Entity Details

Primary name TIMP3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP35625
EntryNameTIMP3_HUMAN
FullNameMetalloproteinase inhibitor 3
TaxID9606
Evidenceevidence at protein level
Length211
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesTIMP3

GO terms

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GOName
GO:0002020 protease binding
GO:0002576 platelet degranulation
GO:0004857 enzyme inhibitor activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0007601 visual perception
GO:0008191 metalloendopeptidase inhibitor activity
GO:0009725 response to hormone
GO:0010033 response to organic substance
GO:0010951 negative regulation of endopeptidase activity
GO:0031012 extracellular matrix
GO:0031089 platelet dense granule lumen
GO:0034097 response to cytokine
GO:0046872 metal ion binding
GO:0051045 negative regulation of membrane protein ectodomain proteolysis
GO:0062023 collagen-containing extracellular matrix
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway
GO:1904684 negative regulation of metalloendopeptidase activity

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR001134 Netrin domainDomainDomain
IPR001820 Protease inhibitor I35 (TIMP)FamilyFamily
IPR008993 Tissue inhibitor of metalloproteinases-like, OB-foldFamilyHomologous superfamily
IPR015612 Metalloproteinase inhibitor 3FamilyFamily
IPR027465 Proteinase inhibitor I35b (TIMP), C-terminalFamilyHomologous superfamily
IPR030490 Tissue inhibitor of metalloproteinase, conserved siteSiteConserved site

Diseases

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Drugs

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DrugNameSourceType
DB05383 PimagedineDrugbanksmall molecule