Entity Details

Primary name SOX2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP48431
EntryNameSOX2_HUMAN
FullNameTranscription factor SOX-2
TaxID9606
Evidenceevidence at protein level
Length317
SequenceStatuscomplete
DateCreated1996-02-01
DateModified2021-06-02

Ontological Relatives

GenesSOX2

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001649 osteoblast differentiation
GO:0001654 eye development
GO:0001714 endodermal cell fate specification
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006325 chromatin organization
GO:0006355 regulation of transcription, DNA-templated
GO:0009611 response to wounding
GO:0009653 anatomical structure morphogenesis
GO:0010468 regulation of gene expression
GO:0019221 cytokine-mediated signaling pathway
GO:0021781 glial cell fate commitment
GO:0021983 pituitary gland development
GO:0021984 adenohypophysis development
GO:0022409 positive regulation of cell-cell adhesion
GO:0030154 cell differentiation
GO:0030900 forebrain development
GO:0035019 somatic stem cell population maintenance
GO:0035198 miRNA binding
GO:0042246 tissue regeneration
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043410 positive regulation of MAPK cascade
GO:0043565 sequence-specific DNA binding
GO:0045165 cell fate commitment
GO:0045597 positive regulation of cell differentiation
GO:0045665 negative regulation of neuron differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048839 inner ear development
GO:0050680 negative regulation of epithelial cell proliferation
GO:0070848 response to growth factor
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0097150 neuronal stem cell population maintenance

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR009071 High mobility group box domainDomainDomain
IPR022097 Transcription factor SOXFamilyFamily
IPR032643 Transcription factor SOX-2FamilyFamily
IPR036910 High mobility group box domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

229 interactions

InteractorPartnerSourcesPublicationsLink
SOX2_HUMANAKT1_HUMANBioGRID26498353 30894683 details
SOX2_HUMANXPO1_HUMANBioGRID19591226 details
SOX2_HUMANOTU7B_HUMANBioGRID30405104 details
SOX2_HUMANPO5F1_HUMANbhf-ucl, BioGRID, HPRD, IntAct, MINT12923055 19736317 20505756 23539445 25702638 26687479 30442713 details
SOX2_HUMANSUMO1_HUMANBioGRID, IntAct25416956 31515488 details
SOX2_HUMANCASP8_HUMANBioGRID, MINT25640309 details
SOX2_HUMANLMBL3_HUMANBioGRID30442713 details
SOX2_HUMANFZR1_HUMANBioGRID23972993 details
SOX2_HUMANUBR5_HUMANBioGRID, MINT23667531 30894683 details
SOX2_HUMANNOS1_HUMANBioGRID26607632 details
