Entity Details

Primary name 5HT1D_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP28221
EntryName5HT1D_HUMAN
FullName5-hydroxytryptamine receptor 1D
TaxID9606
Evidenceevidence at protein level
Length377
SequenceStatuscomplete
DateCreated1992-12-01
DateModified2021-06-02

Ontological Relatives

GenesHTR1D

GO terms

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GOName
GO:0004993 G protein-coupled serotonin receptor activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway
GO:0007268 chemical synaptic transmission
GO:0014827 intestine smooth muscle contraction
GO:0030425 dendrite
GO:0030594 neurotransmitter receptor activity
GO:0040012 regulation of locomotion
GO:0042310 vasoconstriction
GO:0045202 synapse
GO:0050795 regulation of behavior
GO:0051378 serotonin binding

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR000505 5-Hydroxytryptamine 1D receptorFamilyFamily
IPR002231 5-hydroxytryptamine receptor familyFamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00216 EletriptanDrugbanksmall molecule
DB00246 ZiprasidoneDrugbanksmall molecule
DB00248 CabergolineDrugbanksmall molecule
DB00315 ZolmitriptanDrugbanksmall molecule
DB00320 DihydroergotamineDrugbanksmall molecule
DB00321 AmitriptylineDrugbanksmall molecule
DB00334 OlanzapineDrugbanksmall molecule
DB00363 ClozapineDrugbanksmall molecule
DB00408 LoxapineDrugbanksmall molecule
DB00574 FenfluramineDrugbanksmall molecule
DB00589 LisurideDrugbanksmall molecule
DB00669 SumatriptanDrugbanksmall molecule
DB00696 ErgotamineDrugbanksmall molecule
DB00714 ApomorphineDrugbanksmall molecule
DB00715 ParoxetineDrugbanksmall molecule
DB00726 TrimipramineDrugbanksmall molecule
DB00734 RisperidoneDrugbanksmall molecule
DB00918 AlmotriptanDrugbanksmall molecule
DB00952 NaratriptanDrugbanksmall molecule
DB00953 RizatriptanDrugbanksmall molecule
DB00998 FrovatriptanDrugbanksmall molecule
DB01049 Ergoloid mesylateDrugbanksmall molecule
DB01186 PergolideDrugbanksmall molecule
DB01200 BromocriptineDrugbanksmall molecule
DB01221 KetamineDrugbanksmall molecule
DB01224 QuetiapineDrugbanksmall molecule
DB01238 AripiprazoleDrugbanksmall molecule
DB01239 ChlorprothixeneDrugbanksmall molecule
DB01267 PaliperidoneDrugbanksmall molecule
DB01392 YohimbineDrugbanksmall molecule
DB04948 LofexidineDrugbanksmall molecule
DB06096 NXN-188Drugbanksmall molecule
DB06153 PizotifenDrugbanksmall molecule
DB09304 SetiptilineDrugbanksmall molecule
DB11273 DihydroergocornineDrugbanksmall molecule
DB12141 GilteritinibDrugbanksmall molecule
DB13025 TiaprideDrugbanksmall molecule
DB13345 DihydroergocristineDrugbanksmall molecule
DB14185 Aripiprazole lauroxilDrugbanksmall molecule

Interactions

4 interactions