Entity Details

Primary name RFC1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP35251
EntryNameRFC1_HUMAN
FullNameReplication factor C subunit 1
TaxID9606
Evidenceevidence at protein level
Length1148
SequenceStatuscomplete
DateCreated1994-02-01
DateModified2021-06-02

Ontological Relatives

GenesRFC1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0003677 DNA binding
GO:0003689 DNA clamp loader activity
GO:0003690 double-stranded DNA binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005663 DNA replication factor C complex
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0006261 DNA-dependent DNA replication
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006287 base-excision repair, gap-filling
GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion
GO:0006297 nucleotide-excision repair, DNA gap filling
GO:0007004 telomere maintenance via telomerase
GO:0008047 enzyme activator activity
GO:0019904 protein domain specific binding
GO:0019985 translesion synthesis
GO:0031391 Elg1 RFC-like complex
GO:0032201 telomere maintenance via semi-conservative replication
GO:0033683 nucleotide-excision repair, DNA incision
GO:0042276 error-prone translesion synthesis
GO:0042769 DNA damage response, detection of DNA damage
GO:0043565 sequence-specific DNA binding
GO:0045893 positive regulation of transcription, DNA-templated
GO:0061860 DNA clamp unloader activity
GO:0070062 extracellular exosome
GO:0070987 error-free translesion synthesis
GO:0090618 DNA clamp unloading

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001357 BRCT domainDomainDomain
IPR003593 AAA+ ATPase domainDomainDomain
IPR003959 ATPase, AAA-type, coreDomainDomain
IPR008921 DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminalFamilyHomologous superfamily
IPR012178 Replication factor C subunit 1FamilyFamily
IPR013725 DNA replication factor RFC1, C-terminalDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR036420 BRCT domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

42 interactions

InteractorPartnerSourcesPublicationsLink
RFC1_HUMANRFC4_HUMANBioGRID, IntAct18245774 22939629 26344197 28514442 9092549 9488738 details
RFC1_HUMANRFC3_HUMANBioGRID, HPRD, IntAct18245774 22939629 26344197 8692848 9488738 details
RFC1_HUMANCSK2B_HUMANBioGRID, MINT21900206 details
RFC1_HUMANPCNA_HUMANBioGRID, HPRD, IntAct10353443 12045192 12171929 12192049 12400013 15225546 22939629 24958773 26344197 26496610 30301766 8861969 8999859 9092549 9649448 details
RFC1_HUMANSSBP3_HUMANBioGRID, IntAct20211142 details
RFC1_HUMANZSCA1_HUMANBioGRID, IntAct20211142 details
RFC1_HUMANHDAC1_HUMANBioGRID, HPRD12045192 details
RFC1_HUMANBRD4_HUMANBioGRID, HPRD12192049 31239290 32416067 details
RFC1_HUMANTF65_HUMANBioGRID, HPRD12509469 details
RFC1_HUMANMYOC_HUMANBioGRID, HPRD16289162 details
RFC1_HUMAN1433T_HUMANBioGRID15161933 details
RFC1_HUMANUBC_HUMANBioGRID28190767 details
RFC1_HUMANRFC2_HUMANBioGRID, HPRD, IntAct, UniProt15655353 18245774 22939629 26344197 9488738 details
RFC1_HUMANSMC1A_HUMANBioGRID, HPRD, IntAct16438930 26344197 details
RFC1_HUMANMYC_HUMANBioGRID, IntAct17353931 29467282 details
RFC1_HUMANRFC5_HUMANBioGRID, IntAct18245774 22939629 26344197 28514442 9488738 details
RFC1_HUMANATM_HUMANBioGRID10783165 details
RFC1_HUMANBLM_HUMANBioGRID10783165 details
RFC1_HUMANBRCA1_HUMANBioGRID, HPRD10783165 25184681 details
RFC1_HUMANMLH1_HUMANBioGRID10783165 details
RFC1_HUMANMRE11_HUMANBioGRID10783165 details
RFC1_HUMANMSH2_HUMANBioGRID10783165 details
RFC1_HUMANMSH6_HUMANBioGRID10783165 details
RFC1_HUMANNBN_HUMANBioGRID10783165 details
RFC1_HUMANRAD50_HUMANBioGRID10783165 details
RFC1_HUMANP53_HUMANBioGRID12509469 details
RFC1_HUMANCDK4_HUMANBioGRID, HPRD10353443 details
RFC1_HUMANCCND1_HUMANBioGRID, HPRD10353443 21654808 details
RFC1_HUMANRB_HUMANBioGRID10353443 details
RFC1_HUMANXRCC5_HUMANBioGRID12393188 26344197 details
RFC1_HUMANRAD17_HUMANBioGRID12400013 18245774 details
RFC1_HUMANCTF18_HUMANBioGRID18245774 details
RFC1_HUMANPMS1_HUMANBioGRID17148452 details
RFC1_HUMANRFA1_HUMANBioGRID24332808 26474068 details
RFC1_HUMANSPRTN_HUMANBioGRID23254330 details
RFC1_HUMANATRX_HUMANBioGRID29937341 details
RFC1_HUMANTRI29_HUMANBioGRID26095369 details
RFC1_HUMANSOX2_HUMANBioGRID21280222 details
RFC1_HUMANRFC1_HUMANHPRD12192049 details
RFC1_HUMANCEBPA_HUMANHPRD12509469 details
RFC1_HUMANTCAL1_HUMANHPRD10353443 details
RFC1_HUMANCASP3_HUMANHPRD9235961 9351817 details