SOX2_HUMANCDX1_HUMANBioGRID15143193 details
SOX2_HUMANALX4_HUMANBioGRID, IntAct20211142 details
SOX2_HUMANMK03_HUMANBioGRID29556337 details
SOX2_HUMANCOP1_HUMANBioGRID30405104 details
SOX2_HUMANKPCI_HUMANIntAct24525231 details
SOX2_HUMANSETD7_HUMANBioGRID25042802 details
SOX2_HUMANSMRC1_HUMANBioGRID, IntAct21532573 23540691 28794006 details
SOX2_HUMANCHD7_HUMANBioGRID, MINT21532573 23667531 28794006 details
SOX2_HUMANDNJA2_HUMANBioGRID, MINT21532573 23667531 details
SOX2_HUMANNCOR1_HUMANBioGRID, MINT21532573 23667531 28794006 details
SOX2_HUMANP66A_HUMANBioGRID, MINT21532573 23667531 details
SOX2_HUMANRBBP7_HUMANBioGRID21532573 details
SOX2_HUMANBACH1_HUMANBioGRID30891497 details
SOX2_HUMANRBX1_HUMANBioGRID30405104 details
SOX2_HUMANPITX1_HUMANBioGRID30713093 details
SOX2_HUMANARF3_HUMANBioGRID21280222 details
SOX2_HUMANYBOX1_HUMANBioGRID21280222 details
SOX2_HUMANRL24_HUMANBioGRID21280222 details
SOX2_HUMANRL26_HUMANBioGRID21280222 details
SOX2_HUMANMYO1E_HUMANBioGRID21280222 details
SOX2_HUMANILF3_HUMANBioGRID21280222 details
SOX2_HUMANMYPT1_HUMANBioGRID21280222 details
SOX2_HUMANNEB2_HUMANBioGRID21280222 details
SOX2_HUMANXRCC5_HUMANBioGRID, MINT21280222 23667531 details
SOX2_HUMANSOX2_HUMANBioGRID, MINT23667531 30405104 details
SOX2_HUMANUSP9X_HUMANBioGRID, MINT23667531 31605775 details
SOX2_HUMANHDAC3_HUMANBioGRID, MINT21532573 23667531 details
SOX2_HUMANCTNB1_HUMANBioGRID, MINT23539445 23667531 details
SOX2_HUMANZN281_HUMANBioGRID18757296 28794006 details
SOX2_HUMANDCAF5_HUMANBioGRID30442713 details
SOX2_HUMANROA2_HUMANBioGRID21280222 details
SOX2_HUMANHNRPL_HUMANBioGRID21280222 details
SOX2_HUMANG3BP1_HUMANBioGRID21280222 details
SOX2_HUMANTMOD3_HUMANBioGRID21280222 details
SOX2_HUMANFLNA_HUMANBioGRID21280222 details
SOX2_HUMANARPC5_HUMANBioGRID21280222 details
SOX2_HUMANDESP_HUMANBioGRID21280222 details
SOX2_HUMANHS90A_HUMANBioGRID21280222 details
SOX2_HUMANHS90B_HUMANBioGRID21280222 details
SOX2_HUMANFUS_HUMANBioGRID21280222 details
SOX2_HUMANSTAU1_HUMANBioGRID21280222 details
SOX2_HUMANDDX1_HUMANBioGRID21280222 details
SOX2_HUMANCOPA_HUMANBioGRID21280222 details
SOX2_HUMANEF2_HUMANBioGRID21280222 details
SOX2_HUMANSYFA_HUMANBioGRID21280222 details
SOX2_HUMANLEG1_HUMANBioGRID21280222 details
SOX2_HUMANLIMA1_HUMANBioGRID21280222 details
SOX2_HUMANRAI14_HUMANBioGRID21280222 details
SOX2_HUMANCUX1_HUMANBioGRID, MINT21532573 23667531 28794006 details
SOX2_HUMANDOCK7_HUMANBioGRID21532573 details
SOX2_HUMANP20L1_HUMANBioGRID30089852 30442713 details
SOX2_HUMANRFC1_HUMANBioGRID21280222 details
