Entity Details

Primary name DUS3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP51452
EntryNameDUS3_HUMAN
FullNameDual specificity protein phosphatase 3
TaxID9606
Evidenceevidence at protein level
Length185
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesDUSP3

GO terms

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GOName
GO:0000188 obsolete inactivation of MAPK activity
GO:0001772 immunological synapse
GO:0004725 protein tyrosine phosphatase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0008092 cytoskeletal protein binding
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0016311 dephosphorylation
GO:0016791 phosphatase activity
GO:0019901 protein kinase binding
GO:0030336 negative regulation of cell migration
GO:0030971 receptor tyrosine kinase binding
GO:0033549 MAP kinase phosphatase activity
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0043409 negative regulation of MAPK cascade
GO:0045931 positive regulation of mitotic cell cycle
GO:0046329 negative regulation of JNK cascade
GO:0050860 negative regulation of T cell receptor signaling pathway
GO:0050868 negative regulation of T cell activation
GO:0050922 negative regulation of chemotaxis
GO:0051893 regulation of focal adhesion assembly
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0106306 protein serine phosphatase activity
GO:0106307 protein threonine phosphatase activity
GO:0120183 positive regulation of focal adhesion disassembly
GO:1990264 peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
GO:1990782 protein tyrosine kinase binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000387 Tyrosine specific protein phosphatases domainDomainDomain
IPR016130 Protein-tyrosine phosphatase, active siteSiteActive site
IPR020405 Atypical dual specificity phosphatase, subfamily AFamilyFamily
IPR020422 Dual specificity protein phosphatase domainDomainDomain
IPR029021 Protein-tyrosine phosphatase-likeFamilyHomologous superfamily

Diseases

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