Entity Details

Primary name LEPR_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP48357
EntryNameLEPR_HUMAN
FullNameLeptin receptor
TaxID9606
Evidenceevidence at protein level
Length1165
SequenceStatuscomplete
DateCreated1996-02-01
DateModified2021-06-02

Ontological Relatives

GenesLEPR

GO terms

Show/Hide Table
GOName
GO:0001525 angiogenesis
GO:0001934 positive regulation of protein phosphorylation
GO:0004888 transmembrane signaling receptor activity
GO:0004896 cytokine receptor activity
GO:0005576 extracellular region
GO:0005977 glycogen metabolic process
GO:0006112 energy reserve metabolic process
GO:0006909 phagocytosis
GO:0007166 cell surface receptor signaling pathway
GO:0007275 multicellular organism development
GO:0008203 cholesterol metabolic process
GO:0009897 external side of plasma membrane
GO:0010507 negative regulation of autophagy
GO:0014009 glial cell proliferation
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0017046 peptide hormone binding
GO:0019221 cytokine-mediated signaling pathway
GO:0019953 sexual reproduction
GO:0019955 cytokine binding
GO:0030217 T cell differentiation
GO:0033210 leptin-mediated signaling pathway
GO:0038021 leptin receptor activity
GO:0042593 glucose homeostasis
GO:0042802 identical protein binding
GO:0043235 receptor complex
GO:0044321 response to leptin
GO:0045721 negative regulation of gluconeogenesis
GO:0046850 regulation of bone remodeling
GO:0051049 regulation of transport
GO:0051346 negative regulation of hydrolase activity
GO:0060259 regulation of feeding behavior
GO:0097009 energy homeostasis
GO:0098868 bone growth
GO:0120162 positive regulation of cold-induced thermogenesis
GO:0150104 transport across blood-brain barrier

Subcellular Location

Show/Hide Table
Subcellular Location
Basolateral cell membrane
Cell membrane
Secreted

Domains

Show/Hide Table
DomainNameCategoryType
IPR003529 Long hematopoietin receptor, Gp130 family 2, conserved siteSiteConserved site
IPR003531 Short hematopoietin receptor, family 1, conserved siteSiteConserved site
IPR003961 Fibronectin type IIIDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR010457 Immunoglobulin C2-set-like, ligand-bindingDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR015752 Leptin receptorFamilyFamily
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily
IPR041182 Leptin receptor, immunoglobulin-like domainDomainDomain

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB05098 LeptinDrugbanksmall molecule
DB09046 MetreleptinDrugbankbiotech