SOX2_HUMANRS20_HUMANBioGRID21280222 details
SOX2_HUMANRS3A_HUMANBioGRID21280222 details
SOX2_HUMANMYL6B_HUMANBioGRID21280222 details
SOX2_HUMANSNF5_HUMANBioGRID, MINT21532573 23667531 details
SOX2_HUMANUBP7_HUMANBioGRID, MINT23667531 details
SOX2_HUMANCTBP2_HUMANBioGRID21532573 details
SOX2_HUMANASH2L_HUMANBioGRID30089852 details
SOX2_HUMANRS11_HUMANBioGRID21280222 details
SOX2_HUMANRS17_HUMANBioGRID21280222 details
SOX2_HUMANRS6_HUMANBioGRID21280222 details
SOX2_HUMANARP5L_HUMANBioGRID21280222 details
SOX2_HUMANCOF1_HUMANBioGRID21280222 details
SOX2_HUMANCEBPB_HUMANBioGRID21280222 details
SOX2_HUMANMATR3_HUMANBioGRID21280222 details
SOX2_HUMANPARP1_HUMANBioGRID21280222 details
SOX2_HUMANPAX6_HUMANBioGRID12710953 details
SOX2_HUMANDDX17_HUMANBioGRID21280222 details
SOX2_HUMANRL27_HUMANBioGRID21280222 details
SOX2_HUMANBCLF1_HUMANBioGRID21280222 details
SOX2_HUMANFLII_HUMANBioGRID21280222 details
SOX2_HUMANSAHH2_HUMANBioGRID, MINT21280222 23667531 details
SOX2_HUMANARI1A_HUMANBioGRID, MINT21532573 23667531 28794006 details
SOX2_HUMANMTA1_HUMANBioGRID, MINT21532573 23667531 details
SOX2_HUMANSMRC2_HUMANBioGRID21532573 details
SOX2_HUMANCASP_HUMANBioGRID21532573 23667531 28794006 details
SOX2_HUMANTEAD1_HUMANBioGRID21532573 details
SOX2_HUMANSMCA5_HUMANBioGRID21280222 21532573 details
SOX2_HUMANWDR5_HUMANBioGRID29383478 30089852 details
SOX2_HUMANXRCC6_HUMANBioGRID21280222 details
SOX2_HUMANKHDR1_HUMANBioGRID21280222 details
SOX2_HUMANXRCC1_HUMANBioGRID21280222 details
SOX2_HUMANMYO1C_HUMANBioGRID21280222 details
SOX2_HUMANARC1A_HUMANBioGRID21280222 details
SOX2_HUMANCAPR1_HUMANBioGRID21280222 details
SOX2_HUMANRBP56_HUMANBioGRID21280222 details
SOX2_HUMANKDM6B_HUMANDIP22801502 details
SOX2_HUMANSOX5_HUMANBioGRID21532573 details
SOX2_HUMANRS4X_HUMANBioGRID21280222 details
SOX2_HUMANCO6A1_HUMANBioGRID21280222 details
SOX2_HUMANGRP75_HUMANBioGRID21280222 details
SOX2_HUMANMYEF2_HUMANBioGRID, MINT21532573 23667531 details
SOX2_HUMANRBBP4_HUMANBioGRID, MINT21532573 23667531 details
SOX2_HUMANMSI2H_HUMANBioGRID, MINT23667531 details
SOX2_HUMANZEB1_HUMANBioGRID21532573 details
SOX2_HUMANNFIB_HUMANBioGRID21532573 28794006 details
SOX2_HUMANTWST1_HUMANBioGRID21532573 details
SOX2_HUMANHNRPK_HUMANBioGRID21280222 details
SOX2_HUMANNOP58_HUMANBioGRID21280222 details
SOX2_HUMANDDX5_HUMANBioGRID21280222 details
SOX2_HUMANRS13_HUMANBioGRID21280222 details
SOX2_HUMANARPC4_HUMANBioGRID21280222 details
SOX2_HUMANCAPZB_HUMANBioGRID21280222 details
SOX2_HUMANEFHD2_HUMANBioGRID21280222 details
SOX2_HUMANNAT10_HUMANBioGRID21280222 details
