Entity Details

Primary name OPRM_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP35372
EntryNameOPRM_HUMAN
FullNameMu-type opioid receptor
TaxID9606
Evidenceevidence at protein level
Length400
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesOPRM1

GO terms

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GOName
GO:0001965 G-protein alpha-subunit binding
GO:0002438 acute inflammatory response to antigenic stimulus
GO:0004930 G protein-coupled receptor activity
GO:0004979 beta-endorphin receptor activity
GO:0005245 voltage-gated calcium channel activity
GO:0005768 endosome
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005925 focal adhesion
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007197 adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007218 neuropeptide signaling pathway
GO:0007600 sensory perception
GO:0008022 protein C-terminus binding
GO:0008285 negative regulation of cell population proliferation
GO:0009314 response to radiation
GO:0019221 cytokine-mediated signaling pathway
GO:0019233 sensory perception of pain
GO:0019904 protein domain specific binding
GO:0030424 axon
GO:0030425 dendrite
GO:0031005 filamin binding
GO:0031635 adenylate cyclase-inhibiting opioid receptor signaling pathway
GO:0031681 G-protein beta-subunit binding
GO:0032094 response to food
GO:0032100 positive regulation of appetite
GO:0032496 response to lipopolysaccharide
GO:0032590 dendrite membrane
GO:0032839 dendrite cytoplasm
GO:0038003 G protein-coupled opioid receptor signaling pathway
GO:0038047 morphine receptor activity
GO:0042060 wound healing
GO:0042220 response to cocaine
GO:0042277 peptide binding
GO:0042383 sarcolemma
GO:0042755 eating behavior
GO:0042923 neuropeptide binding
GO:0043005 neuron projection
GO:0043204 perikaryon
GO:0043950 positive regulation of cAMP-mediated signaling
GO:0043951 negative regulation of cAMP-mediated signaling
GO:0044849 estrous cycle
GO:0045019 negative regulation of nitric oxide biosynthetic process
GO:0045121 membrane raft
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0048149 behavioral response to ethanol
GO:0050769 positive regulation of neurogenesis
GO:0051481 negative regulation of cytosolic calcium ion concentration
GO:0051930 regulation of sensory perception of pain
GO:0060079 excitatory postsynaptic potential
GO:0061358 negative regulation of Wnt protein secretion
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070848 response to growth factor
GO:0080135 regulation of cellular response to stress
GO:0097444 spine apparatus
GO:0099055 integral component of postsynaptic membrane
GO:0099056 integral component of presynaptic membrane
GO:0106072 negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:2000310 regulation of NMDA receptor activity

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection
Cytoplasm
Endosome
Perikaryon

Domains

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DomainNameCategoryType
IPR000105 Mu opioid receptorFamilyFamily
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR001418 Opioid receptorFamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00193 TramadolDrugbanksmall molecule
DB00295 MorphineDrugbanksmall molecule
DB00318 CodeineDrugbanksmall molecule
DB00321 AmitriptylineDrugbanksmall molecule
DB00327 HydromorphoneDrugbanksmall molecule
DB00333 MethadoneDrugbanksmall molecule
DB00454 MeperidineDrugbanksmall molecule
DB00497 OxycodoneDrugbanksmall molecule
DB00504 LevallorphanDrugbanksmall molecule
DB00514 DextromethorphanDrugbanksmall molecule
DB00611 ButorphanolDrugbanksmall molecule
DB00647 DextropropoxypheneDrugbanksmall molecule
DB00652 PentazocineDrugbanksmall molecule
DB00704 NaltrexoneDrugbanksmall molecule
DB00708 SufentanilDrugbanksmall molecule
DB00802 AlfentanilDrugbanksmall molecule
DB00813 FentanylDrugbanksmall molecule
DB00836 LoperamideDrugbanksmall molecule
DB00844 NalbuphineDrugbanksmall molecule
DB00854 LevorphanolDrugbanksmall molecule
DB00899 RemifentanilDrugbanksmall molecule
DB00904 OndansetronDrugbanksmall molecule
DB00913 AnileridineDrugbanksmall molecule
DB00921 BuprenorphineDrugbanksmall molecule
DB00956 HydrocodoneDrugbanksmall molecule
DB01081 DiphenoxylateDrugbanksmall molecule
DB01183 NaloxoneDrugbanksmall molecule
DB01192 OxymorphoneDrugbanksmall molecule
DB01209 DezocineDrugbanksmall molecule
DB01221 KetamineDrugbanksmall molecule
DB01227 LevacetylmethadolDrugbanksmall molecule
DB01238 AripiprazoleDrugbanksmall molecule
DB01433 Methadyl acetateDrugbanksmall molecule
DB01439 3-MethylthiofentanylDrugbanksmall molecule
DB01444 DimethylthiambuteneDrugbanksmall molecule
DB01452 DiamorphineDrugbanksmall molecule
DB01466 EthylmorphineDrugbanksmall molecule
DB01497 EtorphineDrugbanksmall molecule
DB01535 CarfentanilDrugbanksmall molecule
DB01548 DiprenorphineDrugbanksmall molecule
DB01565 DihydromorphineDrugbanksmall molecule
DB01571 3-MethylfentanylDrugbanksmall molecule
DB05046 V1003Drugbanksmall molecule
DB05492 Epicept NP-1Drugbanksmall molecule
DB05509 LI-301Drugbanksmall molecule
DB06204 TapentadolDrugbanksmall molecule
DB06230 NalmefeneDrugbanksmall molecule
DB06274 AlvimopanDrugbanksmall molecule
DB06409 Morphine glucuronideDrugbanksmall molecule
DB06738 KetobemidoneDrugbanksmall molecule
DB06800 MethylnaltrexoneDrugbanksmall molecule
DB09049 NaloxegolDrugbanksmall molecule
DB09061 CannabidiolDrugbanksmall molecule
DB09089 TrimebutineDrugbanksmall molecule
DB09173 ButyrfentanylDrugbanksmall molecule
DB09209 PholcodineDrugbanksmall molecule
DB09272 EluxadolineDrugbanksmall molecule
DB09289 TianeptineDrugbanksmall molecule
DB11130 OpiumDrugbanksmall molecule
DB11186 PentoxyverineDrugbanksmall molecule
DB11691 NaldemedineDrugbanksmall molecule
DB12668 MetenkefalinDrugbanksmall molecule
DB14009 Medical CannabisDrugbankbiotech
DB14011 NabiximolsDrugbanksmall molecule
DB14146 LoxicodegolDrugbanksmall molecule
DB14881 OliceridineDrugbanksmall molecule

