details
APC_HUMANBAAT_HUMANBioGRID, MINT24412244 details
APC_HUMANTSTD2_HUMANBioGRID, MINT24412244 details
APC_HUMANFANCC_HUMANBioGRID, MINT24412244 details
APC_HUMANCATL2_HUMANBioGRID, MINT24412244 details
APC_HUMANMP2K1_HUMANBioGRID, MINT24412244 details
APC_HUMANSIAS_HUMANBioGRID, MINT24412244 details
APC_HUMANF16P1_HUMANBioGRID, MINT24412244 details
APC_HUMANSMAD1_HUMANBioGRID, MINT24412244 details
APC_HUMANRASA1_HUMANBioGRID, MINT24412244 details
APC_HUMANCANB2_HUMANBioGRID, MINT24412244 details
APC_HUMANTEFF1_HUMANBioGRID, MINT24412244 details
APC_HUMANTGFB1_HUMANBioGRID, MINT24412244 details
APC_HUMANTMOD1_HUMANBioGRID, MINT24412244 details
APC_HUMANZN510_HUMANBioGRID, MINT24412244 details
APC_HUMANAGR3_HUMANBioGRID, MINT25640309 details
APC_HUMANCASC3_HUMANBioGRID, MINT25640309 details
APC_HUMANCCL5_HUMANBioGRID, MINT25640309 details
APC_HUMANCP17A_HUMANBioGRID, MINT25640309 details
APC_HUMANDIRA3_HUMANBioGRID, MINT25640309 details
APC_HUMANDKK3_HUMANBioGRID, MINT25640309 details
APC_HUMANHXC6_HUMANBioGRID, MINT25640309 details
APC_HUMANARY2_HUMANBioGRID, MINT25640309 details
APC_HUMANIL24_HUMANBioGRID, MINT25640309 details
APC_HUMANPDLI2_HUMANBioGRID, MINT25640309 details
APC_HUMANST14_HUMANBioGRID, MINT25640309 details
APC_HUMANTFF1_HUMANBioGRID, MINT25640309 details
APC_HUMANTRI25_HUMANBioGRID, MINT25640309 details
APC_HUMANCTBP1_HUMANBioGRID, HPRD, IntAct15525529 16510875 26186194 26496610 28514442 details
APC_HUMANFA20C_HUMANIntAct22582013 details
APC_HUMANSPT13_HUMANIntAct17145773 17599059 details
APC_HUMANCDC42_HUMANIntAct17145773 21311754 details
APC_HUMANARHG4_HUMANBioGRID, DIP, HPRD, IntAct10947987 17145773 22000517 details
APC_HUMANLRP8_HUMANDIP19116273 details
APC_HUMANEPCR_HUMANDIP19116273 details
APC_HUMANKHDR1_HUMANDIP, IntAct22000517 31413325 details
APC_HUMANRAC1_HUMANIntAct21311754 details
APC_HUMANDLG1_HUMANIntAct23185543 30126976 details
APC_HUMAN2A5A_HUMANBioGRID, HPRD10092233 11585828 details
APC_HUMANTBA4A_HUMANBioGRID, HPRD11166179 details
APC_HUMANXPO1_HUMANBioGRID12070164 details
APC_HUMANAPC_HUMANBioGRID, HPRD10926498 12070164 8389242 details
APC_HUMANAP2A_HUMANBioGRID, HPRD15331612 details
APC_HUMANMARE2_HUMANBioGRID11470413 7606712 details
APC_HUMANKIFA3_HUMANBioGRID, HPRD11912492 details
APC_HUMANDLG3_HUMANBioGRID9188857 details
APC_HUMANBUB1B_HUMANBioGRID11283619 details
APC_HUMANAXIN2_HUMANBioGRID, HPRD10966653 details
APC_HUMANKC1A_HUMANBioGRID19426738 details
APC_HUMANNU4M_HUMANBioGRID20936779 details
APC_HUMANHNRPM_HUMANBioGRID20936779 details
APC_HUMANU520_HUMANBioGRID20936779 details
APC_HUMANHTRA2_HUMANBioGRID16007220 details
APC_HUMAN1433T_HUMANBioGRID15161933 details
APC_HUMANASAP2_HUMANBioGRID18786926 details
APC_HUMANMKRN1_HUMANBioGRID29713058 details
APC_HUMAN1433Z_HUMANMINT15161933 details
APC_HUMAN1433S_HUMANBioGRID, MINT15778465 details
APC_HUMANFBW1A_HUMANBioGRID, IntAct10074433 10228155 19615732 25900982 28514442 29045831 details
APC_HUMANDVL2_HUMANBioGRID, IntAct, MINT20224554 26496610 details
APC_HUMANPAXI_HUMANBioGRID, MINT20224554 34079125 details
APC_HUMANDVL1_HUMANIntAct, MINT11425858 20224554 details
APC_HUMANP121C_HUMANIntAct20936779 details
APC_HUMANGSK3B_HUMANbhf-ucl, BioGRID, HPRD, IntAct11166179 11251183 21118991 23602568 29045831 29568061 8638126 details
APC_HUMANSTRN3_HUMANBioGRID, IntAct18502210 24255178 details
APC_HUMANAMER1_HUMANbhf-ucl, BioGRID, IntAct, MINT17510365 24251807 26496610 details
APC_HUMANAMER2_HUMANMINT24251807 details
APC_HUMANMUC1_HUMANBioGRID, HPRD15020226 details
APC_HUMANCSK2B_HUMANBioGRID11972058 details
APC_HUMANDLGP1_HUMANBioGRID, HPRD9286858 details
APC_HUMANMD2L1_HUMANBioGRID9637688 details
APC_HUMANBUB3_HUMANBioGRID11283619 details
APC_HUMANZRAN1_HUMANBioGRID18281465 details
APC_HUMANCSN5_HUMANBioGRID19576224 details
APC_HUMANPCNA_HUMANBioGRID21664290 details
APC_HUMANRFA2_HUMANBioGRID21664290 details
APC_HUMANSTRN_HUMANBioGRID18502210 details
APC_HUMANSTRN4_HUMANBioGRID18502210 details
APC_HUMANTNKS1_HUMANBioGRID23277359 details
APC_HUMANHECD1_HUMANBioGRID23277359 details
APC_HUMANRN146_HUMANBioGRID23277359 details
APC_HUMANUBR5_HUMANBioGRID18076571 details
APC_HUMANUBP7_HUMANBioGRID29045831 31519875 details
APC_HUMANSMU1_HUMANBioGRID29507117 details
APC_HUMANPRC1_HUMANBioGRID26941395 details
APC_HUMANPATL1_HUMANBioGRID29395067 details
APC_HUMANSMAG2_HUMANBioGRID29395067 details
APC_HUMANCEP85_HUMANBioGRID29395067 details
APC_HUMANCNOT9_HUMANBioGRID29395067 details
APC_HUMANMKRN2_HUMANBioGRID29395067 details
APC_HUMANKAPCA_HUMANHPRD11050185 11166179 details
APC_HUMANRP1_HUMANHPRD10188731 details
APC_HUMANIQGA1_HUMANHPRD15572129 details
APC_HUMANPP2AA_HUMANHPRD10698523 details