Entity Details

Primary name IOD1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP49895
EntryNameIOD1_HUMAN
FullNameType I iodothyronine deiodinase
TaxID9606
Evidenceevidence at transcript level
Length249
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesDIO1

GO terms

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GOName
GO:0004800 thyroxine 5'-deiodinase activity
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0006520 cellular amino acid metabolic process
GO:0006590 thyroid hormone generation
GO:0008430 selenium binding
GO:0016021 integral component of membrane
GO:0042403 thyroid hormone metabolic process
GO:0042446 hormone biosynthetic process

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane

Domains

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DomainNameCategoryType
IPR000643 Iodothyronine deiodinaseFamilyFamily
IPR008261 Iodothyronine deiodinase, active siteSiteActive site
IPR027252 Iodothyronine deiodinase I/IIIFamilyFamily
IPR036249 Thioredoxin-like superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB09100 Thyroid, porcineDrugbankbiotech

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
IOD1_HUMANIOD1_HUMANHPRD12586771 details