Entity Details

Primary name S19A1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP41440
EntryNameS19A1_HUMAN
FullNameReduced folate transporter
TaxID9606
Evidenceevidence at protein level
Length591
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesSLC19A1

GO terms

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GOName
GO:0005542 folic acid binding
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007565 female pregnancy
GO:0008514 organic anion transmembrane transporter activity
GO:0008517 folic acid transmembrane transporter activity
GO:0008518 folate:anion antiporter activity
GO:0015350 methotrexate transmembrane transporter activity
GO:0015711 organic anion transport
GO:0015884 folic acid transport
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0031526 brush border membrane
GO:0046655 folic acid metabolic process
GO:0051958 methotrexate transport
GO:0055085 transmembrane transport
GO:0061507 cyclic-GMP-AMP binding
GO:0098838 folate transmembrane transport
GO:0140360 cyclic-GMP-AMP transmembrane transporter activity
GO:0140361 cyclic-GMP-AMP transmembrane import across plasma membrane
GO:0150104 transport across blood-brain barrier
GO:1904447 folate import across plasma membrane

Subcellular Location

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Subcellular Location
Apical cell membrane
Basolateral cell membrane
Cell membrane

Domains

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DomainNameCategoryType
IPR002666 Reduced folate carrierFamilyFamily
IPR028339 Reduced folate transporter SLC19A1FamilyFamily
IPR036259 MFS transporter superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00507 NitazoxanideDrugbanksmall molecule
DB00563 MethotrexateDrugbanksmall molecule
DB01157 TrimetrexateDrugbanksmall molecule
DB06813 PralatrexateDrugbanksmall molecule
DB11256 Levomefolic acidSwissprotsmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
S19A1_HUMANK1C26_HUMANBioGRID, IntAct32296183 details