Entity Details

Primary name PSB5_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP28074
EntryNamePSB5_HUMAN
FullNameProteasome subunit beta type-5
TaxID9606
Evidenceevidence at protein level
Length263
SequenceStatuscomplete
DateCreated1992-08-01
DateModified2021-06-02

Ontological Relatives

GenesPSMB5

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000209 protein polyubiquitination
GO:0000502 proteasome complex
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0004175 endopeptidase activity
GO:0004298 threonine-type endopeptidase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005839 proteasome core complex
GO:0006508 proteolysis
GO:0006521 regulation of cellular amino acid metabolic process
GO:0006979 response to oxidative stress
GO:0008233 peptidase activity
GO:0010499 proteasomal ubiquitin-independent protein catabolic process
GO:0010972 negative regulation of G2/M transition of mitotic cell cycle
GO:0016032 viral process
GO:0016579 protein deubiquitination
GO:0019774 proteasome core complex, beta-subunit complex
GO:0031145 anaphase-promoting complex-dependent catabolic process
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0036388 pre-replicative complex assembly
GO:0038061 NIK/NF-kappaB signaling
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043488 regulation of mRNA stability
GO:0043687 post-translational protein modification
GO:0050852 T cell receptor signaling pathway
GO:0055085 transmembrane transport
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070062 extracellular exosome
GO:0070498 interleukin-1-mediated signaling pathway
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1901990 regulation of mitotic cell cycle phase transition
GO:1902036 regulation of hematopoietic stem cell differentiation

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000243 Peptidase T1A, proteasome beta-subunitFamilyFamily
IPR001353 Proteasome, subunit alpha/betaFamilyFamily
IPR016050 Proteasome beta-type subunit, conserved siteSiteConserved site
IPR023333 Proteasome B-type subunitFamilyFamily
IPR029055 Nucleophile aminohydrolases, N-terminalFamilyHomologous superfamily
IPR037558 Proteasome subunit beta 5FamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB00188 BortezomibDrugbanksmall molecule
DB08515 (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDEDrugbanksmall molecule
DB08889 CarfilzomibDrugbanksmall molecule

