Entity Details

Primary name DRD3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP35462
EntryNameDRD3_HUMAN
FullNameD(3) dopamine receptor
TaxID9606
Evidenceevidence at protein level
Length400
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesDRD3

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go
GO:0002031 G protein-coupled receptor internalization
GO:0004930 G protein-coupled receptor activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006874 cellular calcium ion homeostasis
GO:0006914 autophagy
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway
GO:0007194 negative regulation of adenylate cyclase activity
GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway
GO:0007611 learning or memory
GO:0007612 learning
GO:0007626 locomotory behavior
GO:0008284 positive regulation of cell population proliferation
GO:0008542 visual learning
GO:0014059 regulation of dopamine secretion
GO:0019904 protein domain specific binding
GO:0030139 endocytic vesicle
GO:0031748 D1 dopamine receptor binding
GO:0032416 negative regulation of sodium:proton antiporter activity
GO:0032467 positive regulation of cytokinesis
GO:0032922 circadian regulation of gene expression
GO:0034776 response to histamine
GO:0035176 social behavior
GO:0035483 gastric emptying
GO:0035815 positive regulation of renal sodium excretion
GO:0042220 response to cocaine
GO:0042417 dopamine metabolic process
GO:0042493 response to drug
GO:0042995 cell projection
GO:0043066 negative regulation of apoptotic process
GO:0043266 regulation of potassium ion transport
GO:0043278 response to morphine
GO:0045177 apical part of cell
GO:0045187 regulation of circadian sleep/wake cycle, sleep
GO:0045776 negative regulation of blood pressure
GO:0045840 positive regulation of mitotic nuclear division
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046717 acid secretion
GO:0048148 behavioral response to cocaine
GO:0048715 negative regulation of oligodendrocyte differentiation
GO:0050482 arachidonic acid secretion
GO:0050709 negative regulation of protein secretion
GO:0050883 musculoskeletal movement, spinal reflex action
GO:0051481 negative regulation of cytosolic calcium ion concentration
GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway
GO:0051584 regulation of dopamine uptake involved in synaptic transmission
GO:0051898 negative regulation of protein kinase B signaling
GO:0051967 negative regulation of synaptic transmission, glutamatergic
GO:0060134 prepulse inhibition
GO:0060158 phospholipase C-activating dopamine receptor signaling pathway
GO:0060161 positive regulation of dopamine receptor signaling pathway
GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway
GO:0090325 regulation of locomotion involved in locomotory behavior
GO:0098978 glutamatergic synapse
GO:0098982 GABA-ergic synapse
GO:0099061 integral component of postsynaptic density membrane
GO:0099149 regulation of postsynaptic neurotransmitter receptor internalization
GO:1901386 negative regulation of voltage-gated calcium channel activity

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR000929 Dopamine receptor familyFamilyFamily
IPR001620 Dopamine D3 receptorFamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00246 ZiprasidoneDrugbanksmall molecule
DB00248 CabergolineDrugbanksmall molecule
DB00268 RopiniroleDrugbanksmall molecule
DB00334 OlanzapineDrugbanksmall molecule
DB00363 ClozapineDrugbanksmall molecule
DB00391 SulpirideDrugbanksmall molecule
DB00408 LoxapineDrugbanksmall molecule
DB00409 RemoxiprideDrugbanksmall molecule
DB00413 PramipexoleDrugbanksmall molecule
DB00477 ChlorpromazineDrugbanksmall molecule
DB00490 BuspironeDrugbanksmall molecule
DB00502 HaloperidolDrugbanksmall molecule
DB00543 AmoxapineDrugbanksmall molecule
DB00589 LisurideDrugbanksmall molecule
DB00714 ApomorphineDrugbanksmall molecule
DB00988 DopamineDrugbanksmall molecule
DB01049 Ergoloid mesylateDrugbanksmall molecule
DB01100 PimozideDrugbanksmall molecule
DB01184 DomperidoneDrugbanksmall molecule
DB01186 PergolideDrugbanksmall molecule
DB01200 BromocriptineDrugbanksmall molecule
DB01224 QuetiapineDrugbanksmall molecule
DB01235 LevodopaDrugbanksmall molecule
DB01238 AripiprazoleDrugbanksmall molecule
DB01239 ChlorprothixeneDrugbanksmall molecule
DB01267 PaliperidoneDrugbanksmall molecule
DB01392 YohimbineDrugbanksmall molecule
DB01403 MethotrimeprazineDrugbanksmall molecule
DB04946 IloperidoneDrugbanksmall molecule
DB05271 RotigotineDrugbanksmall molecule
DB05766 ACP-104Drugbanksmall molecule
DB06016 CariprazineDrugbanksmall molecule
DB06148 MianserinDrugbanksmall molecule
DB06216 AsenapineDrugbanksmall molecule
DB06288 AmisulprideDrugbanksmall molecule
DB06454 SarizotanDrugbanksmall molecule
DB06477 SumaniroleDrugbanksmall molecule
DB09014 CaptodiameDrugbanksmall molecule
DB09207 AS-8112Drugbanksmall molecule
DB09223 BlonanserinDrugbanksmall molecule
DB09286 PipamperoneDrugbanksmall molecule
DB09289 TianeptineDrugbanksmall molecule
DB11274 Dihydro-alpha-ergocryptineDrugbanksmall molecule
DB11275 EpicriptineDrugbanksmall molecule
DB12061 PardoprunoxDrugbanksmall molecule
DB12478 PiribedilDrugbanksmall molecule
DB13025 TiaprideDrugbanksmall molecule
DB13345 DihydroergocristineDrugbanksmall molecule
DB14185 Aripiprazole lauroxilDrugbanksmall molecule