SOX2_HUMANCYTSA_HUMANBioGRID21280222 details
SOX2_HUMANSALL1_HUMANBioGRID21532573 details
SOX2_HUMANTBX2_HUMANBioGRID23674600 details
SOX2_HUMANRL27A_HUMANBioGRID21280222 details
SOX2_HUMANRS12_HUMANBioGRID21280222 details
SOX2_HUMANLAP2A_HUMANBioGRID21280222 details
SOX2_HUMANACTBL_HUMANBioGRID21280222 details
SOX2_HUMANCHD4_HUMANBioGRID21532573 details
SOX2_HUMANCTBP1_HUMANBioGRID21532573 details
SOX2_HUMANDMAP1_HUMANBioGRID23884650 details
SOX2_HUMANKMT2A_HUMANBioGRID30089852 details
SOX2_HUMANLAMP2_HUMANBioGRID29556337 details
SOX2_HUMANARP3_HUMANBioGRID21280222 details
SOX2_HUMANPABP4_HUMANBioGRID21280222 details
SOX2_HUMANMBD3_HUMANBioGRID, DIP21532573 24048479 details
SOX2_HUMANHDAC1_HUMANBioGRID21532573 30442713 details
SOX2_HUMANACL6A_HUMANBioGRID21532573 details
SOX2_HUMANTFE2_HUMANBioGRID21532573 29383478 details
SOX2_HUMANZNF24_HUMANBioGRID21532573 details
SOX2_HUMANNUCL_HUMANBioGRID21280222 details
SOX2_HUMANEWS_HUMANBioGRID21280222 details
SOX2_HUMANRL18A_HUMANBioGRID21280222 details
SOX2_HUMANRS15A_HUMANBioGRID21280222 details
SOX2_HUMANRL18_HUMANBioGRID21280222 details
SOX2_HUMANADT2_HUMANBioGRID21280222 details
SOX2_HUMANCO6A3_HUMANBioGRID21280222 details
SOX2_HUMANATX2L_HUMANBioGRID21280222 details
SOX2_HUMANTCPG_HUMANBioGRID21280222 details
SOX2_HUMANCD59_HUMANBioGRID21280222 details
SOX2_HUMANCCAR2_HUMANBioGRID, MINT21532573 23667531 details
SOX2_HUMANNCOR2_HUMANBioGRID21532573 28794006 details
SOX2_HUMANTBL1R_HUMANBioGRID21532573 details
SOX2_HUMANSQSTM_HUMANBioGRID29556337 31823521 details
SOX2_HUMANRBM14_HUMANBioGRID21280222 details
SOX2_HUMANTR150_HUMANBioGRID21280222 details
SOX2_HUMANKDM6A_HUMANBioGRID, DIP22801502 28794006 details
SOX2_HUMANHDAC2_HUMANBioGRID21532573 details
SOX2_HUMANSIN3A_HUMANBioGRID21532573 details
SOX2_HUMANRUVB1_HUMANBioGRID21532573 details
SOX2_HUMANRFX3_HUMANBioGRID21532573 details
SOX2_HUMANCUL4A_HUMANBioGRID30405104 30442713 details
SOX2_HUMANHNRPC_HUMANBioGRID21280222 details
SOX2_HUMANARF4_HUMANBioGRID21280222 details
SOX2_HUMANRL11_HUMANBioGRID21280222 details
SOX2_HUMANG3BP2_HUMANBioGRID21280222 details
SOX2_HUMANANXA2_HUMANBioGRID21280222 details
SOX2_HUMAN5NTD_HUMANBioGRID21280222 details
SOX2_HUMANPRDX1_HUMANBioGRID21280222 details
SOX2_HUMANVRK1_HUMANIntAct27334688 details
SOX2_HUMANSALL3_HUMANBioGRID21532573 details
SOX2_HUMANHNRPM_HUMANBioGRID21280222 details
SOX2_HUMANNHP2_HUMANBioGRID21280222 details
SOX2_HUMANDHX30_HUMANBioGRID21280222 details
SOX2_HUMANRL4_HUMANBioGRID21280222 details
SOX2_HUMANRS14_HUMANBioGRID21280222 details
SOX2_HUMANKIF23_HUMANBioGRID21280222 details