Interactions

68 interactions

InteractorPartnerSourcesPublicationsLink
PSB5_HUMANLSM1_HUMANBioGRID, HPRD, IntAct15231747 32296183 details
PSB5_HUMANPSA2_HUMANBioGRID, HPRD, IntAct14733938 15887188 19193609 20980621 22863883 22939629 24121268 26344197 details
PSB5_HUMANPSB1_HUMANBioGRID, HPRD, IntAct, MINT14733938 17506986 17948026 22863883 22939629 26344197 28514442 details
PSB5_HUMANPSB2_HUMANBioGRID, IntAct14733938 17948026 22863883 22939629 26344197 28514442 details
PSB5_HUMANPSB3_HUMANBioGRID, HPRD, IntAct, MINT14733938 17948026 22863883 22939629 26344197 28292943 28514442 details
PSB5_HUMANPSA3_HUMANBioGRID, HPRD, IntAct14733938 17948026 22863883 22939629 26344197 details
PSB5_HUMANPSB7_HUMANBioGRID, HPRD, IntAct, MINT14733938 17948026 20723761 22863883 22939629 26186194 26344197 28514442 details
PSB5_HUMANPOMP_HUMANBioGRID, HPRD, IntAct, MINT14733938 15944226 17189198 17948026 20980621 details
PSB5_HUMANPSA1_HUMANBioGRID, DIP, HPRD, IntAct12376572 14733938 22863883 22939629 25599644 26186194 26344197 28514442 29636472 details
PSB5_HUMANPSA6_HUMANBioGRID, MINT17948026 22863883 22939629 26344197 details
PSB5_HUMANPSB4_HUMANBioGRID, IntAct, MINT17948026 22863883 22939629 26186194 26344197 28514442 details
PSB5_HUMANNEMO_HUMANBioGRID, IntAct32296183 details
PSB5_HUMANNTAQ1_HUMANBioGRID, IntAct32296183 details
PSB5_HUMANTCHP_HUMANBioGRID, IntAct32296183 details
PSB5_HUMANCC150_HUMANBioGRID, IntAct32296183 details
PSB5_HUMANBAG4_HUMANBioGRID, IntAct32296183 details
PSB5_HUMANDUS29_HUMANBioGRID, IntAct32296183 details
PSB5_HUMANCLP1_HUMANBioGRID, IntAct32296183 details
PSB5_HUMANPKHN1_HUMANMINT29433439 details
PSB5_HUMANUBE2C_HUMANBioGRID20007692 details
PSB5_HUMANPSB6_HUMANBioGRID11745344 17948026 22863883 22939629 26344197 details
PSB5_HUMANXRN1_HUMANBioGRID15231747 details
PSB5_HUMANPSMG3_HUMANBioGRID17189198 details
PSB5_HUMANAPRIO_HUMANBioGRID21301993 details
PSB5_HUMANPRIO_HUMANBioGRID21301993 details
PSB5_HUMANGAGE7_HUMANBioGRID32296183 details
PSB5_HUMANGG12F_HUMANBioGRID32296183 details
PSB5_HUMANGG12G_HUMANBioGRID32296183 details
PSB5_HUMANGG12I_HUMANBioGRID32296183 details
PSB5_HUMANGGE2D_HUMANBioGRID32296183 details
PSB5_HUMANABCB5_HUMANHPRD15488952 details
PSB5_HUMANTAP2_HUMANHPRD15488952 details
PSB5_HUMANTAP1_HUMANHPRD15488952 details
PSB5_HUMANTRAF6_HUMANBioGRID, HPRD, IntAct14743216 17353931 details
PSB5_HUMANPINX1_HUMANIntAct17353931 details
PSB5_HUMANTRM7_HUMANIntAct17353931 details
PSB5_HUMANLFG4_HUMANIntAct17353931 details
PSB5_HUMANVHL_HUMANIntAct17353931 details
PSB5_HUMANRIPK2_HUMANIntAct17353931 details
PSB5_HUMANEPB41_HUMANIntAct17353931 details
PSB5_HUMANPRS7_HUMANBioGRID, IntAct21628461 22901813 22939629 26344197 details
PSB5_HUMANPSB9_HUMANBioGRID, IntAct10816564 22939629 26186194 28514442 30833792 details
PSB5_HUMANPSMD4_HUMANBioGRID, DIP22939629 24121268 26344197 30479383 details
PSB5_HUMANPLK1_HUMANBioGRID, HPRD11205743 details
PSB5_HUMANTERF1_HUMANBioGRID20811636 details
PSB5_HUMANHDAC5_HUMANBioGRID21081666 details
PSB5_HUMANRD23A_HUMANBioGRID19013454 details
PSB5_HUMANPSA4_HUMANBioGRID22863883 22939629 26344197 9311996 details
PSB5_HUMANRND1_HUMANBioGRID20980621 details
PSB5_HUMANFKBP8_HUMANBioGRID17573772 details
PSB5_HUMANPRS6A_HUMANBioGRID21628461 22939629 26344197 details
PSB5_HUMANPRS6B_HUMANBioGRID21628461 22939629 26344197 details
PSB5_HUMANPRS4_HUMANBioGRID21628461 22939629 26344197 details
PSB5_HUMANPRS8_HUMANBioGRID21628461 22939629 26344197 details
PSB5_HUMANUBP7_HUMANBioGRID19193609 details
PSB5_HUMANELP1_HUMANBioGRID18303054 details
PSB5_HUMANHS90A_HUMANBioGRID16263121 details
PSB5_HUMANPSDE_HUMANBioGRID17323924 24743594 26344197 27428775 28821611 details
PSB5_HUMANTRI18_HUMANBioGRID26748699 details
PSB5_HUMANTRIM1_HUMANBioGRID26748699 details
PSB5_HUMANCEP85_HUMANBioGRID26472760 details
PSB5_HUMANFBX7_HUMANBioGRID27497298 27503909 details
PSB5_HUMANUBE3A_HUMANBioGRID22645313 29426014 30257870 details
PSB5_HUMANFGF11_HUMANBioGRID28027390 details
PSB5_HUMANERCC8_HUMANBioGRID29225035 details
PSB5_HUMANERPG3_HUMANBioGRID29225035 details
PSB5_HUMANERCC6_HUMANBioGRID29225035 details
PSB5_HUMANP85A_HUMANHPRD18711014 details