Entity Details

Primary name APEX1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP27695
EntryNameAPEX1_HUMAN
FullNameDNA-(apurinic or apyrimidinic site) endonuclease
TaxID9606
Evidenceevidence at protein level
Length318
SequenceStatuscomplete
DateCreated1992-08-01
DateModified2021-06-02

Ontological Relatives

GenesAPEX1

GO terms

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GOName
GO:0071320 cellular response to cAMP
GO:0031490 chromatin DNA binding
GO:0097698 telomere maintenance via base-excision repair
GO:0044877 protein-containing complex binding
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0070301 cellular response to hydrogen peroxide
GO:0004519 endonuclease activity
GO:0004523 RNA-DNA hybrid ribonuclease activity
GO:0006310 DNA recombination
GO:0000723 telomere maintenance
GO:0000781 chromosome, telomeric region
GO:0003691 double-stranded telomeric DNA binding
GO:0004528 phosphodiesterase I activity
GO:0005634 nucleus
GO:0004844 uracil DNA N-glycosylase activity
GO:0003714 transcription corepressor activity
GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0005783 endoplasmic reticulum
GO:0008081 phosphoric diester hydrolase activity
GO:0008311 double-stranded DNA 3'-5' exodeoxyribonuclease activity
GO:0071375 cellular response to peptide hormone stimulus
GO:0005730 nucleolus
GO:0006287 base-excision repair, gap-filling
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0048471 perinuclear region of cytoplasm
GO:0051059 NF-kappaB binding
GO:0042493 response to drug
GO:0043488 regulation of mRNA stability
GO:0046872 metal ion binding
GO:0005840 ribosome
GO:0016491 oxidoreductase activity
GO:0006284 base-excision repair
GO:0042981 regulation of apoptotic process
GO:0003684 damaged DNA binding
GO:0004520 endodeoxyribonuclease activity
GO:0008408 3'-5' exonuclease activity
GO:0016890 site-specific endodeoxyribonuclease activity, specific for altered base
GO:0005667 transcription regulator complex
GO:0008309 double-stranded DNA exodeoxyribonuclease activity
GO:0003713 transcription coactivator activity
GO:0005739 mitochondrion
GO:0045454 cell redox homeostasis
GO:0080111 DNA demethylation
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
GO:0006281 DNA repair
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0007568 aging
GO:0014912 negative regulation of smooth muscle cell migration
GO:0005654 nucleoplasm
GO:0006286 base-excision repair, base-free sugar-phosphate removal
GO:0016607 nuclear speck

Subcellular Location

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Subcellular Location
Cytoplasm
Endoplasmic reticulum
Mitochondrion
Nucleus
Nucleus speckle

Domains

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DomainNameCategoryType
IPR004808 AP endonuclease 1FamilyFamily
IPR005135 Endonuclease/exonuclease/phosphataseDomainDomain
IPR020847 AP endonuclease 1, binding siteSiteBinding site
IPR020848 AP endonuclease 1, conserved siteSiteConserved site
IPR036691 Endonuclease/exonuclease/phosphatase superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB04967 LucanthoneDrugbanksmall molecule

