Entity Details

Primary name PHB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP35232
EntryNamePHB_HUMAN
FullNameProhibitin
TaxID9606
Evidenceevidence at protein level
Length272
SequenceStatuscomplete
DateCreated1994-02-01
DateModified2021-06-02

Ontological Relatives

GenesPHB

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001541 ovarian follicle development
GO:0001552 ovarian follicle atresia
GO:0001649 osteoblast differentiation
GO:0001850 complement component C3a binding
GO:0001851 complement component C3b binding
GO:0002639 positive regulation of immunoglobulin production
GO:0003714 transcription corepressor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005769 early endosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006355 regulation of transcription, DNA-templated
GO:0006851 mitochondrial calcium ion transmembrane transport
GO:0007005 mitochondrion organization
GO:0007165 signal transduction
GO:0007202 activation of phospholipase C activity
GO:0008022 protein C-terminus binding
GO:0008285 negative regulation of cell population proliferation
GO:0009986 cell surface
GO:0010628 positive regulation of gene expression
GO:0010942 positive regulation of cell death
GO:0010944 negative regulation of transcription by competitive promoter binding
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0016575 histone deacetylation
GO:0019899 enzyme binding
GO:0023035 CD40 signaling pathway
GO:0030061 mitochondrial crista
GO:0030308 negative regulation of cell growth
GO:0031100 animal organ regeneration
GO:0031315 extrinsic component of mitochondrial outer membrane
GO:0031871 proteinase activated receptor binding
GO:0032740 positive regulation of interleukin-17 production
GO:0035632 mitochondrial prohibitin complex
GO:0035902 response to immobilization stress
GO:0039529 RIG-I signaling pathway
GO:0042113 B cell activation
GO:0042177 negative regulation of protein catabolic process
GO:0042493 response to drug
GO:0042826 histone deacetylase binding
GO:0042981 regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043434 response to peptide hormone
GO:0044830 modulation by host of viral RNA genome replication
GO:0045471 response to ethanol
GO:0045745 positive regulation of G protein-coupled receptor signaling pathway
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045917 positive regulation of complement activation
GO:0046718 viral entry into host cell
GO:0046982 protein heterodimerization activity
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050821 protein stabilization
GO:0050847 progesterone receptor signaling pathway
GO:0051897 positive regulation of protein kinase B signaling
GO:0060766 negative regulation of androgen receptor signaling pathway
GO:0070062 extracellular exosome
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071354 cellular response to interleukin-6
GO:0071897 DNA biosynthetic process
GO:0072538 T-helper 17 type immune response
GO:0098891 extrinsic component of presynaptic active zone membrane
GO:0098978 glutamatergic synapse
GO:0098982 GABA-ergic synapse
GO:0140374 antiviral innate immune response
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1990051 activation of protein kinase C activity
GO:2000323 negative regulation of glucocorticoid receptor signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Mitochondrion inner membrane
Nucleus

Domains

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DomainNameCategoryType
IPR000163 ProhibitinFamilyFamily
IPR001107 Band 7 domainDomainDomain
IPR036013 Band 7/SPFH domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB15495 RocaglamideDrugbanksmall molecule
DB15496 DidesmethylrocaglamideDrugbanksmall molecule