SOX2_HUMANLACTB_HUMANBioGRID21280222 details
SOX2_HUMANSSRP1_HUMANBioGRID21280222 details
SOX2_HUMANNUFP2_HUMANBioGRID21280222 details
SOX2_HUMANRL8_HUMANBioGRID21280222 details
SOX2_HUMANEGFR_HUMANBioGRID31823521 details
SOX2_HUMANP66B_HUMANBioGRID21532573 details
SOX2_HUMANSP16H_HUMANBioGRID21280222 21532573 details
SOX2_HUMANRD23B_HUMANBioGRID21962512 details
SOX2_HUMANARI1B_HUMANBioGRID28794006 details
SOX2_HUMANDDB1_HUMANBioGRID30405104 30442713 details
SOX2_HUMANPTBP1_HUMANBioGRID21280222 details
SOX2_HUMANDDX3X_HUMANBioGRID21280222 details
SOX2_HUMANRL3_HUMANBioGRID21280222 details
SOX2_HUMANRL35A_HUMANBioGRID21280222 details
SOX2_HUMANGNAI2_HUMANBioGRID21280222 details
SOX2_HUMANLAP2B_HUMANBioGRID21280222 details
SOX2_HUMANACTN4_HUMANBioGRID21280222 details
SOX2_HUMANILF2_HUMANBioGRID21280222 details
SOX2_HUMANRUVB2_HUMANBioGRID21532573 details
SOX2_HUMANHXA5_HUMANBioGRID21532573 details
SOX2_HUMANROA3_HUMANBioGRID21280222 details
SOX2_HUMANHNRPR_HUMANBioGRID21280222 details
SOX2_HUMANDDX41_HUMANBioGRID21280222 details
SOX2_HUMANSSBP_HUMANBioGRID21280222 details
SOX2_HUMANRL34_HUMANBioGRID21280222 details
SOX2_HUMANRS19_HUMANBioGRID21280222 details
SOX2_HUMANFA98A_HUMANBioGRID21280222 details
SOX2_HUMANMAP1B_HUMANBioGRID21280222 details
SOX2_HUMANSALL2_HUMANBioGRID, IntAct21532573 24726434 details
SOX2_HUMANIF4A1_HUMANBioGRID21280222 details
SOX2_HUMANSTF1_HUMANHPRD12732652 details
SOX2_HUMANEP300_HUMANBioGRID28794006 details
SOX2_HUMANPO2F1_HUMANBioGRID, HPRD14559893 28794006 details
SOX2_HUMANHNRPU_HUMANBioGRID21280222 details
SOX2_HUMANDHX15_HUMANBioGRID21280222 details
SOX2_HUMANRL30_HUMANBioGRID21280222 details
SOX2_HUMANRS3_HUMANBioGRID21280222 details
SOX2_HUMANMYO1B_HUMANBioGRID21280222 details
SOX2_HUMANARPC2_HUMANBioGRID21280222 details
SOX2_HUMANH2AY_HUMANBioGRID21280222 details
SOX2_HUMANIF2B2_HUMANBioGRID21280222 details
SOX2_HUMANRS16_HUMANBioGRID21280222 details
SOX2_HUMANCAZA1_HUMANBioGRID21280222 details
SOX2_HUMANMECP2_HUMANBioGRID20368621 details
SOX2_HUMANRBBP5_HUMANBioGRID30089852 details
SOX2_HUMANCH60_HUMANBioGRID21280222 details
SOX2_HUMANLUZP1_HUMANBioGRID21280222 details
SOX2_HUMANSMRD1_HUMANBioGRID21532573 details
SOX2_HUMANNPM_HUMANBioGRID21280222 details
SOX2_HUMANRL12_HUMANBioGRID21280222 details
SOX2_HUMANSLTM_HUMANBioGRID21280222 details
SOX2_HUMANMTA2_HUMANBioGRID21532573 details
SOX2_HUMANSOX8_HUMANBioGRID21532573 details
SOX2_HUMANDET1_HUMANBioGRID30405104 details
SOX2_HUMANDHX9_HUMANBioGRID21280222 details
SOX2_HUMANSRC8_HUMANBioGRID21280222 details
SOX2_HUMANF120A_HUMANBioGRID21280222 details