Interactions

77 interactions

InteractorPartnerSourcesPublicationsLink
APEX1_HUMANHS71B_HUMANHPRD, MINT10629618 11133992 20808282 details
APEX1_HUMANNUDT3_HUMANBioGRID, MINT21900206 details
APEX1_HUMANDPOLB_HUMANBioGRID, HPRD, UniProt17803946 28986522 9207062 details
APEX1_HUMANNF2L2_HUMANIntAct32911434 details
APEX1_HUMANSRPK2_HUMANBioGRID, IntAct23602568 details
APEX1_HUMANMUTYH_HUMANBioGRID, DIP, HPRD11092888 19820168 24209961 28986522 details
APEX1_HUMANPCNA_HUMANBioGRID, HPRD10559261 11601988 details
APEX1_HUMANHS71A_HUMANHPRD, MINT10629618 11133992 20808282 details
APEX1_HUMANHNRPL_HUMANBioGRID, HPRD11809897 28986522 details
APEX1_HUMANDCTN1_HUMANBioGRID, HPRD28986522 9361024 details
APEX1_HUMANSIR1_HUMANBioGRID, UniProt19934257 details
APEX1_HUMANTHIO_HUMANBioGRID, DIP, HPRD10585464 11118054 22863883 8736558 9108029 details
APEX1_HUMANUBC9_HUMANBioGRID, HPRD12110916 details
APEX1_HUMANA4_HUMANBioGRID21832049 28986522 details
APEX1_HUMANCDC42_HUMANBioGRID31478661 details
APEX1_HUMANEP300_HUMANBioGRID, HPRD, I2D, MINT14633989 19934257 20808282 20856196 30110629 details
APEX1_HUMANHIF1A_HUMANBioGRID, HPRD10594042 details
APEX1_HUMANTE2IP_HUMANbhf-ucl, BioGRID21044950 details
APEX1_HUMANTERF2_HUMANbhf-ucl, BioGRID21044950 details
APEX1_HUMANRPC4_HUMANBioGRID, IntAct20211142 details
APEX1_HUMANGRAK_HUMANBioGRID17008916 details
APEX1_HUMANGRAA_HUMANBioGRID, HPRD12524539 12555094 17008916 details
APEX1_HUMANMDM2_HUMANBioGRID19219073 28986522 details
APEX1_HUMANUBR3_HUMANBioGRID21933813 details
APEX1_HUMANXRCC1_HUMANBioGRID, HPRD, UniProt11707423 19934257 28986522 details
APEX1_HUMANMCL1_HUMANBioGRID20829524 details
APEX1_HUMANHMGA1_HUMANBioGRID, IntAct18850631 details
APEX1_HUMANXRCC5_HUMANBioGRID8621488 details
APEX1_HUMANFBX7_HUMANBioGRID27503909 details
APEX1_HUMANSRPK1_HUMANBioGRID, IntAct23602568 details
APEX1_HUMANTERF1_HUMANbhf-ucl, BioGRID21044950 details
APEX1_HUMANFEN1_HUMANBioGRID, HPRD11601988 details
APEX1_HUMANTCF21_HUMANBioGRID, IntAct20211142 details
APEX1_HUMANHMGA2_HUMANBioGRID18850631 details
APEX1_HUMANHXC13_HUMANBioGRID, IntAct20211142 details
APEX1_HUMANABCE1_HUMANBioGRID25659154 details
APEX1_HUMANXRCC6_HUMANBioGRID, HPRD30585729 34079125 8621488 details
APEX1_HUMANAN32C_HUMANHPRD12524539 details
APEX1_HUMANPABP1_HUMANBioGRID22863883 28986522 details
APEX1_HUMANRNC_HUMANBioGRID28986522 details
APEX1_HUMANCCNA1_HUMANIntAct17353931 details
APEX1_HUMANSTAT3_HUMANBioGRID15735682 details
APEX1_HUMANASCL2_HUMANBioGRID20856196 details
APEX1_HUMANHDAC2_HUMANBioGRID14633989 details
APEX1_HUMANNPM_HUMANBioGRID19188445 28986522 details
APEX1_HUMANPRDX6_HUMANBioGRID19188445 28986522 details
APEX1_HUMANHDAC1_HUMANBioGRID, HPRD14633989 28986522 details
APEX1_HUMANCRCM_HUMANIntAct17353931 details
APEX1_HUMANEIF1B_HUMANIntAct17353931 details
APEX1_HUMANARF6_HUMANIntAct17353931 details
APEX1_HUMANAN32A_HUMANBioGRID, HPRD12524539 details
APEX1_HUMANK2C8_HUMANBioGRID19188445 details
APEX1_HUMANAPEX1_HUMANHPRD9108029 details
APEX1_HUMANYBOX1_HUMANBioGRID, I2D20856196 28986522 details
APEX1_HUMANRNF4_HUMANBioGRID20696907 details
APEX1_HUMANIF6_HUMANIntAct17353931 details
APEX1_HUMANHNRPU_HUMANBioGRID28986522 details
APEX1_HUMANPAK2_HUMANIntAct17353931 details
APEX1_HUMANP53_HUMANBioGRID, HPRD15824742 9119221 details
APEX1_HUMANSET_HUMANBioGRID, HPRD12524539 12628186 details
APEX1_HUMANTRAF6_HUMANIntAct17353931 details
APEX1_HUMANTRAF2_HUMANBioGRID17599408 details
APEX1_HUMANMEP50_HUMANBioGRID19188445 details
APEX1_HUMANTRXR1_HUMANBioGRID15824742 22863883 details
APEX1_HUMANPRP19_HUMANBioGRID19188445 28986522 details
APEX1_HUMANNDKA_HUMANHPRD12524539 details
APEX1_HUMANGA45A_HUMANBioGRID23485469 details
APEX1_HUMANNUCL_HUMANBioGRID28986522 details
APEX1_HUMANSIR6_HUMANBioGRID26063178 details
APEX1_HUMANTCPA_HUMANBioGRID19188445 28986522 details
APEX1_HUMANRSSA_HUMANBioGRID19188445 details
APEX1_HUMANSFPQ_HUMANBioGRID22939629 28986522 details
APEX1_HUMANCSK21_HUMANHPRD10023679 details
APEX1_HUMANHMGB2_HUMANHPRD12524539 details
APEX1_HUMANHLAB_HUMANIntAct17353931 details
APEX1_HUMANHDAC3_HUMANBioGRID14633989 details
APEX1_HUMANPRKN_HUMANBioGRID27148961 details