Interactions

86 interactions

InteractorPartnerSourcesPublicationsLink
OPRM_HUMANGASP1_HUMANBioGRID, HPRD, IntAct12142540 15086532 details
OPRM_HUMANFLNA_HUMANHPRD, UniProt14573758 details
OPRM_HUMANWLS_HUMANBioGRID, IntAct, MINT, UniProt20214800 23840749 28298427 31286866 details
OPRM_HUMANRANB9_HUMANBioGRID, IntAct, UniProt19788913 23840749 details
OPRM_HUMANDOK5_HUMANBioGRID, IntAct23840749 details
OPRM_HUMANZYX_HUMANBioGRID, IntAct23840749 details
OPRM_HUMANAUP1_HUMANBioGRID, IntAct23840749 details
OPRM_HUMANSIAH1_HUMANBioGRID, IntAct23840749 details
OPRM_HUMANDOK4_HUMANBioGRID, IntAct23840749 details
OPRM_HUMANCSN5_HUMANBioGRID, IntAct23840749 details
OPRM_HUMANSIAH2_HUMANBioGRID, IntAct23840749 details
OPRM_HUMANVAPA_HUMANBioGRID, IntAct, MINT23840749 28298427 details
OPRM_HUMANKCNF1_HUMANBioGRID, IntAct23840749 details
OPRM_HUMANCXA4_HUMANBioGRID, IntAct, MINT23840749 28298427 details
OPRM_HUMANT4S4_HUMANBioGRID, IntAct32296183 details
OPRM_HUMANIFM3_HUMANBioGRID, IntAct32296183 details
OPRM_HUMANCL12B_HUMANBioGRID, IntAct32296183 details
OPRM_HUMANZNT2_HUMANBioGRID, IntAct32296183 details
OPRM_HUMANTX264_HUMANBioGRID, IntAct32296183 details
OPRM_HUMANMLP3A_HUMANBioGRID, IntAct32296183 details
OPRM_HUMANRPRM_HUMANBioGRID, IntAct32296183 details
OPRM_HUMANMFF_HUMANBioGRID, IntAct32296183 details
OPRM_HUMANSG1D1_HUMANBioGRID, IntAct32296183 details
OPRM_HUMANVA0E1_HUMANBioGRID, IntAct32296183 details
OPRM_HUMANEMP3_HUMANBioGRID, IntAct32296183 details
OPRM_HUMANPMP22_HUMANBioGRID, IntAct32296183 details
OPRM_HUMANMAL_HUMANBioGRID, IntAct32296183 details
OPRM_HUMANCY561_HUMANBioGRID, IntAct32296183 details
OPRM_HUMANCLC7A_HUMANBioGRID, IntAct32296183 details
OPRM_HUMANCLD22_HUMANBioGRID, IntAct32296183 details
OPRM_HUMANLRC25_HUMANBioGRID, IntAct32296183 details
OPRM_HUMANECHP_HUMANBioGRID, IntAct32296183 details
OPRM_HUMANVATL_HUMANBioGRID, IntAct32296183 details
OPRM_HUMANCLD10_HUMANBioGRID, IntAct32296183 details
OPRM_HUMANC2C2L_HUMANBioGRID, IntAct32296183 details
OPRM_HUMANS41A1_HUMANBioGRID, IntAct32296183 details
OPRM_HUMANMALL_HUMANBioGRID, IntAct32296183 details
OPRM_HUMANCNIH1_HUMANBioGRID, IntAct32296183 details
OPRM_HUMANLAT_HUMANBioGRID, IntAct32296183 details
OPRM_HUMANS38A7_HUMANBioGRID, IntAct32296183 details
