Entity Details

Primary name ZEB1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP37275
EntryNameZEB1_HUMAN
FullNameZinc finger E-box-binding homeobox 1
TaxID9606
Evidenceevidence at protein level
Length1124
SequenceStatuscomplete
DateCreated1994-10-01
DateModified2021-06-02

Ontological Relatives

GenesZEB1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007399 nervous system development
GO:0008270 zinc ion binding
GO:0019221 cytokine-mediated signaling pathway
GO:0030154 cell differentiation
GO:0045602 negative regulation of endothelial cell differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0048856 anatomical structure development
GO:0070888 E-box binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001356 Homeobox domainDomainDomain
IPR008598 Drought induced 19 protein type, zinc-binding domainDomainDomain
IPR009057 Homeobox-like domain superfamilyFamilyHomologous superfamily
IPR013087 Zinc finger C2H2-typeDomainDomain
IPR036236 Zinc finger C2H2 superfamilyFamilyHomologous superfamily

Diseases

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Interactions

33 interactions

InteractorPartnerSourcesPublicationsLink
ZEB1_HUMANCTBP1_HUMANBioGRID, HPRD, IntAct, MINT10359772 10567582 17967884 25086746 26186194 28514442 details
ZEB1_HUMANKAT5_HUMANBioGRID, HPRD11275565 details
ZEB1_HUMANCTBP2_HUMANBioGRID, HPRD10359772 10567582 12714599 19754958 25086746 9724649 details
ZEB1_HUMANUBP51_HUMANBioGRID29119051 32296027 32468048 details
ZEB1_HUMANNC2A_HUMANBioGRID, HPRD9418848 details
ZEB1_HUMANCDK6_HUMANBioGRID, IntAct22094256 details
ZEB1_HUMANSMAD7_HUMANBioGRID20514018 details
ZEB1_HUMANUBP7_HUMANBioGRID25086746 29119051 details
ZEB1_HUMANEP300_HUMANBioGRID, HPRD12743039 22384255 details
ZEB1_HUMANATM_HUMANBioGRID25086746 details
ZEB1_HUMANSIR1_HUMANBioGRID22249256 25086746 25870236 details
ZEB1_HUMANVCIP1_HUMANBioGRID29119051 details
ZEB1_HUMANSMAD3_HUMANBioGRID, HPRD12743038 details
ZEB1_HUMANSMAD6_HUMANBioGRID20514018 details
ZEB1_HUMANCBP_HUMANBioGRID12743039 details
ZEB1_HUMANCHK1_HUMANBioGRID25086746 details
ZEB1_HUMANZMIZ1_HUMANBioGRID26522984 details
ZEB1_HUMANSMAD2_HUMANBioGRID, HPRD12743038 details
ZEB1_HUMANSMCA4_HUMANBioGRID20418909 details
ZEB1_HUMANCSN5_HUMANBioGRID28479251 details
ZEB1_HUMANMPP8_HUMANBioGRID25870236 details
ZEB1_HUMANUBP42_HUMANBioGRID29119051 details
ZEB1_HUMANSERPH_HUMANBioGRID17546044 details
ZEB1_HUMANSOX2_HUMANBioGRID21532573 details
ZEB1_HUMANUBP10_HUMANBioGRID29119051 details
ZEB1_HUMANUBP54_HUMANBioGRID29119051 details
ZEB1_HUMANUBP53_HUMANBioGRID29119051 details
ZEB1_HUMANSMAD1_HUMANBioGRID12743038 details
ZEB1_HUMANUCHL3_HUMANBioGRID29119051 details
ZEB1_HUMANUBP29_HUMANBioGRID29119051 details
ZEB1_HUMANUBP13_HUMANBioGRID29119051 details
ZEB1_HUMANPAN2_HUMANBioGRID29119051 details
ZEB1_HUMANUBP26_HUMANBioGRID29119051 details