Entity Details

Primary name EPHA3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP29320
EntryNameEPHA3_HUMAN
FullNameEphrin type-A receptor 3
TaxID9606
Evidenceevidence at protein level
Length983
SequenceStatuscomplete
DateCreated1992-12-01
DateModified2021-06-02

Ontological Relatives

GenesEPHA3

GO terms

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GOName
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005003 ephrin receptor activity
GO:0005004 GPI-linked ephrin receptor activity
GO:0005005 transmembrane-ephrin receptor activity
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0005654 nucleoplasm
GO:0005769 early endosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007155 cell adhesion
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0007411 axon guidance
GO:0010717 regulation of epithelial to mesenchymal transition
GO:0010976 positive regulation of neuron projection development
GO:0015629 actin cytoskeleton
GO:0016477 cell migration
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0031965 nuclear membrane
GO:0032956 regulation of actin cytoskeleton organization
GO:0033674 positive regulation of kinase activity
GO:0043005 neuron projection
GO:0043087 regulation of GTPase activity
GO:0043235 receptor complex
GO:0045806 negative regulation of endocytosis
GO:0048013 ephrin receptor signaling pathway
GO:0051893 regulation of focal adhesion assembly
GO:0070507 regulation of microtubule cytoskeleton organization
GO:0071300 cellular response to retinoic acid
GO:0097155 fasciculation of sensory neuron axon
GO:0097156 fasciculation of motor neuron axon
GO:1903078 positive regulation of protein localization to plasma membrane

Subcellular Location

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Subcellular Location
Cell membrane
Secreted

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001090 Ephrin receptor ligand binding domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001426 Tyrosine-protein kinase, receptor class V, conserved siteSiteConserved site
IPR001660 Sterile alpha motif domainDomainDomain
IPR003961 Fibronectin type IIIDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR008979 Galactose-binding-like domain superfamilyFamilyHomologous superfamily
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-likeDomainDomain
IPR013761 Sterile alpha motif/pointed domain superfamilyFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR016257 Ephrin receptor type-A /type-BFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR027936 Ephrin receptor, transmembrane domainDomainDomain
IPR034266 Ephrin type-A receptor 3, ligand binding domainDomainDomain
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule

Interactions

37 interactions

InteractorPartnerSourcesPublicationsLink
EPHA3_HUMANCDN2A_HUMANBioGRID, IntAct17955473 details
EPHA3_HUMANRUFY1_HUMANHPRD, MINT11877430 details
EPHA3_HUMANRBM18_HUMANBioGRID, IntAct21988832 details
EPHA3_HUMANEPHA7_HUMANBioGRID, IntAct22036564 28514442 details
EPHA3_HUMANSRPK1_HUMANBioGRID, IntAct23602568 details
EPHA3_HUMANEFNA5_HUMANBioGRID, DIP, HPRD19823572 9195962 9245480 9751130 details
EPHA3_HUMANCTDS2_HUMANBioGRID, MINT28065597 details
EPHA3_HUMANDUS18_HUMANBioGRID, MINT28065597 details
EPHA3_HUMANDUS21_HUMANBioGRID, MINT28065597 details
EPHA3_HUMANSTYX_HUMANBioGRID, MINT28065597 details
EPHA3_HUMANTPTE_HUMANBioGRID, MINT28065597 details
EPHA3_HUMANILKAP_HUMANBioGRID, MINT28065597 details
EPHA3_HUMANMTMRB_HUMANBioGRID, MINT28065597 details
EPHA3_HUMANP53_HUMANBioGRID, HPRD15355990 details
EPHA3_HUMANEFNB2_HUMANBioGRID, HPRD8559144 9195962 details
EPHA3_HUMANEFNA1_HUMANBioGRID, HPRD8070404 9195962 details
EPHA3_HUMANEFNB1_HUMANBioGRID9195962 details
EPHA3_HUMANEFNA3_HUMANBioGRID9195962 details
EPHA3_HUMANEFNA4_HUMANBioGRID9195962 details
EPHA3_HUMANSRC_HUMANBioGRID9632142 details
EPHA3_HUMANFYN_HUMANBioGRID9632142 details
EPHA3_HUMANABL1_HUMANBioGRID11494128 details
EPHA3_HUMANARF_HUMANBioGRID17955473 details
EPHA3_HUMANFBX7_HUMANBioGRID27503909 details
EPHA3_HUMANERBB2_HUMANBioGRID30898150 details
EPHA3_HUMANRUFY2_HUMANHPRD11877430 details
EPHA3_HUMANCALM2_HUMANDIP19823572 details
EPHA3_HUMANADA10_HUMANDIP, HPRD16239146 19823572 details
EPHA3_HUMANCRK_HUMANBioGRID, HPRD11870224 details
EPHA3_HUMANHS90A_HUMANBioGRID31577226 details
EPHA3_HUMANCLH1_HUMANBioGRID31577226 details
EPHA3_HUMANMYH9_HUMANBioGRID31577226 details
EPHA3_HUMANNCAM1_HUMANBioGRID29670169 details
EPHA3_HUMANEPHA3_HUMANHPRD11870224 details
EPHA3_HUMANEFNA2_HUMANHPRD9751130 details
EPHA3_HUMANPIM1_HUMANHPRD16186805 details
EPHA3_HUMANSTAT3_HUMANHPRD16186805 details