Interactions

99 interactions

InteractorPartnerSourcesPublicationsLink
PHB_HUMANE2F1_HUMANBioGRID, HPRD10523633 12065415 14500729 14637159 15141164 details
PHB_HUMANHDAC1_HUMANBioGRID, HPRD12466959 14637159 16964284 17932104 27025967 details
PHB_HUMANRBL1_HUMANBioGRID, HPRD10376528 details
PHB_HUMANNP1L1_HUMANBioGRID, IntAct20195357 27025967 details
PHB_HUMANCASC3_HUMANBioGRID, MINT25640309 details
PHB_HUMANRAF1_HUMANBioGRID, HPRD, Molecular Connections10523633 16041367 24568222 27025967 details
PHB_HUMANMCM7_HUMANBioGRID19377303 27025967 details
PHB_HUMANANXA2_HUMANBioGRID, HPRD12628297 27025967 details
PHB_HUMANRB_HUMANBioGRID, HPRD, MINT10376528 10523633 16964284 24380853 details
PHB_HUMANESR1_HUMANBioGRID17932104 details
PHB_HUMANMLP3A_HUMANBioGRID28017329 details
PHB_HUMANP53_HUMANBioGRID, HPRD, IntAct, MINT14500729 16319068 20134482 24380853 details
PHB_HUMANSC22A_HUMANBioGRID, IntAct32296183 details
PHB_HUMANXIAP_HUMANBioGRID27025967 details
PHB_HUMANCCL5_HUMANBioGRID, MINT25640309 details
PHB_HUMANLONF3_HUMANBioGRID, IntAct20195357 details
PHB_HUMANCOX6C_HUMANBioGRID, IntAct20195357 31536960 details
PHB_HUMANBCAS3_HUMANBioGRID, MINT25640309 details
PHB_HUMANMCM5_HUMANBioGRID19377303 27025967 details
PHB_HUMANRBL2_HUMANBioGRID, HPRD10376528 details
PHB_HUMANPTEN_HUMANBioGRID31685992 details
PHB_HUMANST14_HUMANBioGRID, MINT25640309 details
PHB_HUMANMCM2_HUMANBioGRID19377303 details
PHB_HUMANSTOM_HUMANBioGRID, IntAct27173435 unassigned1312 details
PHB_HUMANSMCA4_HUMANBioGRID12065415 15141164 details
PHB_HUMANSKP2_HUMANBioGRID, MINT20134482 30555578 details
PHB_HUMANADA10_HUMANIntAct20195357 details
PHB_HUMANMYOD1_HUMANBioGRID20195544 details
PHB_HUMANSMG5_HUMANBioGRID19725029 details
PHB_HUMANPPIA_HUMANBioGRID25678563 27025967 details
PHB_HUMANPARL_HUMANBioGRID31177901 details
PHB_HUMANBPIB1_HUMANBioGRID30886235 details
PHB_HUMANHS90B_HUMANBioGRID, IntAct19725029 20195357 27025967 details
PHB_HUMANHDAC5_HUMANBioGRID, IntAct21081666 23752268 details
PHB_HUMANNPM_HUMANBioGRID19725029 27025967 details
PHB_HUMANT2FA_HUMANIntAct20195357 details
PHB_HUMANPGAM5_HUMANBioGRID31177901 details
PHB_HUMANSUMO4_HUMANHPRD16236267 details
PHB_HUMANACTB_HUMANBioGRID, IntAct15047060 19725029 27025967 31536960 details
PHB_HUMANCWC15_HUMANIntAct20195357 details
PHB_HUMANACTN1_HUMANBioGRID12628297 details
PHB_HUMANMGMT_HUMANBioGRID16226712 details
PHB_HUMANUBC_HUMANBioGRID, MINT16196087 20134482 details
PHB_HUMANAN32B_HUMANIntAct20195357 details
PHB_HUMANSIN3A_HUMANBioGRID, HPRD12466959 details
PHB_HUMANRL7_HUMANBioGRID19725029 27025967 details
PHB_HUMANSTML2_HUMANBioGRID26344197 27025967 30555578 details
PHB_HUMANXPO1_HUMANBioGRID, HPRD, IntAct16319068 27025967 details
PHB_HUMAN1433Z_HUMANBioGRID19725029 details
PHB_HUMANARMC7_HUMANBioGRID26472760 details
PHB_HUMANSGIP1_HUMANIntAct20195357 details
PHB_HUMANAIF1_HUMANMINT24380853 details
PHB_HUMANSMCA2_HUMANBioGRID, HPRD12065415 15141164 details
PHB_HUMANRS4X_HUMANBioGRID19725029 27025967 details
PHB_HUMANPHB2_HUMANBioGRID, IntAct, UniProt17932104 20959514 24981860 26344197 27025967 28017329 30021884 31177901 31536960 34079125 details
PHB_HUMANNCOR1_HUMANBioGRID, HPRD12466959 details
PHB_HUMANSPRTN_HUMANBioGRID23254330 details
PHB_HUMANRB6I2_HUMANIntAct20195357 details
PHB_HUMANANDR_HUMANBioGRID16964284 details
PHB_HUMANRING2_HUMANBioGRID17873902 24457600 details
PHB_HUMANIPO11_HUMANBioGRID19725029 details
PHB_HUMANPB1_HUMANIntAct20195357 details
PHB_HUMANVDAC2_HUMANBioGRID19725029 26344197 27025967 31536960 details
PHB_HUMANDHX36_HUMANBioGRID, IntAct20195357 27025967 details
PHB_HUMAN1433B_HUMANBioGRID, MINT19725029 details
PHB_HUMANCAZA1_HUMANBioGRID19725029 details
PHB_HUMANSEPR_HUMANBioGRID26209915 details
PHB_HUMANU2AF2_HUMANBioGRID26641092 27025967 details
PHB_HUMANCHD2_HUMANIntAct20195357 details
PHB_HUMANTNR19_HUMANMINT30337686 details
PHB_HUMANUSP9X_HUMANIntAct20195357 details
PHB_HUMANPLEC_HUMANBioGRID19725029 details
PHB_HUMANM3K10_HUMANHPRD9629920 details
PHB_HUMANSCN8A_HUMANIntAct20195357 details
PHB_HUMANSET_HUMANIntAct20195357 details
PHB_HUMANC1QBP_HUMANBioGRID22904065 27025967 32877691 details
PHB_HUMANKPCD_HUMANBioGRID19725029 details
PHB_HUMANRASK_HUMANBioGRID16041367 details
PHB_HUMANPHF3_HUMANIntAct20195357 details
PHB_HUMANDPP6_HUMANIntAct20195357 details
PHB_HUMANTF3C1_HUMANBioGRID19725029 27025967 details
PHB_HUMANPARP1_HUMANBioGRID24140708 27025967 34079125 details
PHB_HUMANTF65_HUMANIntAct14743216 details
PHB_HUMANPTMA_HUMANIntAct20195357 details
PHB_HUMANTCAL2_HUMANIntAct20195357 details
PHB_HUMANPBDC1_HUMANIntAct20195357 details
PHB_HUMANFOS_HUMANMINT24380853 details
PHB_HUMANADT2_HUMANBioGRID, MINT19725029 24983503 27025967 details
PHB_HUMANLMNA_HUMANBioGRID19725029 25948554 details
PHB_HUMANRO52_HUMANBioGRID30886235 details
PHB_HUMANDTNA_HUMANBioGRID20111909 details
PHB_HUMANITA4_HUMANBioGRID22623428 details
PHB_HUMANAKA11_HUMANIntAct20195357 details
PHB_HUMANMAP1B_HUMANBioGRID, IntAct20195357 27025967 details
PHB_HUMANFSIP1_HUMANIntAct20195357 details
PHB_HUMANS61A2_HUMANIntAct20195357 details
PHB_HUMANRAPH1_HUMANBioGRID19725029 details
PHB_HUMANDREB_HUMANBioGRID19725029 details
PHB_HUMANCO9A2_HUMANBioGRID19725029 details