OPRM_HUMANEMP1_HUMANBioGRID, IntAct32296183 details
OPRM_HUMANCD302_HUMANBioGRID, IntAct32296183 details
OPRM_HUMANSC22A_HUMANBioGRID, IntAct32296183 details
OPRM_HUMANNSG1_HUMANBioGRID, IntAct32296183 details
OPRM_HUMANCTXN3_HUMANBioGRID, IntAct32296183 details
OPRM_HUMANAL5AP_HUMANBioGRID, IntAct32296183 details
OPRM_HUMANCLD8_HUMANBioGRID, IntAct32296183 details
OPRM_HUMANMLP3C_HUMANBioGRID, IntAct32296183 details
OPRM_HUMANSERP2_HUMANBioGRID, IntAct32296183 details
OPRM_HUMANCC167_HUMANBioGRID, IntAct32296183 details
OPRM_HUMANCLCN7_HUMANBioGRID, IntAct32296183 details
OPRM_HUMANTM236_HUMANBioGRID, IntAct32296183 details
OPRM_HUMANLPAR3_HUMANBioGRID, IntAct32296183 details
OPRM_HUMANSMAGP_HUMANBioGRID, IntAct32296183 details
OPRM_HUMANBI1_HUMANBioGRID, IntAct32296183 details
OPRM_HUMANPLD3_HUMANBioGRID, IntAct32296183 details
OPRM_HUMANNELFA_HUMANBioGRID, MINT28298427 details
OPRM_HUMANGRM1_HUMANBioGRID, MINT28298427 details
OPRM_HUMANH6ST1_HUMANBioGRID, MINT28298427 details
OPRM_HUMANS39AD_HUMANBioGRID, MINT28298427 details
OPRM_HUMANSL9A9_HUMANBioGRID, MINT28298427 details
OPRM_HUMANYIPF3_HUMANBioGRID, MINT28298427 details
OPRM_HUMANCPLX1_HUMANBioGRID, MINT28298427 details
OPRM_HUMANADDG_HUMANBioGRID, MINT28298427 details
OPRM_HUMANRTP4_HUMANBioGRID, MINT28298427 details
OPRM_HUMANCALM1_HUMANBioGRID, HPRD11457836 details
OPRM_HUMANCALM2_HUMANBioGRID, HPRD11457836 details
OPRM_HUMANCALM3_HUMANBioGRID, HPRD11457836 details
OPRM_HUMANUBC_HUMANBioGRID23314748 details
OPRM_HUMANDNJB4_HUMANBioGRID, HPRD16542645 details
OPRM_HUMANADA33_HUMANBioGRID32296183 details
OPRM_HUMANTARG1_HUMANBioGRID32296183 details
OPRM_HUMANOPRX_HUMANBioGRID15748148 details
OPRM_HUMANDRD2_HUMANBioGRID31416253 details
OPRM_HUMANPEPL_HUMANHPRD12810704 details
OPRM_HUMANTECT2_HUMANBioGRID, MINT28298427 details
OPRM_HUMANOPRD_HUMANBioGRID, HPRD11069979 21220103 details
OPRM_HUMANPLD2_HUMANBioGRID, HPRD12519790 details
OPRM_HUMANARF1_HUMANBioGRID12519790 details
OPRM_HUMANGNAO_HUMANBioGRID, HPRD8393523 details
OPRM_HUMANTNIP1_HUMANBioGRID29237725 details
OPRM_HUMANSGMR1_HUMANBioGRID20089882 details
OPRM_HUMANARBK2_HUMANHPRD11060299 details
OPRM_HUMANGNAI1_HUMANHPRD12068084 details
OPRM_HUMANGNA15_HUMANHPRD9572309 details
OPRM_HUMANGNAI2_HUMANHPRD12068084 details